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Author Stasi, R. file  url
  Title Immune thrombocytopenia: pathophysiologic and clinical update Type Journal Article
  Year 2012 Publication Seminars in Thrombosis and Hemostasis Abbreviated Journal Semin Thromb Hemost  
  Volume 38 Issue 5 Pages 454-462  
  Keywords Autoantibodies/*immunology; Blood Platelets/*immunology; Humans; Thrombocytopenia/blood/immunology/*physiopathology  
  Abstract Immune thrombocytopenia (ITP) is an autoimmune disorder characterized by both reduced platelet survival and suppression of megakaryocyte and platelet development. It can either be primary or secondary to other autoimmune disorders, infections, vaccines, lymphoproliferative disorders, and drugs. Antibodies reacting against platelet glycoproteins are typical of ITP; these antibodies can mediate destruction of platelets by the monocyte-macrophage system as well as suppress megakaryocyte proliferation and maturation. Abnormalities of cell-mediated immunity are known to contribute to the pathologic process. Like many other autoimmune diseases, ITP has a T helper cell type 1 bias and a reduced activity of T-regulatory cells. Cytotoxic T cells may directly lyse platelets and possibly suppress megakaryopoiesis. Recent studies suggest that mesenchymal stem cells are dysfunctional in ITP and may contribute to an aberrant amplification of the autoimmune response. Significant advances in the treatment of chronic ITP have been witnessed in the past decade, first with the introduction of rituximab and more recently with the thrombopoietin-receptor agonists. While splenectomy is still considered the gold standard in this setting, effective medical therapy is now available for patients in whom surgery is not an option.  
  Call Number Serial 1913  
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Author Izumi, B.T.; Alaimo, K.; Hamm, M.W. file  url
  Title Farm-to-school programs: perspectives of school food service professionals Type Journal Article
  Year 2010 Publication Journal of Nutrition Education and Behavior Abbreviated Journal J Nutr Educ Behav  
  Volume 42 Issue 2 Pages 83-91  
  Keywords Administrative Personnel/*psychology; Adult; *Agriculture; *Attitude to Health; Child; Child Nutritional Physiological Phenomena/physiology; Costs and Cost Analysis; Crops, Agricultural/economics/standards; Female; *Food Services/organization & administration; Fruit/economics/supply & distribution; Humans; Interviews as Topic; Male; *Motivation; Schools; Students/psychology; Vegetables/economics/supply & distribution; Workforce  
  Abstract OBJECTIVE: This qualitative study used a case study approach to explore the potential of farm-to-school programs to simultaneously improve children's diets and provide farmers with viable market opportunities. DESIGN: Semistructured interviews were the primary data collection strategy. SETTING: Seven farm-to-school programs in the Upper Midwest and Northeast regions of the United States. PARTICIPANTS: Seven school food service professionals, 7 farmers, and 4 food distributors recruited from 7 farm-to-school programs. PHENOMENON OF INTEREST: Interviews probed why farmers, school food service professionals, and food distributors participate in farm-to-school programs and how they characterize the opportunities and challenges to local school food procurement. ANALYSIS: Data were analyzed using thematic coding and data displays. RESULTS: School food service professionals described 3 motivators for buying locally grown food for their cafeterias: (1) “The students like it,” (2) “The price is right,” and (3) “We're helping our local farmer.” Students' preference for locally grown food was related to food quality, influence of school staff, and relationships with farmers. Buying food directly from farmers and wholesalers was associated with lower prices and flexible specifications, and the “local feel.” CONCLUSIONS AND IMPLICATIONS: Understanding school food service professionals' motivations for buying locally grown food is critical to the sustainability of farm-to-school programs.

Subject headings: administrative personnel/*psychology; adult; *agriculture; *attitude to health; child; child nutritional physiological phenomena/physiology; costs and cost analysis; crops, agricultural/economics/standards; female; *food services/organization & administration; fruit/economics/supply & distribution; humans; interviews as topic; male; *motivation; schools; students/psychology; vegetables/economics/supply & distribution; workforce

Keywords: farm-to-school programs: perspectives of school food service professionals
  Call Number Serial 2919  
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Author Teuber, M. file  url
  Title Veterinary use and antibiotic resistance Type Journal Article
  Year 2001 Publication Current Opinion in Microbiology Abbreviated Journal Curr Opin Microbiol  
  Volume 4 Issue 5 Pages 493-499  
  Keywords Agriculture; Animals; *Animals, Domestic; Anti-Bacterial Agents/administration & dosage/*pharmacology/therapeutic use; Bacteria/*drug effects; *Drug Resistance, Bacterial; Drug Utilization; Humans; *Veterinary Drugs; *Veterinary Medicine  
  Abstract Globally, an estimated 50% of all antimicrobials serve veterinary purposes. Bacteria that inevitably develop antibiotic resistance in animals comprise food-borne pathogens, opportunistic pathogens and commensal bacteria. The same antibiotic resistance genes and gene transfer mechanisms can be found in the microfloras of animals and humans. Direct contact, food and water link animal and human habitats. The accumulation of resistant bacteria by the use of antibiotics in agriculture and veterinary medicine and the spread of such bacteria via agriculture and direct contamination are documented.  
  Call Number Serial 1671  
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Author Joshi, S.V.; Hartley, S.N.; Kessler, M.; Barstead, M. file  url
  Title School-based suicide prevention: content, process, and the role of trusted adults and peers Type Journal Article
  Year 2015 Publication Child and Adolescent Psychiatric Clinics of North America Abbreviated Journal Child Adolesc Psychiatr Clin N Am  
  Volume 24 Issue 2 Pages 353-370  
  Keywords Adolescent; Adolescent Behavior; Humans; Mental Disorders/*psychology; Peer Group; Preventive Health Services/*methods; Risk-Taking; *School Health Services; Students/*psychology; Suicide/*prevention & control; Child/adolescent; High-risk behaviors; School mental health; School-based suicide prevention; Suicide prevention; Suicide/self-harm; Supporting alliance  
  Abstract Suicide is a leading cause of preventable death in youth, and numerous curricula and other prevention and intervention programs have been developed in the last 15 years. Comprehensive suicide prevention planning should include the 4 components of health promotion, prevention/education, intervention, and postvention. School-based suicide prevention and mental health education programs have become more common as an efficient and cost-effective way to reach youth. Process considerations that are based on the principles of therapeutic engagement with patients and families can provide mental health professionals with strategies that can assist education professionals, students, and the larger school community simultaneously.  
  Call Number Serial 2169  
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Author Wilens, T.E.; Biederman, J.; Kwon, A.; Ditterline, J.; Forkner, P.; Moore, H.; Swezey, A.; Snyder, L.; Henin, A.; Wozniak, J.; Faraone, S.V. file  url
  Title Risk of substance use disorders in adolescents with bipolar disorder Type Journal Article
  Year 2004 Publication Journal of the American Academy of Child and Adolescent Psychiatry Abbreviated Journal J Am Acad Child Adolesc Psychiatry  
  Volume 43 Issue 11 Pages 1380-1386  
  Keywords Adolescent; Adolescent Behavior; Bipolar Disorder/*complications/*psychology; Case-Control Studies; Child; Female; Humans; Male; Risk Factors; Substance-Related Disorders/*etiology/*psychology  
  Abstract OBJECTIVE: Previous work in adults and youths has suggested that juvenile onset bipolar disorder (BPD) is associated with an elevated risk of substance use disorders (SUD). Considering the public health importance of this issue, the authors now report on a controlled study of adolescents with and without BPD to evaluate the risk of SUD. METHOD: Probands with DSM-IV BPD (n=57, mean age +/- SD=13.3 +/- 2.4 years) and without DSM-IV BPD (n=46, 13.6 +/- 2.2 years) were studied. Structured psychiatric interviews and multiple measures of SUD were collected. RESULTS: Bipolar disorder was associated with a highly significant risk factor for SUD (32% versus 7%, Z=2.9, p=.004) that was not accounted for by conduct disorder (adjusted odds ratio=5.4, p=.018). Adolescent-onset BPD (> or =13 years) was associated with a higher risk of SUD compared with those with child-onset BPD (chi1=9.3, p=.002). CONCLUSIONS: These findings strongly indicate that BPD, especially adolescent onset, is a significant risk factor for SUD independently of conduct disorder.  
  Call Number Serial 2170  
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Author Buffet-Bataillon, S.; Rabier, V.; Betremieux, P.; Beuchee, A.; Bauer, M.; Pladys, P.; Le Gall, E.; Cormier, M.; Jolivet-Gougeon, A. file  url
  Title Outbreak of Serratia marcescens in a neonatal intensive care unit: contaminated unmedicated liquid soap and risk factors Type Journal Article
  Year 2009 Publication The Journal of Hospital Infection Abbreviated Journal J Hosp Infect  
  Volume 72 Issue 1 Pages 17-22  
  Keywords Bacterial Typing Techniques; Case-Control Studies; Cross Infection/*epidemiology/microbiology; DNA Fingerprinting; DNA, Bacterial/genetics; *Disease Outbreaks; Electrophoresis, Gel, Pulsed-Field; *Environmental Microbiology; Female; Genotype; Hand Disinfection/methods; Humans; Infant, Newborn; Infection Control/methods; Intensive Care Units, Neonatal; Male; Risk Factors; Serratia Infections/*epidemiology/microbiology; Serratia marcescens/classification/genetics/*isolation & purification; *Soaps  
  Abstract This study describes an outbreak of Serratia marcescens and its investigation and control in a neonatal intensive care unit (NICU). During a three-month period, five infants were colonised or infected by a single strain of S. marcescens. A case-control study, culture surveys and pulse-field gel electrophoresis analysis implicated a bottle soap dispenser as a reservoir of S. marcescens (P=0.032). Infants with S. marcescens colonisation or infection were also more likely to have been exposed to a central or percutaneous venous catheter (P=0.05) and had had longer exposure to endotracheal intubation (P=0.05). Soap dispensers are used in many hospitals and may be an unrecognised source of nosocomial infections. This potential source of infection could be reduced by using 'airless' dispensers which have no air intake for the distribution of soap. Prompt intervention and strict adherence to alcoholic hand disinfection were the key factors that led to the successful control of this outbreak.  
  Call Number Serial 1655  
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Author Birch, L.L.; Marlin, D.W. file  url
  Title I don't like it; I never tried it: effects of exposure on two-year-old children's food preferences Type Journal Article
  Year 1982 Publication Appetite Abbreviated Journal Appetite  
  Volume 3 Issue 4 Pages 353-360  
  Keywords Age Factors; Child, Preschool; Feeding Behavior; *Food; *Food Preferences; Humans  
  Abstract The relationship between frequency of exposure to foods and preference for those foods was investigated in two experiments. Participants in both studies were two-year-old children. In Experiment 1, each of six children received 20, 15, 10, 5 or 2 exposures of five initially novel cheeses during a 26-day series of familiarization trials in which one pair of foods was presented per day. In Experiment 2, eight children received 20, 15, 10, 5 and 0 exposures to five initially novel fruits, following the same familiarization procedures, for 25 days. The particular food assigned to an exposure frequency was counterbalanced over subjects. Initial novelty was ascertained through food history information. Within ten days after the familiarization trials, children were given ten choice trials, comprising all possible pairs of the five foods. Thurstone scaling solutions were obtained for the series of choices: when the resulting scale values for the five stimuli were correlated with exposure frequency, values of r = 0·95, p < 0·02; r = 0·97, p < 0·01; and r = 0·94, p < 0·02 were obtained for the data of Experiments 1, 2, and the combined sample, respectively. A second analysis, employing subjects rather than stimuli as degrees of freedom, revealed that 13 of 14 subjects chose the more familiar stimulus in the sequence of ten choice trials at greater than the level expected by chance, providing evidence for effects within subjects as well as consistency across subjects. These results indicate that preference is an increasing function of exposure frequency. The data are consistent with the mere exposure hypothesis (Zajonc, 1968) as well as with the literature on the role of neophobia in food selection of animals other than man.

Subject Headings: Age Factors; Child, Preschool; Feeding Behavior; *Food; *Food Preferences; Humans

Keywords: I don't like it; I never tried it: effects of exposure on two-year-old children's food preferences
  Call Number Serial 2686  
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Author Culmsee, C.; Mattson, M.P. file  url
  Title p53 in neuronal apoptosis Type Journal Article
  Year 2005 Publication Biochemical and Biophysical Research Communications Abbreviated Journal Biochem Biophys Res Commun  
  Volume 331 Issue 3 Pages 761-777  
  Keywords Animals; Apoptosis/*physiology; Apoptosis Regulatory Proteins; DNA Damage; Gene Expression Regulation; Humans; Neurodegenerative Diseases/*physiopathology; Neurons/*cytology/*physiology; Nuclear Proteins/physiology; Proto-Oncogene Proteins/physiology; Proto-Oncogene Proteins c-bcl-2/physiology; Proto-Oncogene Proteins c-mdm2; Synapses/physiology; Transcriptional Activation; Tumor Suppressor Protein p53/*physiology; bcl-2-Associated X Protein  
  Abstract The tumor suppressor and transcription factor p53 is a key modulator of cellular stress responses, and activation of p53 can trigger apoptosis in many cell types including neurons. Apoptosis is a form of programmed cell death that occurs in neurons during development of the nervous system and may also be responsible for neuronal deaths that occur in neurological disorders such as stroke, and Alzheimer's and Parkinson's diseases. p53 production is rapidly increased in neurons in response to a range of insults including DNA damage, oxidative stress, metabolic compromise, and cellular calcium overload. Target genes induced by p53 in neurons include those encoding the pro-apoptotic proteins Bax and the BH3-only proteins PUMA and Noxa. In addition to such transcriptional control of the cell death machinery, p53 may more directly trigger apoptosis by acting at the level of mitochondria, a process that can occur in synapses (synaptic apoptosis). Preclinical data suggest that agents that inhibit p53 may be effective therapeutics for several neurodegenerative conditions.  
  Call Number Serial 2167  
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Author Tuk, M.A.; Zhang, K.; Sweldens, S. file  url
  Title The propagation of self-control: Self-control in one domain simultaneously improves self-control in other domains Type Journal Article
  Year 2015 Publication Journal of Experimental Psychology. General Abbreviated Journal J Exp Psychol Gen  
  Volume 144 Issue 3 Pages 639-654  
  Keywords Attention/physiology; Decision Making/physiology; *Ego; Emotions/physiology; Humans; *Inhibition (Psychology); *Self-Control  
  Abstract [Correction Notice: An Erratum for this article was reported in Vol 144(3) of Journal of Experimental Psychology: General (see record 2015-24174-008). The affiliations for co-authors Kuangjie Zhang and Steven Sweldens were incorrect. All versions of this article have been corrected.] A rich tradition in self-control research has documented the negative consequences of exerting self-control in 1 task for self-control performance in subsequent tasks. However, there is a dearth of research examining what happens when people exert self-control in multiple domains simultaneously. The current research aims to fill this gap. We integrate predictions from the most prominent models of self-control with recent neuropsychological insights in the human inhibition system to generate the novel hypothesis that exerting effortful self-control in 1 task can simultaneously improve self-control in completely unrelated domains. An internal meta-analysis on all 18 studies we conducted shows that exerting self-control in 1 domain (i.e., controlling attention, food consumption, emotions, or thoughts) simultaneously improves self-control in a range of other domains, as demonstrated by, for example, reduced unhealthy food consumption, better Stroop task performance, and less impulsive decision making. A subset of 9 studies demonstrates the crucial nature of task timing-when the same tasks are executed sequentially, our results suggest the emergence of an ego depletion effect. We provide conservative estimates of the self-control facilitation (d = |0.22|) as well as the ego depletion effect size (d = |0.17|) free of data selection and publication biases. These results (a) shed new light on self-control theories, (b) confirm recent claims that previous estimates of the ego depletion effect size were inflated due to publication bias, and (c) provide a blueprint for how to handle the power issues and associated file drawer problems commonly encountered in multistudy research projects.  
  Call Number Serial 1734  
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Author Pergamin-Hight, L.; Naim, R.; Bakermans-Kranenburg, M.J.; van IJzendoorn, M.H.; Bar-Haim, Y. file  url
  Title Content specificity of attention bias to threat in anxiety disorders: a meta-analysis Type Journal Article
  Year 2015 Publication Clinical Psychology Review Abbreviated Journal Clin Psychol Rev  
  Volume 35 Issue Pages 10-18  
  Keywords Anxiety Disorders/*psychology; *Attention; Humans; Anxiety; Attention; Attention bias modification; Threat  
  Abstract Despite the established evidence for threat-related attention bias in anxiety, the mechanisms underlying this bias remain unclear. One important unresolved question is whether disorder-congruent threats capture attention to a greater extent than do more general or disorder-incongruent threat stimuli. Evidence for attention bias specificity in anxiety would implicate involvement of previous learning and memory processes in threat-related attention bias, whereas lack of content specificity would point to perturbations in more generic attention processes. Enhanced clarity of mechanism could have clinical implications for the stimuli types used in Attention Bias Modification Treatments (ABMT). Content specificity of threat-related attention bias in anxiety and potential moderators of this effect were investigated. A systematic search identified 37 samples from 29 articles (N=866). Relevant data were extracted based on specific coding rules, and Cohen's d effect size was used to estimate bias specificity effects. The results indicate greater attention bias toward disorder-congruent relative to disorder-incongruent threat stimuli (d=0.28, p<0.0001). This effect was not moderated by age, type of anxiety disorder, visual attention tasks, or type of disorder-incongruent stimuli. No evidence of publication bias was observed. Implications for threat bias in anxiety and ABMT are discussed.  
  Call Number Serial 1729  
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