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Author (up) Citron, M. file  url
doi  openurl
  Title Alzheimer's disease: treatments in discovery and development Type Journal Article
  Year 2002 Publication Nature Neuroscience Abbreviated Journal Nat Neurosci  
  Volume 5 Suppl Issue Pages 1055-1057  
  Keywords Alzheimer Disease/metabolism/physiopathology/*therapy; Amyloid beta-Peptides/*antagonists & inhibitors/biosynthesis; Animals; Brain/*drug effects/metabolism/physiopathology; Disease Models, Animal; *Drug Design; Drug Evaluation/trends; Drug Industry/trends; Enzyme Inhibitors/pharmacology/therapeutic use; Humans  
  Abstract Alzheimer's disease is the single biggest unmet medical need in neurology. Current drugs are safe, but of limited benefit to most patients. This review discusses the scientific basis and current status of promising disease-modifying therapies in the discovery and development stages. I describe the major targets of anti-amyloid therapy and the main focus of disease modification approaches. In addition, two new potential treatment approaches supported by retrospective epidemiology are outlined.  
  Call Number Serial 137  
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