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Author (up) Brzustewicz, E.; Bryl, E. file  url
  Title The role of cytokines in the pathogenesis of rheumatoid arthritis--Practical and potential application of cytokines as biomarkers and targets of personalized therapy Type Journal Article
  Year 2015 Publication Cytokine Abbreviated Journal Cytokine  
  Volume 76 Issue 2 Pages 527-536  
  Keywords Antibodies, Monoclonal/therapeutic use; Arthritis, Rheumatoid/drug therapy/*physiopathology; Biomarkers/*metabolism; Cytokines/*physiology; Humans; *Precision Medicine; Biological treatment; Biomarker; Cytokines; Rheumatoid arthritis; bDMARD  
  Abstract Rheumatoid arthritis (RA), as a common chronic disease leading to severe disability, requires early diagnosis and introduction of proper treatment. Deregulation in the cytokine network plays an undoubtedly crucial role in the pathogenesis of RA. The understanding of the role of cytokines in RA can be used for patients' benefit. Technological advances had already allowed introduction of the tailor-made cytokine-targeted therapies (so far anti-TNF, anti-IL-1 and anti-IL-6) into clinical practice. This type of treatment is currently developing very fast. Moreover, cytokines are considered to be potential powerful biomarkers of RA with roles predicted to grow in the future. Detailed understanding of the cytokine balance in RA may assist both the diagnostic process and therapy.  
  Call Number Serial 1914  
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Author (up) Buchanan, C.M.; Maccoby, E.E.; Dornbusch, S.M. file  url
  Title Caught between parents: adolescents' experience in divorced homes Type Journal Article
  Year 1991 Publication Child Development Abbreviated Journal Child Dev  
  Volume 62 Issue 5 Pages 1008-1029  
  Keywords Adaptation, Psychological; Adolescent; *Adolescent Psychology; Antisocial Personality Disorder/psychology; Anxiety/psychology; Depression/psychology; Divorce/*psychology; Female; Humans; Male; *Parent-Child Relations; Parenting/psychology; *Personality Development; Social Environment  
  Abstract This study examined adolescents' feelings of being caught between parents to see whether this construct helps to explain (1) variability in their postdivorce adjustment and (2) associations between family/child characteristics and adolescent adjustment. Adolescents 10 to 18 years old (N = 522) were interviewed by telephone 4 1/2 years after their parents' separation. Feeling caught between parents was related to high parental conflict and hostility and low parental cooperation. Being close to both parents was associated with low feelings of being caught. The relation between time spent with each parent and feeling caught depended on the coparenting relationship. Adolescents in dual residence were especially likely to feel caught when parents were in high conflict, and especially unlikely to feel caught when parents cooperated. Feeling caught was related to poor adjustment outcomes. Parental conflict was only related to adjustment outcomes indirectly, through adolescents' feelings of being caught.  
  Call Number Serial 281  
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Author (up) Buchanan, K.E.; Bardi, A. file  url
doi  openurl
  Title Acts of kindness and acts of novelty affect life satisfaction Type Journal Article
  Year 2010 Publication The Journal of Social Psychology Abbreviated Journal J Soc Psychol  
  Volume 150 Issue 3 Pages 235-237  
  Keywords Adolescent; Adult; *Altruism; *Exploratory Behavior; Female; Habituation, Psychophysiologic; Happiness; Humans; Male; Middle Aged; *Personal Satisfaction; Young Adult  
  Abstract The present experiment was designed to establish the effects of acts of kindness and acts of novelty on life satisfaction. Participants aged 18-60 took part on a voluntary basis. They were randomly assigned to perform either acts of kindness, acts of novelty, or no acts on a daily basis for 10 days. Their life satisfaction was measured before and after the 10-day experiment. As expected, performing acts of kindness or acts of novelty resulted in an increase in life satisfaction.  
  Call Number Serial 367  
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Author (up) Buckland, G.; Gonzalez, C.A.; Agudo, A.; Vilardell, M.; Berenguer, A.; Amiano, P.; Ardanaz, E.; Arriola, L.; Barricarte, A.; Basterretxea, M.; Chirlaque, M.D.; Cirera, L.; Dorronsoro, M.; Egues, N.; Huerta, J.M.; Larranaga, N.; Marin, P.; Martinez, C.; Molina, E.; Navarro, C.; Quiros, J.R.; Rodriguez, L.; Sanchez, M.-J.; Tormo, M.-J.; Moreno-Iribas, C. file  url
doi  openurl
  Title Adherence to the Mediterranean diet and risk of coronary heart disease in the Spanish EPIC Cohort Study Type Journal Article
  Year 2009 Publication American Journal of Epidemiology Abbreviated Journal Am J Epidemiol  
  Volume 170 Issue 12 Pages 1518-1529  
  Keywords Adult; Aged; Body Weights and Measures; Coronary Disease/*epidemiology; *Diet, Mediterranean; Female; Health Behavior; Humans; Male; Middle Aged; Prospective Studies; Risk Factors; Sex Factors; Socioeconomic Factors; Spain/epidemiology  
  Abstract No known cohort study has investigated whether the Mediterranean diet can reduce incident coronary heart disease (CHD) events in a Mediterranean population. This study examined the relation between Mediterranean diet adherence and risk of incident CHD events in the 5 Spanish centers of the European Prospective Investigation into Cancer and Nutrition. Analysis included 41,078 participants aged 29-69 years, recruited in 1992-1996 and followed up until December 2004 (mean follow-up:10.4 years). Confirmed incident fatal and nonfatal CHD events were analyzed according to Mediterranean diet adherence, measured by using an 18-unit relative Mediterranean diet score. A total of 609 participants (79% male) had a fatal or nonfatal confirmed acute myocardial infarction (n = 468) or unstable angina requiring revascularization (n = 141). After stratification by center and age and adjustment for recognized CHD risk factors, high compared with low relative Mediterranean diet score was associated with a significant reduction in CHD risk (hazard ratio = 0.60, 95% confidence interval: 0.47, 0.77). A 1-unit increase in relative Mediterranean diet score was associated with a 6% reduced risk of CHD (95% confidence interval: 0.91, 0.97), with similar risk reductions by sex. Mediterranean diet adherence was associated with a significantly reduced CHD risk in this Mediterranean country, supporting its role in primary prevention of CHD in healthy populations.  
  Call Number Serial 135  
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Author (up) Buffet-Bataillon, S.; Rabier, V.; Betremieux, P.; Beuchee, A.; Bauer, M.; Pladys, P.; Le Gall, E.; Cormier, M.; Jolivet-Gougeon, A. file  url
  Title Outbreak of Serratia marcescens in a neonatal intensive care unit: contaminated unmedicated liquid soap and risk factors Type Journal Article
  Year 2009 Publication The Journal of Hospital Infection Abbreviated Journal J Hosp Infect  
  Volume 72 Issue 1 Pages 17-22  
  Keywords Bacterial Typing Techniques; Case-Control Studies; Cross Infection/*epidemiology/microbiology; DNA Fingerprinting; DNA, Bacterial/genetics; *Disease Outbreaks; Electrophoresis, Gel, Pulsed-Field; *Environmental Microbiology; Female; Genotype; Hand Disinfection/methods; Humans; Infant, Newborn; Infection Control/methods; Intensive Care Units, Neonatal; Male; Risk Factors; Serratia Infections/*epidemiology/microbiology; Serratia marcescens/classification/genetics/*isolation & purification; *Soaps  
  Abstract This study describes an outbreak of Serratia marcescens and its investigation and control in a neonatal intensive care unit (NICU). During a three-month period, five infants were colonised or infected by a single strain of S. marcescens. A case-control study, culture surveys and pulse-field gel electrophoresis analysis implicated a bottle soap dispenser as a reservoir of S. marcescens (P=0.032). Infants with S. marcescens colonisation or infection were also more likely to have been exposed to a central or percutaneous venous catheter (P=0.05) and had had longer exposure to endotracheal intubation (P=0.05). Soap dispensers are used in many hospitals and may be an unrecognised source of nosocomial infections. This potential source of infection could be reduced by using 'airless' dispensers which have no air intake for the distribution of soap. Prompt intervention and strict adherence to alcoholic hand disinfection were the key factors that led to the successful control of this outbreak.  
  Call Number Serial 1655  
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Author (up) Buguet, A. file  url
doi  openurl
  Title Sleep under extreme environments: effects of heat and cold exposure, altitude, hyperbaric pressure and microgravity in space Type Journal Article
  Year 2007 Publication Journal of the Neurological Sciences Abbreviated Journal J Neurol Sci  
  Volume 262 Issue 1-2 Pages 145-152  
  Keywords Adaptation, Physiological/physiology; Atmospheric Pressure; *Climate; Cold Temperature/adverse effects; *Environment; Hot Temperature/adverse effects; Humans; Sleep/*physiology; Sleep Wake Disorders/etiology/*physiopathology; Space Flight; Weightlessness/adverse effects  
  Abstract Human sleep is sensitive to the individual's environment. The present review examines current knowledge of human sleep patterns under different environments: heat exposure, cold exposure, altitude, high pressure and microgravity in space. Heat exposure has two effects. In people living in temperate conditions, moderate heat loads (hot bath, sauna) prior to sleep provoke a delayed reaction across time (diachronic reaction) whereby slow-wave sleep (SWS) augments in the following night (neurogenic adaptive pathway). Melanoids and Caucasians living in the Sahel dry tropical climate experience diachronic increases in SWS throughout seasonal acclimatization. Such increases are greater during the hot season, being further enhanced after daytime exercise. On the contrary, when subjects are acutely exposed to heat, diachronic decreases in total sleep time and SWS occur, being often accompanied by synchronic (concomitant) diminution in REM sleep. Stress hormones increase. Nocturnal cold exposure provokes a synchronic decrease in REM sleep along with an activation of stress hormones (synchronic somatic reaction). SWS remains undisturbed as it still occurs at the beginning of the night before nocturnal body cooling. Altitude and high pressure are deleterious to sleep, especially in non-acclimatized individuals. In their controlled environment, astronauts can sleep well in microgravity. Exercise-induced sleep changes help to understand environmental effects on sleep: well-tolerated environmental strains may improve sleep through a neurogenic adaptive pathway; when this “central” adaptive pathway is overloaded or bypassed, diachronic and synchronic sleep disruptions occur.  
  Call Number Serial 1141  
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Author (up) Burak, M.F.; Inouye, K.E.; White, A.; Lee, A.; Tuncman, G.; Calay, E.S.; Sekiya, M.; Tirosh, A.; Eguchi, K.; Birrane, G.; Lightwood, D.; Howells, L.; Odede, G.; Hailu, H.; West, S.; Garlish, R.; Neale, H.; Doyle, C.; Moore, A.; Hotamisligil, G.S. file  url
  Title Development of a therapeutic monoclonal antibody that targets secreted fatty acid-binding protein aP2 to treat type 2 diabetes Type Journal Article
  Year 2015 Publication Science Translational Medicine Abbreviated Journal Sci Transl Med  
  Volume 7 Issue 319 Pages 319ra205  
  Keywords Adipose Tissue/drug effects; Amino Acid Sequence; Animals; Antibodies, Monoclonal/*therapeutic use; Body Composition/drug effects; Diabetes Mellitus, Type 2/complications/*drug therapy; Diet, High-Fat; Fatty Acid-Binding Proteins/chemistry/*immunology; Fatty Liver/complications/pathology; Glucose/metabolism; Humans; Insulin/pharmacology; Male; Metabolome/drug effects; Mice, Inbred C57BL; Mice, Obese  
  Abstract The lipid chaperone aP2/FABP4 has been implicated in the pathology of many immunometabolic diseases, including diabetes in humans, but aP2 has not yet been targeted for therapeutic applications. aP2 is not only an intracellular protein but also an active adipokine that contributes to hyperglycemia by promoting hepatic gluconeogenesis and interfering with peripheral insulin action. Serum aP2 levels are markedly elevated in mouse and human obesity and strongly correlate with metabolic complications. These observations raise the possibility of a new strategy to treat metabolic disease by targeting serum aP2 with a monoclonal antibody (mAb) to aP2. We evaluated mAbs to aP2 and identified one, CA33, that lowered fasting blood glucose, improved systemic glucose metabolism, increased systemic insulin sensitivity, and reduced fat mass and liver steatosis in obese mouse models. We examined the structure of the aP2-CA33 complex and resolved the target epitope by crystallographic studies in comparison to another mAb that lacked efficacy in vivo. In hyperinsulinemic-euglycemic clamp studies, we found that the antidiabetic effect of CA33 was predominantly linked to the regulation of hepatic glucose output and peripheral glucose utilization. The antibody had no effect in aP2-deficient mice, demonstrating its target specificity. We conclude that an aP2 mAb-mediated therapeutic constitutes a feasible approach for the treatment of diabetes.  
  Call Number Serial 2042  
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Author (up) Burg, M.M.; Barefoot, J.; Berkman, L.; Catellier, D.J.; Czajkowski, S.; Saab, P.; Huber, M.; DeLillo, V.; Mitchell, P.; Skala, J.; Taylor, C.B. file  url
  Title Low perceived social support and post-myocardial infarction prognosis in the enhancing recovery in coronary heart disease clinical trial: the effects of treatment Type Journal Article
  Year 2005 Publication Psychosomatic Medicine Abbreviated Journal Psychosom Med  
  Volume 67 Issue 6 Pages 879-888  
  Keywords Cognitive Therapy; Cohort Studies; Comorbidity; Coronary Disease/*drug therapy/mortality; Depressive Disorder/diagnosis/epidemiology/therapy; Female; Follow-Up Studies; Humans; Male; Mortality; Myocardial Infarction/*diagnosis/epidemiology/therapy; Outcome Assessment (Health Care); Prognosis; Proportional Hazards Models; Risk Factors; Secondary Prevention; *Social Support; Spouses/statistics & numerical data; Treatment Outcome  
  Abstract OBJECTIVE: In post hoc analyses, to examine in low perceived social support (LPSS) patients enrolled in the Enhancing Recovery in Coronary Heart Disease (ENRICHD) clinical trial (n = 1503), the pattern of social support following myocardial infarction (MI), the impact of psychosocial intervention on perceived support, the relationship of perceived support at the time of MI to subsequent death and recurrent MI, and the relationship of change in perceived support 6 months after MI to subsequent mortality. METHODS: Partner status (partner, no partner) and score (<12 = low support; >12 = moderate support) on the ENRICHD Social Support Instrument (ESSI) were used post hoc to define four levels of risk. The resulting 4 LPSS risk groups were compared on baseline characteristics, changes in social support, and medical outcomes to a group of concurrently enrolled acute myocardial infarction patients without depression or LPSS (MI comparison group, n = 408). Effects of treatment assignment on LPSS and death/recurrent MI were also examined. RESULTS: All 4 LPSS risk groups demonstrated improvement in perceived support, regardless of treatment assignment, with a significant treatment effect only seen in the LPSS risk group with no partner and moderate support at baseline. During an average 29-month follow-up, the combined end point of death/nonfatal MI was 10% in the MI comparison group and 23% in the ENRICHD LPSS patients; LPSS conferred a greater risk in unadjusted and adjusted models (HR = 1.74-2.39). Change in ESSI score and/or improvement in perceived social support were not found to predict subsequent mortality. CONCLUSIONS: Baseline LPSS predicted death/recurrent MI in the ENRICHD cohort, independent of treatment assignment. Intervention effects indicated a partner surrogacy role for the interventionist and the need for a moderate level of support at baseline for the intervention to be effective.  
  Call Number Serial 2057  
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Author (up) Burke, T.A.; Litt, J.S.; Fox, M.A. file  url
  Title Linking public health and the health of the Chesapeake Bay Type Journal Article
  Year 2000 Publication Environmental Research Abbreviated Journal Environ Res  
  Volume 82 Issue 2 Pages 143-149  
  Keywords *Environmental Health; Humans; Maryland; *Public Health; *Risk Management; Seawater; Water Pollution/*prevention & control  
  Abstract The Chesapeake Bay has a profound impact on the lives of all who reside in the 64,000 square miles of its watershed. From crab cakes to sail-boats, drinking water to naval ships, the Bay touches virtually every aspect of life in the region. The Bay has inspired literature, driven the regional economy, and shaped political decision making and development patterns for homes, industry, agriculture, and transportation. As population demands increase and urban boundaries expand into pristine landscapes, the sustainability of the Chesapeake Bay and its resources face unprecedented pressures. Consequently, the public's health also is vulnerable to Bay pollution and other stresses stemming from development activities and widespread growth occurring throughout the Chesapeake Bay watershed. This paper will examine the linkages between the environmental quality of the Bay and the population health status, recommend ways to bridge ecological and human health concerns in the context of the Bay, and finally present a framework for developing a public health report card for the Bay.  
  Call Number Serial 923  
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Author (up) Burt, S.A.; Barnes, A.R.; McGue, M.; Iacono, W.G. file  url
doi  openurl
  Title Parental divorce and adolescent delinquency: ruling out the impact of common genes Type Journal Article
  Year 2008 Publication Developmental Psychology Abbreviated Journal Dev Psychol  
  Volume 44 Issue 6 Pages 1668-1677  
  Keywords Adolescent; Adoption/psychology; Aggression/psychology; Antisocial Personality Disorder/epidemiology/*genetics/psychology; Causality; Conduct Disorder/epidemiology/*genetics/psychology; Cross-Sectional Studies; Divorce/*psychology/statistics & numerical data; Female; Genotype; Humans; Internal-External Control; Juvenile Delinquency/*psychology/statistics & numerical data; Male; Risk Factors; Sex Factors; *Social Environment  
  Abstract Although the well-documented association between parental divorce and adolescent delinquency is generally assumed to be environmental (i.e., causal) in origin, genetic mediation is also possible. Namely, the behavior problems often found in children of divorce could derive from similar pathology in the parents, pathology that is both heritable and increases the risk that the parent will experience divorce. To test these alternative hypotheses, the authors made use of a novel design that incorporated timing of divorce in a sample of 610 adoptive and biological families. They reasoned that if genes common to parent and child mediate this association, nonadopted youth should manifest increased delinquency in the presence of parental divorce even if the divorce preceded their birth (i.e., was from a prior parental relationship). However, should the association be environmental in origin, the authors reasoned that adolescents should manifest increased delinquency only in response to divorce exposure, and this association should not vary by adoption status. Results firmly supported the latter, suggesting that it is the experience of parental divorce, and not common genes, that drives the association between divorce and adolescent delinquency.  
  Call Number Serial 293  
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