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Author Broberg, D.J.; Bernstein, I.L. file  url
  Title Candy as a scapegoat in the prevention of food aversions in children receiving chemotherapy Type Journal Article
  Year 1987 Publication (up) Cancer Abbreviated Journal Cancer  
  Volume 60 Issue 9 Pages 2344-2347  
  Keywords Adolescent; Antineoplastic Agents/*adverse effects; *Avoidance Learning; *Candy; Child; Child, Preschool; Conditioning (Psychology); *Food Preferences; Humans; Nausea/chemically induced/*psychology  
  Abstract The effectiveness of a method for reducing the incidence of chemotherapy-induced learned food aversions was examined. Candy (coconut or rootbeer Lifesavers) was used as a scapegoat and given between the consumption of a meal and the administration of chemotherapy to determine whether this would lead to a greater willingness to consume items in that meal at a future test. This procedure produced evidence that the scapegoat had a significant protective effect: children were twice as likely to eat some portion of their test meal at the time of assessment if they had received the scapegoat at conditioning than when there was no intervention. Thus, the consumption of strongly flavored candies before chemotherapy appears to be a simple and effective way to reduce the impact of chemotherapy on preference for normal menu items.  
  Call Number Serial 219  
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Author Overholser, J.P.; Prewett, M.C.; Hooper, A.T.; Waksal, H.W.; Hicklin, D.J. file  url
  Title Epidermal growth factor receptor blockade by antibody IMC-C225 inhibits growth of a human pancreatic carcinoma xenograft in nude mice Type Journal Article
  Year 2000 Publication (up) Cancer Abbreviated Journal Cancer  
  Volume 89 Issue 1 Pages 74-82  
  Keywords Animals; Antibodies, Monoclonal/immunology/*pharmacology; Antibodies, Monoclonal, Humanized; Antimetabolites, Antineoplastic/pharmacology; Antineoplastic Agents/immunology/*pharmacology; Cell Division; Cell Survival; Cetuximab; DNA, Neoplasm/biosynthesis; Female; Fluorouracil/pharmacology; Humans; Ligands; Mice; Mice, Nude; Pancreatic Neoplasms/*pathology; Receptor, Epidermal Growth Factor/*physiology; Transplantation, Heterologous  
  Abstract BACKGROUND: Pancreatic carcinoma is associated with a poor prognosis, and treatment options for patients with this disease are limited. The epidermal growth factor (EGF) receptor and its ligands are overexpressed in human pancreatic carcinoma and may contribute to the pathophysiology of these tumors. METHODS: The anti-EGF receptor monoclonal antibody IMC-C225 was used to determine the effects of EGF receptor blockade on the growth of human pancreatic carcinoma BxPC-3 cells in vitro. Athymic mice bearing established (200 mm(3)) subcutaneous BxPC-3 xenografts were treated with IMC-C225 (17 or 33 mg/kg every 3 days) alone or in combination with 5-fluorouracil (17 mg/kg twice weekly). RESULTS: IMC-C225 inhibited exogenous ligand-stimulated tyrosine phosphorylation of the EGF receptor on BxPC-3 tumor cells. Treatment of BxPC-3 cells with IMC-C225 inhibited DNA synthesis (23.8%) and colony formation in soft agar (45.6%). IMC-C225 treatment significantly suppressed the growth of BxPC-3 tumors compared with treatment with vehicle alone (P = 0.003). Combination therapy with IMC-C225 and the chemotherapeutic agent 5-fluorouracil enhanced the antitumor effects compared with either agent alone and resulted in regression of pancreatic tumors in several animals. Histologic examination of pancreatic tumors from mice treated with IMC-C225 showed extensive tumor necrosis that coincided with a substantial decrease in tumor cell proliferation and an increase in tumor cell apoptosis. CONCLUSIONS: These data suggest that IMC-C225 affects the growth of pancreatic tumors by inhibiting EGF receptor-dependent proliferation and survival, and demonstrates the potential for therapeutic application of IMC-C225 antibody in the treatment of human pancreatic carcinoma.  
  Call Number Serial 2016  
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Author Schoenfeld, J.D.; Sibenaller, Z.A.; Mapuskar, K.A.; Wagner, B.A.; Cramer-Morales, K.L.; Furqan, M.; Sandhu, S.; Carlisle, T.L.; Smith, M.C.; Abu Hejleh, T.; Berg, D.J.; Zhang, J.; Keech, J.; Parekh, K.R.; Bhatia, S.; Monga, V.; Bodeker, K.L.; Ahmann, L.; Vollstedt, S.; Brown, H.; Shanahan Kauffman, E.P.; Schall, M.E.; Hohl, R.J.; Clamon, G.H.; Greenlee, J.D.; Howard, M.A.; Schultz, M.K.; Smith, B.J.; Riley, D.P.; Domann, F.E.; Cullen, J.J.; Buettner, G.R.; Buatti, J.M.; Spitz, D.R.; Allen, B.G. file  url
  Title O2(-) and H2O2-Mediated Disruption of Fe Metabolism Causes the Differential Susceptibility of NSCLC and GBM Cancer Cells to Pharmacological Ascorbate Type Journal Article
  Year 2017 Publication (up) Cancer Cell Abbreviated Journal Cancer Cell  
  Volume 31 Issue 4 Pages 487-500.e8  
  Keywords Animals; Antineoplastic Combined Chemotherapy Protocols/therapeutic use; Ascorbic Acid/administration & dosage/adverse effects/*pharmacology; Brain Neoplasms/*drug therapy; Carcinoma, Non-Small-Cell Lung/*drug therapy/metabolism/mortality/radiotherapy; Cell Line, Tumor; Chemoradiotherapy/methods; Female; Glioblastoma/*drug therapy/metabolism; Humans; Hydrogen Peroxide/pharmacology; Iron/*metabolism; Lung Neoplasms/*drug therapy/metabolism/mortality/radiotherapy; Male; Mice, Nude; Oxygen/metabolism; Radiation-Sensitizing Agents/pharmacology; Xenograft Model Antitumor Assays; ferritin; glioblastoma multiforme; hydrogen peroxide; labile iron metabolism; non-small cell lung cancer; oxidative stress; pharmacological ascorbate; superoxide; superoxide dismutase; transferrin receptor  
  Abstract Pharmacological ascorbate has been proposed as a potential anti-cancer agent when combined with radiation and chemotherapy. The anti-cancer effects of ascorbate are hypothesized to involve the autoxidation of ascorbate leading to increased steady-state levels of H2O2; however, the mechanism(s) for cancer cell-selective toxicity remain unknown. The current study shows that alterations in cancer cell mitochondrial oxidative metabolism resulting in increased levels of O2(-) and H2O2 are capable of disrupting intracellular iron metabolism, thereby selectively sensitizing non-small-cell lung cancer (NSCLC) and glioblastoma (GBM) cells to ascorbate through pro-oxidant chemistry involving redox-active labile iron and H2O2. In addition, preclinical studies and clinical trials demonstrate the feasibility, selective toxicity, tolerability, and potential efficacy of pharmacological ascorbate in GBM and NSCLC therapy.  
  Call Number Serial 2122  
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Author Billings, P.C.; Engelsberg, B.N.; Hughes, E.N. file  url
  Title Proteins binding to cisplatin-damaged DNA in human cell lines Type Journal Article
  Year 1994 Publication (up) Cancer Investigation Abbreviated Journal Cancer Invest  
  Volume 12 Issue 6 Pages 597-604  
  Keywords Cell Nucleus/metabolism; Cisplatin/*metabolism/*toxicity; DNA Adducts/*metabolism; *DNA Damage; DNA, Neoplasm/*drug effects/*metabolism; DNA-Binding Proteins/*metabolism; HeLa Cells; Humans; Neoplasm Proteins/metabolism; Protein Binding  
  Abstract Cisplatin (CDDP) is a highly effective, frequently used cancer chemotherapeutic drug employed in the treatment of several human malignancies including ovarian, testicular, and bladder cancers. A common problem encountered with cisplatin therapy is intrinsic or acquired resistance to this drug. While the mechanisms of resistance to cisplatin, and other chemotherapeutic agents, are not fully understood, one factor affecting the cellular response to CDDP may result from differences in the level of specific proteins that recognize CDDP-damaged DNA. We have developed a damaged DNA affinity precipitation technique that allows the direct visualization and characterization of cellular proteins that bind to cisplatin-damaged DNA. In the present study we have utilized this method to analyze proteins present in several mammalian cell lines that bind to cisplatin-damaged DNA. We demonstrate that HeLa cells, resistant to CDDP cytotoxicity, contain high levels of high-mobility-group proteins 1 and 2, which bind to CDDP-DNA. We also show that xeroderma pigmentosum cells of different genetic complementation groups contain variable levels of a 45-kDa protein that binds to CDDP-DNA. Thus, our results indicate that different human cell lines demonstrate qualitative and quantitative differences in the expression of cisplatin-damaged DNA binding proteins.  
  Call Number Serial 195  
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Author Kang, Y.H.; Lee, K.-A.; Ryu, C.J.; Lee, H.-G.; Lim, J.-S.; Park, S.N.; Paik, S.-G.; Yoon, D.-Y. file  url
doi  openurl
  Title Mitomycin C induces apoptosis via Fas/FasL dependent pathway and suppression of IL-18 in cervical carcinoma cells Type Journal Article
  Year 2006 Publication (up) Cancer Letters Abbreviated Journal Cancer Lett  
  Volume 237 Issue 1 Pages 33-44  
  Keywords Antibiotics, Antineoplastic/*pharmacology; Antigens, CD95; Antineoplastic Agents/*pharmacology; *Apoptosis; Caspase 3; Caspase 8; Caspases/metabolism; Cell Line, Tumor; Cell Survival/drug effects; Cisplatin/pharmacology; Fas Ligand Protein; Female; Humans; I-kappa B Proteins/antagonists & inhibitors/metabolism; Interleukin-18/antagonists & inhibitors/*metabolism; Membrane Glycoproteins/*metabolism; Mitomycin/*pharmacology; Oncogene Proteins, Viral/genetics; Receptors, Tumor Necrosis Factor/*metabolism; Repressor Proteins/genetics; Signal Transduction/*drug effects; Transfection; Tumor Necrosis Factors/*metabolism; Uterine Cervical Neoplasms  
  Abstract Mitomycin C (MMC) is used fairly widely as an anticancer drug, as it possesses mechanisms of action which are preferable to other chemotherapeutic compounds, including cisplatin, docetaxel, and lovastatin. In the previous study, we established the RSV-luc promoter analysis system, which is used to screen drugs against cervical carcinomas caused by HPV infection. We then demonstrated the repression of HPV E6-activated RSV promoter activity by anticancer agents such as carboplatin (CA), cisplatin (CIS), and MMC. In these studies, we focused on the investigation of apoptotic mechanisms in MMC-treated cervical carcinoma cell lines, most notably SiHa/pRSV-luc (KCTC 0427BP) and SiHa. DNA fragmentation assays and TUNEL staining revealed that MMC and CIS, but not CA, resulted in apoptosis. MMC treatment induced a reduction in the expressions of the E6 oncogene and IL-18, in a p53-independent manner. MMC also increased FasL expression and induced the processing of caspases-8 and -3. Our results indicated that MMC induced apoptosis in SiHa/pRSV-luc and SiHa cells via caspase-8 and -3 processing, in a Fas/FasL-dependent manner. MMC also suppressed the expression of IL-18 in the same cells. MMC also down-regulated IkappaB expression, and up-regulated p65 expression. These results suggest that MMC induces apoptosis, not only through caspase-8 and -3 dependent Fas/FasL pathway, but also via the regulation of NF-kappaB activity and IL-18 expression.  
  Call Number Serial 198  
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Author Fearon, E.R.; Vogelstein, B. file  url
  Title A genetic model for colorectal tumorigenesis Type Journal Article
  Year 1990 Publication (up) Cell Abbreviated Journal Cell  
  Volume 61 Issue 5 Pages 759-767  
  Keywords Alleles; Chromosome Deletion; Colorectal Neoplasms/*genetics; Heterozygote; Humans; Models, Genetic; Mutation; Oncogenes/genetics; Suppression, Genetic  
  Call Number Serial 1723  
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Author Missiaen, L.; Dode, L.; Vanoevelen, J.; Raeymaekers, L.; Wuytack, F. file  url
  Title Calcium in the Golgi apparatus Type Journal Article
  Year 2007 Publication (up) Cell Calcium Abbreviated Journal Cell Calcium  
  Volume 41 Issue 5 Pages 405-416  
  Keywords Animals; Calcium--metabolism; Calcium-Transporting ATPases--genetics, metabolism; Golgi Apparatus--enzymology, metabolism; Humans; Pemphigus, Benign Familial--enzymology, genetics, pathology  
  Abstract The secretory-pathway Ca2+-ATPases (SPCAs) represent a recently recognized family of phosphorylation-type ATPases that supply the lumen of the Golgi apparatus with Ca2+ and Mn2+ needed for the normal functioning of this structure. Mutations of the human SPCA1 gene (ATP2C1) cause Hailey-Hailey disease, an autosomal dominant skin disorder in which keratinocytes in the suprabasal layer of the epidermis detach. We will first review the physiology of the SPCAs and then discuss how mutated SPCA1 proteins can lead to an epidermal disorder.  
  Call Number Serial 792  
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Author Turnbaugh, P.J. file  url
  Title Microbes and Diet-Induced Obesity: Fast, Cheap, and Out of Control Type Journal Article
  Year 2017 Publication (up) Cell Host & Microbe Abbreviated Journal Cell Host Microbe  
  Volume 21 Issue 3 Pages 278-281  
  Keywords Animals; Cytosol/chemistry; Diet/*adverse effects/*methods; Gastrointestinal Microbiome/*drug effects; Humans; *Obesity; cellular memory; diet-induced obesity; gut microbiome; high-fat and high-sugar diets; metabolic disease; metagenomics; metatranscriptomics; microbial dynamics; multi-omics; nutrition  
  Abstract Here I revisit our early experiments published in Cell Host & Microbe (Turnbaugh et al., 2008) showing that a diet rich in fat and simple sugars alters the gut microbiome in a manner that contributes to host adiposity, and reflect upon the remarkable advances and remaining challenges in this field.  
  Call Number Serial 2090  
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Author Fisone, G.; Borgkvist, A.; Usiello, A. file  url
doi  openurl
  Title Caffeine as a psychomotor stimulant: mechanism of action Type Journal Article
  Year 2004 Publication (up) Cellular and Molecular Life Sciences : CMLS Abbreviated Journal Cell Mol Life Sci  
  Volume 61 Issue 7-8 Pages 857-872  
  Keywords *Adenosine A1 Receptor Antagonists; *Adenosine A2 Receptor Antagonists; Animals; Basal Ganglia/cytology/metabolism; Caffeine/*metabolism/*pharmacology; Central Nervous System Stimulants/*metabolism; Dopamine/metabolism; Dopamine and cAMP-Regulated Phosphoprotein 32; Enzyme Inhibitors/metabolism; Humans; Motor Activity/*drug effects; *Nerve Tissue Proteins; Neurons/metabolism; Neuroprotective Agents/metabolism; Parkinson Disease/metabolism; Phosphoproteins/metabolism; Receptor, Adenosine A1/metabolism; Receptor, Adenosine A2A/metabolism; Receptors, Dopamine D2/metabolism; Signal Transduction; Synaptic Transmission/physiology  
  Abstract The popularity of caffeine as a psychoactive drug is due to its stimulant properties, which depend on its ability to reduce adenosine transmission in the brain. Adenosine A(1) and A(2A) receptors are expressed in the basal ganglia, a group of structures involved in various aspects of motor control. Caffeine acts as an antagonist to both types of receptors. Increasing evidence indicates that the psychomotor stimulant effect of caffeine is generated by affecting a particular group of projection neurons located in the striatum, the main receiving area of the basal ganglia. These cells express high levels of adenosine A(2A) receptors, which are involved in various intracellular processes, including the expression of immediate early genes and regulation of the dopamine- and cyclic AMP-regulated 32-kDa phosphoprotein DARPP-32. The present review focuses on the effects of caffeine on striatal signal transduction and on their involvement in caffeine-mediated motor stimulation.  
  Call Number Serial 215  
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Author Foote, H.W.; Hamer, J.D.; Roland, M.M.; Landy, S.R.; Smitherman, T.A. file  url
  Title Psychological flexibility in migraine: A study of pain acceptance and values-based action Type Journal Article
  Year 2016 Publication (up) Cephalalgia : an International Journal of Headache Abbreviated Journal Cephalalgia  
  Volume 36 Issue 4 Pages 317-324  
  Keywords *Adaptation, Psychological; Adult; Chronic Pain/psychology; Cross-Sectional Studies; Female; Humans; Male; Migraine Disorders/*psychology; Surveys and Questionnaires; Migraine; acceptance; acceptance and commitment therapy; disability; headache; psychological flexibility  
  Abstract BACKGROUND: Studies of musculoskeletal pain patients confirm that acceptance of pain and values-based action are strong predictors of pain-related disability and that interventions fostering “psychological flexibility” confer positive outcomes. However, data on these processes in migraine remain limited. This cross-sectional study examined relations between components of psychological flexibility and headache among treatment-seeking migraineurs. METHODS: A total of 103 adults (M age = 41.5 (11.9) years; 88.2% female) with ICHD-confirmed migraine (71.8% episodic, 28.2% chronic) across three clinics completed measures of psychological flexibility and headache-related disability. Hierarchical regressions quantified relations between acceptance/values-based action and headache variables after first controlling for pain severity and gender. RESULTS: Acceptance of pain and values-based action accounted for 10% of unique variance in headache severity (DeltaR(2) p = 0.006) and up to 20% in headache-related disability (DeltaR(2) ps = 0.02 and < 0.001) but were weakly related to headache frequency. Psychological flexibility was more strongly associated with MIDAS-measured disability than was headache severity or headache frequency. Significant effects were typically of medium-to-large size and driven primarily by values-based action. CONCLUSIONS: Paralleling results from the broader chronic pain literature, pain acceptance and values-based action play significant roles in headache pain and disability. Further study of interventions targeting these processes may enhance existing treatments.  
  Call Number Serial 2062  
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