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Author (up) Guatteo, E.; Cucchiaroni, M.L.; Mercuri, N.B. file  url
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  Title Substantia nigra control of basal ganglia nuclei Type Journal Article
  Year 2009 Publication Journal of Neural Transmission. Supplementum Abbreviated Journal J Neural Transm Suppl  
  Volume Issue 73 Pages 91-101  
  Keywords Animals; Basal Ganglia/*physiology; Dopamine/metabolism/pharmacology; Humans; Membrane Potentials/physiology; Nerve Net/physiology; Neural Pathways/physiology; Neurons/drug effects/physiology; Parkinson Disease/pathology; Substantia Nigra/*cytology/*physiology  
  Abstract The substantia nigra, located in the ventral mesencephalon, is one of the five nuclei that constitute the basal ganglia circuit, which controls voluntary movements. It is divided into the pars compacta and the pars reticulata, which mainly contain dopaminergic and GABAergic cells respectively. Here we overview the electrophysiological properties of these substantia nigra neurons in the pars compacta and reticulata, together with their synaptic connections, and discuss the functional effects of dopaminergic and GABAergic inputs within the basal ganglia. We also examine the phenomenon that when a deficiency of dopamine (DA) occurs (e.g. in Parkinson's disease), there is an aberrant synaptic plasticity in the basal ganglia. Moreover, we point out that the appearance of an altered pattern of neuronal firing (beta-oscillations) and synchrony among neurons in the subthalamic nucleus, the internal globus pallidus, and the substantia nigra pars reticulata has been related to motor symptoms and possibly, persistent degeneration of DA-containing neurons. Finally, we believe that, based on pathophysiological data, new and significant targets for therapeutic intervention can be identified and tested.  
  Call Number Serial 346  
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