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C.H. Kawas, M.M. Corrada, R. Brookmeyer, A. Morrison, S.M. Resnick, A.B. Zonderman, and D. Arenberg

Visual Memory Predicts Alzheimer’s Disease more than a Decade before Diagnosis. (... this research was built upon other studies that have suggested that AD [Alzheimer’s Disease] may reflect a chronic process that begins many years before the clinical expression of dementia.
The authors tested 1,425 volunteers from the Baltimore Longitudinal Study of Aging [BLSA]--a multidisciplinary study of normal aging conducted by the [United States] National Institute on Aging; all study participants were older than 60 years of age. The study participants were given two tests--the Benton Visual Retention Test [BVRT] and Wechsler Adult Intelligence Scale–vocabulary [WAIS-voc]. The researchers used how well the study participants did on these tests in order to determine whether long-term deficits in these tests can predict the development of AD decades later.
Based on their findings, the authors concluded that a greater number of errors on the BVRT is associated with an increased risk of AD up to 15 years later [WAIS-voc scores were not significantly associated with the risk of AD in any time period]. Poor visual memory performance may represent an early expression of AD years before diagnosis. This result suggests the need to continue to revise views on the natural history of AD and the possibility of an increased window of opportunity for preventive treatment before definitive diagnosis -- from the text of the abstract)

Neurology Volume 60, Number 7 (April 8, 2003): 1089-1093.

**The complete text of the abstract is currently available through the Web site of Neurology**

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