||Buckland, G.; Gonzalez, C.A.; Agudo, A.; Vilardell, M.; Berenguer, A.; Amiano, P.; Ardanaz, E.; Arriola, L.; Barricarte, A.; Basterretxea, M.; Chirlaque, M.D.; Cirera, L.; Dorronsoro, M.; Egues, N.; Huerta, J.M.; Larranaga, N.; Marin, P.; Martinez, C.; Molina, E.; Navarro, C.; Quiros, J.R.; Rodriguez, L.; Sanchez, M.-J.; Tormo, M.-J.; Moreno-Iribas, C.
||Adherence to the Mediterranean diet and risk of coronary heart disease in the Spanish EPIC Cohort Study
||American Journal of Epidemiology
||Am J Epidemiol
||Adult; Aged; Body Weights and Measures; Coronary Disease/*epidemiology; *Diet, Mediterranean; Female; Health Behavior; Humans; Male; Middle Aged; Prospective Studies; Risk Factors; Sex Factors; Socioeconomic Factors; Spain/epidemiology
||No known cohort study has investigated whether the Mediterranean diet can reduce incident coronary heart disease (CHD) events in a Mediterranean population. This study examined the relation between Mediterranean diet adherence and risk of incident CHD events in the 5 Spanish centers of the European Prospective Investigation into Cancer and Nutrition. Analysis included 41,078 participants aged 29-69 years, recruited in 1992-1996 and followed up until December 2004 (mean follow-up:10.4 years). Confirmed incident fatal and nonfatal CHD events were analyzed according to Mediterranean diet adherence, measured by using an 18-unit relative Mediterranean diet score. A total of 609 participants (79% male) had a fatal or nonfatal confirmed acute myocardial infarction (n = 468) or unstable angina requiring revascularization (n = 141). After stratification by center and age and adjustment for recognized CHD risk factors, high compared with low relative Mediterranean diet score was associated with a significant reduction in CHD risk (hazard ratio = 0.60, 95% confidence interval: 0.47, 0.77). A 1-unit increase in relative Mediterranean diet score was associated with a 6% reduced risk of CHD (95% confidence interval: 0.91, 0.97), with similar risk reductions by sex. Mediterranean diet adherence was associated with a significantly reduced CHD risk in this Mediterranean country, supporting its role in primary prevention of CHD in healthy populations.
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