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Author (up) Andersen, S.B.; Karstoft, K.-I.; Bertelsen, M.; Madsen, T. file  url
openurl 
  Title Latent trajectories of trauma symptoms and resilience: the 3-year longitudinal prospective USPER study of Danish veterans deployed in Afghanistan Type Journal Article
  Year 2014 Publication The Journal of Clinical Psychiatry Abbreviated Journal J Clin Psychiatry  
  Volume 75 Issue 9 Pages 1001-1008  
  Keywords Adult; Afghan Campaign 2001-; Denmark/epidemiology; Female; Humans; Male; Military Personnel/psychology/statistics & numerical data; Prospective Studies; Psychiatric Status Rating Scales; *Resilience, Psychological; Risk Factors; Stress Disorders, Post-Traumatic/epidemiology/*etiology/psychology; Time Factors; Veterans/*psychology/statistics & numerical data; Young Adult  
  Abstract OBJECTIVE: To identify trajectories of posttraumatic stress disorder (PTSD) symptoms from before to 2.5 years after deployment and to assess risk factors for symptom fluctuations and late-onset PTSD. METHOD: 743 soldiers deployed to Afghanistan in 2009 were assessed for PTSD symptoms using the PTSD Checklist (PCL) at 6 occasions from predeployment to 2.5 years postdeployment (study sample = 561). Predeployment vulnerabilities and deployment and postdeployment stressors were also assessed. RESULTS: Six trajectories were identified: a resilient trajectory with low symptom levels across all assessments (78.1%) and 5 trajectories showing symptom fluctuations. These included a trajectory of late onset (5.7%), independently predicted by earlier emotional problems (OR = 5.59; 95% CI, 1.57-19.89) and predeployment and postdeployment traumas (OR = 1.10; 95% CI, 1.04-1.17 and OR = 1.13; 95% CI, 1.00-1.26). Two trajectories of symptom fluctuations in the low-to-moderate range (7.5% and 4.1%); a trajectory of symptom relief during deployment, but with a drastic increase at the final assessments (2.0%); and a trajectory with mild symptom increase during deployment followed by relief at return (2.7%) were also found. Symptom fluctuation was predicted independently by predeployment risk factors (depression [OR = 1.27; 95% CI, 1.16-1.39], neuroticism [OR = 1.10; 95% CI, 1.00-1.21], and earlier traumas [OR = 1.09; 95% CI, 1.03-1.16]) and deployment-related stressors (danger/injury exposure [OR = 1.20; 95% CI, 1.04-1.40]), but not by postdeployment stressors. DISCUSSION: The results confirm earlier findings of stress response heterogeneity following military deployment and highlight the impact of predeployment, perideployment, and postdeployment risk factors in predicting PTSD symptomatology and late-onset PTSD symptoms.  
  Call Number Serial 1304  
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Author (up) Block, J.H.; Block, J.; Gjerde, P.F. file  url
openurl 
  Title The personality of children prior to divorce: a prospective study Type Journal Article
  Year 1986 Publication Child Development Abbreviated Journal Child Dev  
  Volume 57 Issue 4 Pages 827-840  
  Keywords Adolescent; Child; Child Development; Child, Preschool; *Divorce; Female; Humans; Intelligence; Male; *Personality; Personality Development; Prospective Studies; Sex Factors; Stress, Psychological/psychology  
  Abstract In a longitudinal study, the personalities of children from intact families at ages 3, 4, and 7 were reliably assessed by independent sets of raters using Q-items reflecting important psychological characteristics of children. A number of these families subsequently experienced divorce. The behavior of boys was found, as early as 11 years prior to parental separation or formal dissolution of marriage, to be consistently affected by what can be presumed to be predivorce familial stress. The behavior of boys from subsequently divorcing families was characterized by undercontrol of impulse, aggression, and excessive energy prior to parental divorce. The behavior of girls from subsequently divorcing families was found to be notably less affected by the stresses in families prior to parental divorce. The prospective relations afforded by the longitudinal analyses suggest that the behavior of conflicting, inaccessible parents during the preseparation period may have serious consequences for personality development, especially for boys. Hence, some characteristics of children commonly seen to be a consequence of divorce may be present prior to marital dissolution.  
  Call Number Serial 280  
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Author (up) Boeuf-Cazou, O.; Bongue, B.; Ansiau, D.; Marquie, J.-C.; Lapeyre-Mestre, M. file  url
openurl 
  Title Impact of long-term benzodiazepine use on cognitive functioning in young adults: the VISAT cohort Type Journal Article
  Year 2011 Publication European Journal of Clinical Pharmacology Abbreviated Journal Eur J Clin Pharmacol  
  Volume 67 Issue 10 Pages 1045-1052  
  Keywords Adult; Aptitude/drug effects; Benzodiazepines/*administration & dosage/adverse effects; Cognition/*drug effects; Cohort Studies; Female; Follow-Up Studies; Humans; Male; Memory, Long-Term/drug effects; Mental Recall/drug effects; Middle Aged; Neuropsychological Tests; Prospective Studies; Questionnaires; Sex Factors  
  Abstract PURPOSE: Results from a number of studies have suggested a relationship between cognitive alteration and benzodiazepine use in the elderly. The aim of this study was to determine the impact of benzodiazepine use on cognitive functions in a young adult population. METHODS: This study included 1,019 French salaried workers from the VISAT (Aging, Health and Work) cohort whose objective was to determine the long-term impact of working conditions on health and aging. Data were collected during interviews by occupational physicians in 1996, 2001 and 2006. Cognitive function was assessed using five cognitive tests (immediate free recall test, delayed free recall test, recognition test, Digit Symbol Substitution Subtest and visual search speed test). Cognitive scores obtained after a 10-year follow-up were investigated among three categories of benzodiazepine users, namely, non-users, occasional users and long-term users, using analysis of covariance models adjusted for several potential confounders in men and women separately. RESULTS: In the course of the 10 year-follow-up, 3.9% of subjects were defined as occasional users of benzodiazepine and 7.5% as long-term users. The analysis revealed a significant alteration of long-term memory in women whereas there was no significant association in men. CONCLUSIONS: Long-term use of benzodiazepine leads to specific impairment in long-term memory only in women.  
  Call Number Serial 265  
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Author (up) Bryant, R.A.; O'Donnell, M.L.; Creamer, M.; McFarlane, A.C.; Silove, D. file  url
openurl 
  Title A multisite analysis of the fluctuating course of posttraumatic stress disorder Type Journal Article
  Year 2013 Publication JAMA Psychiatry Abbreviated Journal JAMA Psychiatry  
  Volume 70 Issue 8 Pages 839-846  
  Keywords Adolescent; Adult; Aged; Australia/epidemiology; Brain Injuries/diagnosis/epidemiology/*psychology; *Disease Progression; Female; Humans; Injury Severity Score; Male; Middle Aged; Prospective Studies; Severity of Illness Index; Stress Disorders, Post-Traumatic/diagnosis/epidemiology/*psychology; Stress, Psychological/complications/diagnosis/epidemiology; Time Factors; Young Adult  
  Abstract IMPORTANCE: Delayed-onset posttraumatic stress disorder (PTSD) accounts for approximately 25% of PTSD cases. Current models do not adequately explain the delayed increases in PTSD symptoms after trauma exposure. OBJECTIVE: To test the roles of initial psychiatric reactions, mild traumatic brain injury (MTBI), and ongoing stressors on delayed-onset PTSD. DESIGN, SETTING, AND PARTICIPANTS: In this prospective cohort study, patients were selected from recent admissions to 4 major trauma hospitals across Australia. A total of 1084 traumatically injured patients were assessed during hospital admission from April 1, 2004, through February 28, 2006, and 785 (72.4%) were followed up at 3, 12, and 24 months after injury. MAIN OUTCOME AND MEASURE: Severity of PTSD was determined at each assessment with the Clinician-Administered PTSD Scale. RESULTS: Of those who met PTSD criteria at 24 months, 44.1% reported no PTSD at 3 months and 55.9% had subsyndromal or full PTSD. In those who displayed subsyndromal or full PTSD at 3 months, PTSD severity at 24 months was predicted by prior psychiatric disorder, initial PTSD symptom severity, and type of injury. In those who displayed no PTSD at 3 months, PTSD severity at 24 months was predicted by initial PTSD symptom severity, MTBI, length of hospitalization, and the number of stressful events experienced between 3 and 24 months. CONCLUSIONS AND RELEVANCE: These data highlight the complex trajectories of PTSD symptoms over time. This study also points to the roles of ongoing stress and MTBI in delayed cases of PTSD and suggests the potential of ongoing stress to compound initial stress reactions and lead to a delayed increase in PTSD symptom severity. This study also provides initial evidence that MTBI increases the risk of delayed PTSD symptoms, particularly in those with no acute symptoms.  
  Call Number Serial 1306  
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Author (up) Buckland, G.; Gonzalez, C.A.; Agudo, A.; Vilardell, M.; Berenguer, A.; Amiano, P.; Ardanaz, E.; Arriola, L.; Barricarte, A.; Basterretxea, M.; Chirlaque, M.D.; Cirera, L.; Dorronsoro, M.; Egues, N.; Huerta, J.M.; Larranaga, N.; Marin, P.; Martinez, C.; Molina, E.; Navarro, C.; Quiros, J.R.; Rodriguez, L.; Sanchez, M.-J.; Tormo, M.-J.; Moreno-Iribas, C. file  url
doi  openurl
  Title Adherence to the Mediterranean diet and risk of coronary heart disease in the Spanish EPIC Cohort Study Type Journal Article
  Year 2009 Publication American Journal of Epidemiology Abbreviated Journal Am J Epidemiol  
  Volume 170 Issue 12 Pages 1518-1529  
  Keywords Adult; Aged; Body Weights and Measures; Coronary Disease/*epidemiology; *Diet, Mediterranean; Female; Health Behavior; Humans; Male; Middle Aged; Prospective Studies; Risk Factors; Sex Factors; Socioeconomic Factors; Spain/epidemiology  
  Abstract No known cohort study has investigated whether the Mediterranean diet can reduce incident coronary heart disease (CHD) events in a Mediterranean population. This study examined the relation between Mediterranean diet adherence and risk of incident CHD events in the 5 Spanish centers of the European Prospective Investigation into Cancer and Nutrition. Analysis included 41,078 participants aged 29-69 years, recruited in 1992-1996 and followed up until December 2004 (mean follow-up:10.4 years). Confirmed incident fatal and nonfatal CHD events were analyzed according to Mediterranean diet adherence, measured by using an 18-unit relative Mediterranean diet score. A total of 609 participants (79% male) had a fatal or nonfatal confirmed acute myocardial infarction (n = 468) or unstable angina requiring revascularization (n = 141). After stratification by center and age and adjustment for recognized CHD risk factors, high compared with low relative Mediterranean diet score was associated with a significant reduction in CHD risk (hazard ratio = 0.60, 95% confidence interval: 0.47, 0.77). A 1-unit increase in relative Mediterranean diet score was associated with a 6% reduced risk of CHD (95% confidence interval: 0.91, 0.97), with similar risk reductions by sex. Mediterranean diet adherence was associated with a significantly reduced CHD risk in this Mediterranean country, supporting its role in primary prevention of CHD in healthy populations.  
  Call Number Serial 135  
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Author (up) Clayton, R.R.; Cattarello, A.M.; Johnstone, B.M. file  url
openurl 
  Title The effectiveness of Drug Abuse Resistance Education (project DARE): 5-year follow-up results Type Journal Article
  Year 1996 Publication Preventive Medicine Abbreviated Journal Prev Med  
  Volume 25 Issue 3 Pages 307-318  
  Keywords Child; Curriculum; Effect Modifier, Epidemiologic; Female; Health Education/*methods; Health Knowledge, Attitudes, Practice; Humans; Kentucky; Male; Models, Statistical; Peer Group; Program Evaluation; Prospective Studies; Regression Analysis; *School Health Services; Substance-Related Disorders/*prevention & control/psychology  
  Abstract BACKGROUND: This article reports the results of a 5-year, longitudinal evaluation of the effectiveness of Drug Abuse Resistance Education (DARE), a school-based primary drug prevention curriculum designed for introduction during the last year of elementary education. DARE is the most widely disseminated school-based prevention curriculum in the United States. METHOD: Twenty-three elementary schools were randomly assigned to receive DARE and 8 were designated comparison schools. Students in the DARE schools received 16 weeks of protocol-driven instruction and students in the comparison schools received a drug education unit as part of the health curriculum. All students were pretested during the 6th grade prior to delivery of the programs, posttested shortly after completion, and resurveyed each subsequent year through the 10th grade. Three-stage mixed effects regression models were used to analyze these data. RESULTS: No significant differences were observed between intervention and comparison schools with respect to cigarette, alcohol, or marijuana use during the 7th grade, approximately 1 year after completion of the program, or over the full 5-year measurement interval. Significant intervention effects in the hypothesized direction were observed during the 7th grade for measures of students' general and specific attitudes toward drugs, the capability to resist peer pressure, and estimated level of drug use by peers. Over the full measurement interval, however, average trajectories of change for these outcomes were similar in the intervention and comparison conditions. CONCLUSIONS: The findings of this 5-year prospective study are largely consonant with the results obtained from prior short-term evaluations of the DARE curriculum, which have reported limited effects of the program upon drug use, greater efficacy with respect to attitudes, social skills, and knowledge, but a general tendency for curriculum effects to decay over time. The results of this study underscore the need for more robust prevention programming targeted specifically at risk factors, the inclusion of booster sessions to sustain positive effects, and greater attention to interrelationships between developmental processes in adolescent substance use, individual level characteristics, and social context.  
  Call Number Serial 1562  
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Author (up) Cohen, J.F.W.; Jahn, J.L.; Richardson, S.; Cluggish, S.A.; Parker, E.; Rimm, E.B. file  url
openurl 
  Title Amount of Time to Eat Lunch Is Associated with Children's Selection and Consumption of School Meal Entree, Fruits, Vegetables, and Milk Type Journal Article
  Year 2016 Publication Journal of the Academy of Nutrition and Dietetics Abbreviated Journal J Acad Nutr Diet  
  Volume 116 Issue 1 Pages 123-128  
  Keywords Animals; Child; Diet; *Eating; Ethnic Groups; Female; *Food Preferences; *Food Services; Fruit; Humans; *Lunch; Male; Milk; Prospective Studies; *Schools; Students; Time Factors; Vegetables; Fruit intake; Lunch period length; Milk intake; School lunch; Vegetable intake  
  Abstract BACKGROUND: There are currently no national standards for school lunch period length and little is known about the association between the amount of time students have to eat and school food selection and consumption. OBJECTIVE: Our aim was to examine plate-waste measurements from students in the control arm of the Modifying Eating and Lifestyles at School study (2011 to 2012 school year) to determine the association between amount of time to eat and school meal selection and consumption. DESIGN: We used a prospective study design using up to six repeated measures among students during the school year. PARTICIPANTS/SETTING: One thousand and one students in grades 3 to 8 attending six participating elementary and middle schools in an urban, low-income school district where lunch period lengths varied from 20 to 30 minutes were included. MAIN OUTCOME MEASURES: School food selection and consumption were collected using plate-waste methodology. STATISTICAL ANALYSES PERFORMED: Logistic regression and mixed-model analysis of variance was used to examine food selection and consumption. RESULTS: Compared with meal-component selection when students had at least 25 minutes to eat, students were significantly less likely to select a fruit (44% vs 57%; P<0.0001) when they had <20 minutes to eat. There were no significant differences in entree, milk, or vegetable selections. Among those who selected a meal component, students with <20 minutes to eat consumed 13% less of their entree (P<0.0001), 10% less of their milk (P<0.0001), and 12% less of their vegetable (P<0.0001) compared with students who had at least 25 minutes to eat. CONCLUSIONS: During the school year, a substantial number of students had insufficient time to eat, which was associated with significantly decreased entree, milk, and vegetable consumption compared with students who had more time to eat. School policies that encourage lunches with at least 25 minutes of seated time might reduce food waste and improve dietary intake.  
  Call Number Serial 1256  
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Author (up) Fergusson, D.M.; Boden, J.M.; Horwood, L.J. file  url
openurl 
  Title The developmental antecedents of illicit drug use: evidence from a 25-year longitudinal study Type Journal Article
  Year 2008 Publication Drug and Alcohol Dependence Abbreviated Journal Drug Alcohol Depend  
  Volume 96 Issue 1-2 Pages 165-177  
  Keywords Adolescent; Adult; Age Factors; Child; Child Abuse/psychology/statistics & numerical data; Cohort Studies; Conduct Disorder/epidemiology/psychology; Humans; Life Change Events; Longitudinal Studies; Models, Statistical; New Zealand/epidemiology; Parents/psychology; Peer Group; Prospective Studies; Psychology, Adolescent/statistics & numerical data; Psychology, Child; Regression Analysis; Risk Factors; *Social Adjustment; Street Drugs/*adverse effects; Substance-Related Disorders/*diagnosis/epidemiology/psychology  
  Abstract BACKGROUND: The present study examined the developmental antecedents of illicit drug use and abuse/dependence. METHODS: A 25-year prospective longitudinal study of the health, development, and adjustment of a birth cohort of 1265 New Zealand children. Measures included assessments of adolescent and young adult illicit drug use and abuse/dependence; cannabis use to age 25; measures of parental adjustment; measures of exposure to childhood sexual abuse, physical abuse, and interparental violence; novelty-seeking; childhood and early adolescent adjustment and substance use; and affiliation with substance-using peers. RESULTS: Illicit drug use and abuse/dependence from ages 16 to 25 were significantly associated (all p values<.05) with a range of parental adjustment measures; exposure to abuse in childhood; individual factors; and measures of childhood and early adolescent adjustment. Analyses using repeated measures logistic regression models suggested that parental illicit drug use, gender, novelty-seeking, and childhood conduct disorder predicted later illicit drug use and abuse/dependence. Further analyses revealed that these pathways to illicit drug use and abuse/dependence were mediated via cannabis use, affiliation with substance-using peers, and alcohol use during ages 16-25. CONCLUSIONS: The current study suggested that the illicit drug use and abuse/dependence were associated with a range of early life circumstances and processes that put individuals at greater risk of illicit drug use and abuse/dependence. However, the use of cannabis in late adolescence and early adulthood emerged as the strongest risk factor for later involvement in other illicit drugs.  
  Call Number Serial 1682  
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Author (up) Henzl, M.R.; Corson, S.L.; Moghissi, K.; Buttram, V.C.; Berqvist, C.; Jacobson, J. file  url
openurl 
  Title Administration of nasal nafarelin as compared with oral danazol for endometriosis. Type Journal Article
  Year 1988 Publication The New England Journal of Medicine Abbreviated Journal N Engl J Med  
  Volume 318 Issue 8 Pages 485-489  
  Keywords Administration, Intranasal; Administration, Oral; Adolescent; Adult; Clinical Trials as Topic; Danazol/administration & dosage/therapeutic use; Double-Blind Method; Endometriosis/*drug therapy; Estradiol/blood; Female; Gonadotropin-Releasing Hormone/administration & dosage/adverse effects/*analogs & derivatives; Humans; Middle Aged; Nafarelin; Pregnancy/drug effects; Progesterone/blood; Prospective Studies; Uterine Neoplasms/*drug therapy  
  Abstract Treatment with nafarelin, a gonadotropin-releasing hormone agonist, reversibly inhibits ovarian function and induces hypoestrogenemia. To determine the efficacy of such hormonal manipulation in the treatment of endometriosis, we randomly assigned 213 patients with laparoscopically confirmed endometriosis to receive, for six months, either nafarelin by nasal spray (400 or 800 micrograms per day) or oral danazol (800 mg per day). Placebo nasal spray and placebo tablets were used to double blind the study. Pretreatment and post-treatment laparoscopies were compared by means of the American Fertility Society's scoring system. More than 80 percent of the patients in each treatment group had a reduction in the extent of disease as assessed by laparoscopy. The mean laparoscopic scores decreased from 21.9 to 12.6 with 800 micrograms of nafarelin, from 20.4 to 11.7 with 400 micrograms of nafarelin, and from 18.4 to 10.5 with danazol (P = 0.0001 within each group; there were no statistically significant differences between the groups). The percentage of women with severely painful symptoms of endometriosis decreased from about 40 percent to 5 to 10 percent, whereas the percentage with no or minimal discomfort rose from 25 to 70 percent. Of the 149 patients who tried to become pregnant, 58 (39 percent) succeeded after the completion of treatment; similar rates of pregnancy applied to the three treatment groups. Danazol use decreased high-density lipoprotein levels and increased low-density lipoprotein levels. These changes were not observed in nafarelin users, but a higher percentage of them reported hot flashes and decreased libido. We conclude that nafarelin is an effective agent for treating endometriosis and has few side effects other than hypoestrogenism.  
  Call Number Serial 1028  
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Author (up) Hijazi, Z.; Oldgren, J.; Andersson, U.; Connolly, S.J.; Ezekowitz, M.D.; Hohnloser, S.H.; Reilly, P.A.; Siegbahn, A.; Yusuf, S.; Wallentin, L. file  url
openurl 
  Title Importance of persistent elevation of cardiac biomarkers in atrial fibrillation: a RE-LY substudy Type Journal Article
  Year 2014 Publication Heart (British Cardiac Society) Abbreviated Journal Heart  
  Volume 100 Issue 15 Pages 1193-1200  
  Keywords Atrial Fibrillation/*blood/complications/physiopathology; Biological Markers/blood; Follow-Up Studies; Humans; Incidence; Myocardium/*metabolism; Natriuretic Peptide, Brain/*blood; Peptide Fragments/*blood; Predictive Value of Tests; Prognosis; Prospective Studies; Stroke/blood/epidemiology/*etiology; Survival Rate/trends; Sweden/epidemiology; Troponin T/*blood  
  Abstract OBJECTIVES: To evaluate the prognostic importance of transient or persistent elevations of cardiac troponin-I (cTnI) and N-terminal-B-type natriuretic peptide (NT-proBNP) in atrial fibrillation (AF). METHODS: Plasma samples were obtained at randomisation and after 3 months in 2514 patients with AF in the RE-LY trial; median follow-up was 2.0 years. Patients were grouped based on levels at the two time points according to detectable cTnI levels (>/=0.01 microg/L) or NT-proBNP levels above median (>/=778 ng/L). These groups were related to occurrence of stroke or cardiovascular events evaluated with Cox models adjusting for established risk factors. RESULTS: The proportion of patients with detectable cTnI levels at both time points was 48.5%, at one time point 28.5% and at neither time point 21.0%. Patients with detectable cTnI at both time points had substantially higher rates of stroke compared with those with transient elevations and those with no elevation at either time point (p<0.005, effect of cTnI). Persistent elevation of either or both cardiac biomarkers at baseline and 3 months was associated with a higher risk for cardiovascular events and mortality (p<0.0001). Prognostic prediction improved most with the use of repeated measurements of both cardiac biomarkers simultaneously (p<0.05) and achieved C-statistic 0.644 for stroke compared with 0.611 for CHADS2-score. CONCLUSIONS: Persistent elevation of troponin and NT-proBNP indicates a worse prognosis than transient elevations or no elevations of either marker. Prognostication of stroke, death and thromboembolic events is improved by the use of repeated determinations of cardiac biomarkers. TRIAL REGISTRATION NUMBER: http://www.clinicaltrials.gov, NCT00262600.  
  Call Number Serial 1006  
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