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Author Shankman, S.A.; Gorka, S.M. file  url
  Title Psychopathology research in the RDoC era: Unanswered questions and the importance of the psychophysiological unit of analysis Type Journal Article
  Year 2015 Publication International Journal of Psychophysiology : Official Journal of the International Organization of Psychophysiology Abbreviated Journal Int J Psychophysiol  
  Volume (down) 98 Issue 2 Pt 2 Pages 330-337  
  Keywords Humans; Mental Disorders/*physiopathology; Psychophysiology; *Research; Negative valence system; Positive valence system; Psychophysiology; Research Domain Criteria  
  Abstract The NIMH Research Domain Criteria (RDoC) initiative seeks to re-conceptualize psychopathology by identifying transdiagnostic constructs that reflect core mechanisms of psychopathology. Although the RDoC framework has been discussed in many prior papers, there are several methodological and conceptual points that have yet to be fully specified. For example, little discussion exists on the importance of distinguishing each construct's nomological network and linking it to risk for psychopathology. It has also been unclear the extent to which RDoC constructs (within and across systems) should relate to one another and how these associations may differ as a function of developmental period. These are important questions as we enter the RDoC era and psychophysiological measures represent an exciting tool to address these issues. In this paper, we discuss the currently un- (or under-)specified aspects of the RDoC initiative and highlight the advantages of the psychophysiological 'unit of analysis.' We also briefly review existing psychophysiological studies, within the positive and negative valence systems, that exemplify the RDoC approach and make recommendations for how future studies can help the field progress in this mission.  
  Call Number Serial 1832  
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Author Kostas, G. file  url
  Title Low-fat and delicious: can we break the taste barrier? Type Journal Article
  Year 1997 Publication Journal of the American Dietetic Association Abbreviated Journal J Am Diet Assoc  
  Volume (down) 97 Issue 7 Suppl Pages S88-92  
  Keywords *Cooking/methods/standards; Diet, Fat-Restricted/*standards; Humans; *Taste  
  Abstract No matter how healthy a food or recipe might be, if it does not taste good, people will not eat it. The professional and personal challenge is to find ways to cook favorite foods in a low-fat and delicious style to maintain health while enjoying foods without guilt. A number of strategies can be employed to reach that goal, including ingredient choices, low-fat product substitutes, cookware, cooking techniques, seasonings, basic cooking and recipe modifications, and the creation of new recipes.  
  Call Number Serial 515  
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Author Thongthae, N.; Payungporn, S.; Poovorawan, Y.; T-Thienprasert, N.P. file  url
  Title A rational study for identification of highly effective siRNAs against hepatitis B virus Type Journal Article
  Year 2014 Publication Experimental and Molecular Pathology Abbreviated Journal Exp Mol Pathol  
  Volume (down) 97 Issue 1 Pages 120-127  
  Keywords 2',5'-Oligoadenylate Synthetase/genetics; Algorithms; Base Sequence; Gene Expression Regulation; Hep G2 Cells/virology; Hepatitis B virus/*genetics; Humans; Luciferases/genetics/metabolism; Molecular Sequence Data; NF-kappa B/genetics; Promoter Regions, Genetic; RNA, Small Interfering/chemistry/*genetics; Regulatory Sequences, Nucleic Acid; STAT1 Transcription Factor/genetics; Thermodynamics; Effective siRNAs; Hbv Pre; Hepatitis B virus; RNA interference; siRNA predicting program  
  Abstract RNA interference (RNAi) is a powerful gene knockdown technique used for study gene function. It also potentially provides effective agents for inhibiting infectious and genetic diseases. Most of RNAi studies employ a single siRNA designing program and then require large-scale screening experiments to identify functional siRNAs. In this study, we demonstrate that an assembly of results generated from different siRNA designing programs could provide clusters of predicting sites that aided selection of potent siRNAs. Based on the clusters, three siRNA target sites were selected on a conserved RNA region of hepatitis B virus (HBV), known as HBV post-transcriptional regulatory element (HBV PRE) at nucleotide positions 1317-1337, 1357-1377 and 1644-1664. All three chosen siRNAs driven by H1 promoter were highly effective and could drastically decrease expression of HBV transcripts (core, surface and X) and surface protein without induction of interferon response and cell cytotoxicity in liver cancer cell line (HepG2). Based on prediction of secondary structures, the silencing effects of siRNAs were less effective against a loop sequence of the mRNA target with hairpin structure. In summary, we demonstrate an effectual approach for identification of functional siRNAs. Moreover, highly potent siRNAs identified here may serve as novel agents for development of nucleic acid-based HBV therapy.  
  Call Number Serial 1012  
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Author Chen, C.; Zhang, G.; Liu, X.C.; Ci, Y.; Huang, H.; Ma, J.; Chen, Y.; Guan, H. file  url
  Title Driver injury severity outcome analysis in rural interstate highway crashes: a two-level Bayesian logistic regression interpretation Type Journal Article
  Year 2016 Publication Accident; Analysis and Prevention Abbreviated Journal Accid Anal Prev  
  Volume (down) 97 Issue Pages 69-78  
  Keywords Accidents, Traffic/*statistics & numerical data; Adolescent; Adult; Automobile Driving/*statistics & numerical data; Bayes Theorem; China; Female; Humans; Logistic Models; Male; Middle Aged; Models, Theoretical; *Rural Population; Safety/*statistics & numerical data; Seat Belts/utilization; Bayesian inference; Driver injury severity; Hierarchical model; Rural interstate highway; Traffic crash  
  Abstract There is a high potential of severe injury outcomes in traffic crashes on rural interstate highways due to the significant amount of high speed traffic on these corridors. Hierarchical Bayesian models are capable of incorporating between-crash variance and within-crash correlations into traffic crash data analysis and are increasingly utilized in traffic crash severity analysis. This paper applies a hierarchical Bayesian logistic model to examine the significant factors at crash and vehicle/driver levels and their heterogeneous impacts on driver injury severity in rural interstate highway crashes. Analysis results indicate that the majority of the total variance is induced by the between-crash variance, showing the appropriateness of the utilized hierarchical modeling approach. Three crash-level variables and six vehicle/driver-level variables are found significant in predicting driver injury severities: road curve, maximum vehicle damage in a crash, number of vehicles in a crash, wet road surface, vehicle type, driver age, driver gender, driver seatbelt use and driver alcohol or drug involvement. Among these variables, road curve, functional and disabled vehicle damage in crash, single-vehicle crashes, female drivers, senior drivers, motorcycles and driver alcohol or drug involvement tend to increase the odds of drivers being incapably injured or killed in rural interstate crashes, while wet road surface, male drivers and driver seatbelt use are more likely to decrease the probability of severe driver injuries. The developed methodology and estimation results provide insightful understanding of the internal mechanism of rural interstate crashes and beneficial references for developing effective countermeasures for rural interstate crash prevention.  
  Call Number Serial 1784  
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Author McCoy, J.G.; Strecker, R.E. file  url
doi  openurl
  Title The cognitive cost of sleep lost Type Journal Article
  Year 2011 Publication Neurobiology of Learning and Memory Abbreviated Journal Neurobiol Learn Mem  
  Volume (down) 96 Issue 4 Pages 564-582  
  Keywords Attention/physiology; Brain/*physiopathology; Cognition/*physiology; Cognition Disorders/*etiology/physiopathology; Humans; Neuropsychological Tests; Sleep/*physiology; Sleep Deprivation/*complications/physiopathology  
  Abstract A substantial body of literature supports the intuitive notion that a good night's sleep can facilitate human cognitive performance the next day. Deficits in attention, learning & memory, emotional reactivity, and higher-order cognitive processes, such as executive function and decision making, have all been documented following sleep disruption in humans. Thus, whilst numerous clinical and experimental studies link human sleep disturbance to cognitive deficits, attempts to develop valid and reliable rodent models of these phenomena are fewer, and relatively more recent. This review focuses primarily on the cognitive impairments produced by sleep disruption in rodent models of several human patterns of sleep loss/sleep disturbance. Though not an exclusive list, this review will focus on four specific types of sleep disturbance: total sleep deprivation, experimental sleep fragmentation, selective REM sleep deprivation, and chronic sleep restriction. The use of rodent models can provide greater opportunities to understand the neurobiological changes underlying sleep loss induced cognitive impairments. Thus, this review concludes with a description of recent neurobiological findings concerning the neuroplastic changes and putative brain mechanisms that may underlie the cognitive deficits produced by sleep disturbances.  
  Call Number Serial 255  
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Author Ryan, M.K.; Haslam, S.A.; Hersby, M.D.; Bongiorno, R. file  url
doi  openurl
  Title Think crisis-think female: the glass cliff and contextual variation in the think manager-think male stereotype Type Journal Article
  Year 2011 Publication The Journal of Applied Psychology Abbreviated Journal J Appl Psychol  
  Volume (down) 96 Issue 3 Pages 470-484  
  Keywords Administrative Personnel/*psychology; Adult; Commerce/manpower/organization & administration; Data Collection; Efficiency, Organizational; Female; Gender Identity; Humans; Leadership; Male; Middle Aged; Sex Factors; *Stereotyping; Workplace/psychology; Young Adult  
  Abstract The “think manager-think male” (TMTM) association underlies many gender inequalities in the workplace. However, research into the “glass cliff” has demonstrated that the suitability of male and female managers varies as a function of company performance such that in times of poor performance people may “think female” (Ryan & Haslam, 2005, 2007). Three studies examined gender and managerial stereotypes in the context of companies that are doing well or doing badly. Study 1 reproduced TMTM associations for descriptions of managers of successful companies but demonstrated a reversal for managers of unsuccessful companies. Study 2 examined the prescriptive nature of these stereotypes. No TMTM relationship was found for ideal managers of successful companies, but ideal managers of unsuccessful companies were associated with the female stereotype. Study 3 suggested that women may be favored in times of poor performance, not because they are expected to improve the situation, but because they are seen to be good people managers and can take the blame for organizational failure. Together, the studies illustrate the importance of context as a moderator of the TMTM association. Practical and theoretical implications for gender discrimination in the workplace are discussed.  
  Call Number Serial 267  
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Author Edwards, R.G.; Donahue, R.P.; Baramki, T.A.; Jones, H.W.J. file  url
  Title Preliminary attempts to fertilize human oocytes matured in vitro Type Journal Article
  Year 1966 Publication American Journal of Obstetrics and Gynecology Abbreviated Journal Am J Obstet Gynecol  
  Volume (down) 96 Issue 2 Pages 192-200  
  Keywords Animals; Culture Techniques; Female; *Fertilization; Haplorhini; Humans; Male; Microscopy, Phase-Contrast; Ovum; Rabbits; Spermatozoa  
  Abstract Attempts were made to fertilize human oocytes after their maturation in culture. Initial attempts using washed spermatozoa showed that the great majority of eggs were unfertilized and that the spermatozoa failed to traverse the zona pellucida, probably because of lack of capacitation. Therefore, attempts were made to capacitate human spermatozoa by placing them in the reproductive tract of a rabbit, culturing them with pieces of human endosalpinx, taking them from cervical mucus, or transferring them with oocytes into the Fallopian tubes of estrous rabbits or hormonally primed monkeys. The incidence of fertilization remained very low after these treatment. Very few of the transferred human eggs were recovered from the monkeys.  
  Call Number Serial 1153  
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Author Fergusson, D.M.; Boden, J.M.; Horwood, L.J. file  url
  Title The developmental antecedents of illicit drug use: evidence from a 25-year longitudinal study Type Journal Article
  Year 2008 Publication Drug and Alcohol Dependence Abbreviated Journal Drug Alcohol Depend  
  Volume (down) 96 Issue 1-2 Pages 165-177  
  Keywords Adolescent; Adult; Age Factors; Child; Child Abuse/psychology/statistics & numerical data; Cohort Studies; Conduct Disorder/epidemiology/psychology; Humans; Life Change Events; Longitudinal Studies; Models, Statistical; New Zealand/epidemiology; Parents/psychology; Peer Group; Prospective Studies; Psychology, Adolescent/statistics & numerical data; Psychology, Child; Regression Analysis; Risk Factors; *Social Adjustment; Street Drugs/*adverse effects; Substance-Related Disorders/*diagnosis/epidemiology/psychology  
  Abstract BACKGROUND: The present study examined the developmental antecedents of illicit drug use and abuse/dependence. METHODS: A 25-year prospective longitudinal study of the health, development, and adjustment of a birth cohort of 1265 New Zealand children. Measures included assessments of adolescent and young adult illicit drug use and abuse/dependence; cannabis use to age 25; measures of parental adjustment; measures of exposure to childhood sexual abuse, physical abuse, and interparental violence; novelty-seeking; childhood and early adolescent adjustment and substance use; and affiliation with substance-using peers. RESULTS: Illicit drug use and abuse/dependence from ages 16 to 25 were significantly associated (all p values<.05) with a range of parental adjustment measures; exposure to abuse in childhood; individual factors; and measures of childhood and early adolescent adjustment. Analyses using repeated measures logistic regression models suggested that parental illicit drug use, gender, novelty-seeking, and childhood conduct disorder predicted later illicit drug use and abuse/dependence. Further analyses revealed that these pathways to illicit drug use and abuse/dependence were mediated via cannabis use, affiliation with substance-using peers, and alcohol use during ages 16-25. CONCLUSIONS: The current study suggested that the illicit drug use and abuse/dependence were associated with a range of early life circumstances and processes that put individuals at greater risk of illicit drug use and abuse/dependence. However, the use of cannabis in late adolescence and early adulthood emerged as the strongest risk factor for later involvement in other illicit drugs.  
  Call Number Serial 1682  
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Author Wilander, E.; Grimelius, L.; Lundqvist, G.; Skoog, V. file  url
  Title Polypeptide hormones in argentaffin and argyrophil gastroduodenal endocrine tumors Type Journal Article
  Year 1979 Publication The American Journal of Pathology Abbreviated Journal Am J Pathol  
  Volume (down) 96 Issue 2 Pages 519-530  
  Keywords Adrenocorticotropic Hormone/analysis; Adult; Aged; Duodenal Neoplasms/*metabolism/pathology; Endocrine System Diseases/*metabolism/pathology; Female; Gastrins/analysis; Glucagon-Like Peptides/analysis; Hormones/*analysis; Humans; Male; Middle Aged; Pancreatic Polypeptide/analysis; Stomach Neoplasms/*metabolism/pathology; Substance P/*analysis  
  Abstract The morphology and histochemistry of gastroduodenal endocrine tumors from 16 patients were studied. All patients underwent operation, in most cases with a preoperative diagnosis of nonendocrine tumor, ulcer, o polyp(s). The argentaffin reaction was positive in three tumors, and the Hellerstrom--Hellman argyrophil reaction was positive in four tumors. All tumors reacted positively to the Grimelius argyrophil stain, and 13 were positive with the Sevier--Munger argyrophil stain. Gastrin immunoreactivity was found in eight tumors, and substance-P immunoreactivity in seven tumors. No enteroglucagon, adrenal cortex hormone, or pancreatic polypeptide was observed in any of the tumors. Three patients with Sevier--Munger-positive gastric tumors had concurrent pernicious anemia, and 2 patients with gastrin-immunoreactive tumors had acute or chronic gastroduodenal ulceration. The results indicate that the gastroduodenal endocrine tumor as a rule gives no endocrine symptoms and that the tumor type is an unexpected finding at operation. The tumors may contain gastrin, substance P, somatostatin, and serotonin and tend to be multihormonal.  
  Call Number Serial 1760  
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Author Spellberg, B.; Shlaes, D. file  url
  Title Prioritized current unmet needs for antibacterial therapies Type Journal Article
  Year 2014 Publication Clinical Pharmacology and Therapeutics Abbreviated Journal Clin Pharmacol Ther  
  Volume (down) 96 Issue 2 Pages 151-153  
  Keywords Animals; Anti-Bacterial Agents/pharmacology/*therapeutic use; Bacterial Infections/drug therapy/epidemiology; *Drug Design; Drug Resistance, Multiple, Bacterial/*drug effects/physiology; Health Priorities/*trends; Health Services Needs and Demand/*trends; Humans  
  Abstract As a result of declining new antibacterial approvals and rising antibiotic resistance, society clearly needs new treatments for bacterial infections. Specific areas of unmet need evolve over time owing to changes in resistance patterns and treatment strategies. Our goal here is to describe and prioritize the current areas of greatest unmet need for new antibacterial development based on an understanding of the most serious treatment challenges facing patients and their providers today.  
  Call Number Serial 1891  
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