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If you choose to follow any links to the abstract and/or complete text of the item listed below, you will be leaving the Strategian Web site. If you wish to return to this page from the Web page you are sent to, please use the Back option of your browser. Stanley Fahn Description of Parkinson's Disease as a Clinical Syndrome. (... an important review of the pathology [the nature, causes, and development], biochemistry, clinical features and epidemiology [prevalence], physiology, treatment options, etc. of Parkinson's Disease. The author also provides an interesting account of the history of the description of and research into Parkinson's Disease and a discussion of Parkinsonism and other related syndromes. The author notes that parkinsonism is a clinical syndrome comprising combinations of motor [movement] problems--namely bradykinesia [extreme slowness in movement], resting tremor, rigidity, flexed [stooped] posture, freezing, and loss of postural reflexes. Parkinson's disease [PD] is the major cause of parkinsonism. The loss of dopamine [DA] content in the nigrostriatal neurons [in the brain] accounts for many of the motor symptoms, which can be ameliorated [made better] by DA replacement therapy--that is, levodopa. The author goes on to say that most cases of Parkinson's Disease are sporadic and of unknown etiology [unknown cause]. Nonmotor synptoms [such as depression, lack of motivation, passivity, and dementia] are common among people who have Parkinson's Disease. The origin and development of PD remains unknown. As the disease progresses, even motor symptoms become intractable [unmanageable by] to therapy. No proven means of slowing progression [of the disease] have yet been found. See table 2 for a classification of the parkinsonian states, figure 2 for a diagram of a typical clinical course of Parkinson's disease despite therapy, and table 4 for the nonmotor features of Parkinson's disease. Other keywords and phrases -- lewy bodies, lewy body -- from the text of the abstract; see the bibliography) Annals of the New York Academy of Sciences Volume 991 (2003): 1-14. **The complete text of the abstract is currently available through the Web site of Annals of the New York Academy of Sciences** How to find the above journal, magazine, or other publication? See Step 3: Locate of the Information Strategy for details. Questions? Please let me know. |
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