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If you choose to follow any links to the abstract and/or complete text of the item listed below, you will be leaving the Strategian Web site. If you wish to return to this page from the Web page you are sent to, please use the Back option of your browser. Eric Kübler, Bruno Oesch and Alex J Raeber Diagnosis of Prion Diseases. (... a review of the classical diagnostic methods as well as present and future tools for the diagnosis of prion diseases. Diseases caused by prions such as BSE or bovine spongiform encephalopathy [commonly called mad cow disease] in cattle are usually diagnosed clinically and confirmed after the animal has died by examination of brain tissue. The only reliable molecular marker for prion diseases is PrPSc, the pathological conformer of the prion protein that accumulates in the central nervous system and, to a lesser extent, in lymphoreticular tissues. For BSE, several commercial diagnostic kits based on the post-mortem ... detection of PrPSc in brain tissue are now available. These rapid screening tests have been used in active surveillance of BSE and have greatly improved the detection of infected cattle before their entry into the human food chain. At present, no diagnostic test exists for the detection of prion diseases in live animals or humans though new tests are under development. Other keywords and phrases -- CJD, Creutzfeldt-Jakob Disease, transmissible spongiform encephalopathies, TSE -- from the text of the abstract) British Medical Bulletin Volume 66 (2003): pages 267-279. **The complete text of the abstract is currently available through the Web site of the British Medical Bulletin** How to find the above journal, magazine, or other publication? See Step 3: Locate of the Information Strategy for details. Questions? Please let me know. |
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