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If you choose to follow any links to the complete text of articles listed below, you will be leaving the Strategian Web site. If you wish to return to this page from the Web page you are sent to, please use the Back option of your browser. Peter Harper The End in Sight? Some Speculations on Environmental Trends in the Twenty-first Century. (... a very interesting article that attempts to explain the paradox between the groups and individuals that have predicted--since the 1960's--environmental doom for the Earth, and those groups and individuals who have held very optimistic views of the Earth's environmental future. A paradox has been created, because each group has been able to show over the years considerable evidence that supports their respective positions. The author creates a model which looks at and predicts envirionmental trends from the 1950's through the year 2100. This model separates the world-wide environmental impact of the currently more-developed countries [North] from those countires that are currently less-developed [South]. From his model, the author concludes that the North's environmental impact will decline steadily, but in the South a rapid increase in environmental impact can be expected in the first half of the 21st century, followed by an equally rapid decline. This dramatic environmental `spike' will be unique in human history and mark a fundament transition to the sustainable state. Its qualities and duration will determine many features of the human and natural world for millennia to come. The author sees this damaging increase in environmental impact from the "South" in the near term as a necessary step to reaching a more sustainable world at the end of this century ... the spike should be managed and not avoided--from the text of the article; please see the bibliography of the article) Futures Volume 32, Numbers 3-4 (April 2000): 361-384. Marc E. Lippman Editorial: High-Dose Chemotherapy plus Autologous Bone Marrow Transplantation for Metastatic Breast Cancer. (... an editorial that considers a specific study [see immediately below] testing the effects of high-dose chemotherapy plus autologous bone marrow transplantation [hematopoietic stem-cell rescue] versus conventional-dose chemotherapy for women with breast cancer. The author then reviews the results of several similar studies in the recent past. The use of these more aggressive measures to treat breast cancer has many proponents and claims of very positive benefits for this treatment regimen have been drawn from a series of uncontrolled trials. After a review of this and other controlled clinical trials, the author concludes we should now acknowledge that, to a reasonable degree of probability, this form of treatment [high-dose chemotherapy] for women with metastatic breast cancer has been proved to be ineffective and should be abandoned in favor of well-justified alternative experimental approaches--from the text of the article) New England Journal of Medicine (Web release date: March 3, 2000 ... to be published in the April 13, 2000 issue) **The complete text of this article is currently available through the Web site of the New England Journal of Medicine** Edward A. Stadtmauer, Anne O'Neill, Lori J. Goldstein, Pamela A. Crilley, Kenneth F. Mangan, James N. Ingle, Isadore Brodsky, Silvana Martino, Hillard M. Lazarus, John K. Erban, Cheryl Sickles, John H. Glick, Selina M. Luger, Thomas R. Klumpp, Mark R. Litzow, and the Philadelphia Bone Marrow Transplant Group Conventional-Dose Chemotherapy Compared with High-Dose Chemotherapy plus Autologous Hematopoietic Stem-Cell Transplantation for Metastatic Breast Cancer. (... a study that compared--among 199 women with metastatic breast cancer among a total of 553 who enrolled in the study--survival rates for individuals receiving high-dose chemotherapy plus hematopoietic stem-cell rescue to treat the cancer with survival rates for individuals receiving a prolonged course of monthly conventional-dose chemotherapy to treat the cancer. From the results of the study, the authors conclude as compared with maintenance chemotherapy in conventional doses, high-dose chemotherapy plus autologous stem-cell transplantation soon after the induction of a complete or partial remission with conventional-dose chemotherapy does not improve survival in women with metastatic breast cancer--from the abstract of the article) New England Journal of Medicine (Web release date: March 3, 2000 ... to be published in the April 13, 2000 issue) **The complete text of this article is currently available through the Web site of the New England Journal of Medicine** How to find the above journals, magazines, and other publications? See Step 3: Locate of the Information Strategy for details. Questions about any or all of the above? Please let me know. |
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