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Record |
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Author  |
Danyuo, Y.; Obayemi, J.D.; Dozie-Nwachukwu, S.; Ani, C.J.; Odusanya, O.S.; Oni, Y.; Anuku, N.; Malatesta, K.; Soboyejo, W.O. |
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Title |
Prodigiosin release from an implantable biomedical device: kinetics of localized cancer drug release |
Type |
Journal Article |
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Year |
2014 |
Publication |
Materials Science & Engineering. C, Materials for Biological Applications |
Abbreviated Journal |
Mater Sci Eng C Mater Biol Appl |
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Volume |
42 |
Issue |
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Pages |
734-745 |
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Keywords |
Acrylic Resins/chemistry; Antineoplastic Agents/chemistry/*pharmacokinetics; Chemistry, Pharmaceutical/instrumentation; Diffusion; Drug Delivery Systems/instrumentation; Drug Liberation; Drug Therapy/*instrumentation; Hydrogels/chemistry; Hyperthermia, Induced; Kinetics; Prodigiosin/chemistry/*pharmacokinetics; *Prostheses and Implants; Biomedical device; Breast cancer; Hyperthermia; Localized chemotherapy; Poly(N-Isopropylacrylamide)-based hydrogels; Prodigiosin |
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Abstract |
This paper presents an implantable encapsulated structure that can deliver localized heating (hyperthermia) and controlled concentrations of prodigiosin (a cancer drug) synthesized by bacteria (Serratia marcesce (subsp. marcescens)). Prototypical Poly-di-methyl-siloxane (PDMS) packages, containing well-controlled micro-channels and drug storage compartments, were fabricated along with a drug-storing polymer produced by free radical polymerization of Poly(N-isopropylacrylamide)(PNIPA) co-monomers of Acrylamide (AM) and Butyl-methacrylate (BMA). The mechanisms of drug diffusion of PNIPA-base gels were elucidated. Scanning Electron Microscopy (SEM) was also used to study the heterogeneous porous structure of the PNIPA-based gels. The release exponents, n, of the gels were found to between 0.5 and 0.7. This is in the range expected for Fickian (n=0.5). Deviation from Fickian diffusion was also observed (n>0.5) diffusion. The gel diffusion coefficients were shown to vary between 2.1x10(-12)m(2)/s and 4.8x10(-6)m(2)/s. The implications of the results are then discussed for the localized treatment of cancer via hyperthermia and the controlled delivery of prodigiosin from encapsulated PNIPA-based devices. |
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Call Number |
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Serial |
1605 |
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