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Author (up) Baron-Cohen, S.; Richler, J.; Bisarya, D.; Gurunathan, N.; Wheelwright, S. file  url
  Title The systemizing quotient: an investigation of adults with Asperger syndrome or high-functioning autism, and normal sex differences Type Journal Article
  Year 2003 Publication Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences Abbreviated Journal Philos Trans R Soc Lond B Biol Sci  
  Volume 358 Issue 1430 Pages 361-374  
  Keywords Adult; Asperger Syndrome/*diagnosis/*psychology; Autistic Disorder/diagnosis/psychology; Empathy; Female; Humans; Male; *Psychological Tests; Psychological Theory; *Questionnaires; *Sex Characteristics  
  Abstract Systemizing is the drive to analyse systems or construct systems. A recent model of psychological sex differences suggests that this is a major dimension in which the sexes differ, with males being more drawn to systemize than females. Currently, there are no self-report measures to assess this important dimension. A second major dimension of sex differences is empathizing (the drive to identify mental states and respond to these with an appropriate emotion). Previous studies find females score higher on empathy measures. We report a new self-report questionnaire, the Systemizing Quotient (SQ), for use with adults of normal intelligence. It contains 40 systemizing items and 20 control items. On each systemizing item, a person can score 2, 1 or 0, so the SQ has a maximum score of 80 and a minimum of zero. In Study 1, we measured the SQ of n = 278 adults (114 males, 164 females) from a general population, to test for predicted sex differences (male superiority) in systemizing. All subjects were also given the Empathy Quotient (EQ) to test if previous reports of female superiority would be replicated. In Study 2 we employed the SQ and the EQ with n = 47 adults (33 males, 14 females) with Asperger syndrome (AS) or high-functioning autism (HFA), who are predicted to be either normal or superior at systemizing, but impaired at empathizing. Their scores were compared with n = 47 matched adults from the general population in Study 1. In Study 1, as predicted, normal adult males scored significantly higher than females on the SQ and significantly lower on the EQ. In Study 2, again as predicted, adults with AS/HFA scored significantly higher on the SQ than matched controls, and significantly lower on the EQ than matched controls. The SQ reveals both a sex difference in systemizing in the general population and an unusually strong drive to systemize in AS/HFA. These results are discussed in relation to two linked theories: the 'empathizing-systemizing' (E-S) theory of sex differences and the extreme male brain (EMB) theory of autism.  
  Call Number Serial 946  
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Author (up) Boeuf-Cazou, O.; Bongue, B.; Ansiau, D.; Marquie, J.-C.; Lapeyre-Mestre, M. file  url
  Title Impact of long-term benzodiazepine use on cognitive functioning in young adults: the VISAT cohort Type Journal Article
  Year 2011 Publication European Journal of Clinical Pharmacology Abbreviated Journal Eur J Clin Pharmacol  
  Volume 67 Issue 10 Pages 1045-1052  
  Keywords Adult; Aptitude/drug effects; Benzodiazepines/*administration & dosage/adverse effects; Cognition/*drug effects; Cohort Studies; Female; Follow-Up Studies; Humans; Male; Memory, Long-Term/drug effects; Mental Recall/drug effects; Middle Aged; Neuropsychological Tests; Prospective Studies; Questionnaires; Sex Factors  
  Abstract PURPOSE: Results from a number of studies have suggested a relationship between cognitive alteration and benzodiazepine use in the elderly. The aim of this study was to determine the impact of benzodiazepine use on cognitive functions in a young adult population. METHODS: This study included 1,019 French salaried workers from the VISAT (Aging, Health and Work) cohort whose objective was to determine the long-term impact of working conditions on health and aging. Data were collected during interviews by occupational physicians in 1996, 2001 and 2006. Cognitive function was assessed using five cognitive tests (immediate free recall test, delayed free recall test, recognition test, Digit Symbol Substitution Subtest and visual search speed test). Cognitive scores obtained after a 10-year follow-up were investigated among three categories of benzodiazepine users, namely, non-users, occasional users and long-term users, using analysis of covariance models adjusted for several potential confounders in men and women separately. RESULTS: In the course of the 10 year-follow-up, 3.9% of subjects were defined as occasional users of benzodiazepine and 7.5% as long-term users. The analysis revealed a significant alteration of long-term memory in women whereas there was no significant association in men. CONCLUSIONS: Long-term use of benzodiazepine leads to specific impairment in long-term memory only in women.  
  Call Number Serial 265  
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Author (up) Coccaro, E.F.; Bergeman, C.S.; McClearn, G.E. file  url
  Title Heritability of irritable impulsiveness: a study of twins reared together and apart Type Journal Article
  Year 1993 Publication Psychiatry Research Abbreviated Journal Psychiatry Res  
  Volume 48 Issue 3 Pages 229-242  
  Keywords Adult; Aged; Aggression; Environment; Female; Hostility; Humans; Impulsive Behavior/*genetics; Male; Middle Aged; Personality Disorders/diagnosis/*genetics; Personality Inventory; Questionnaires; Receptors, Serotonin/genetics/physiology; Twins/*genetics  
  Abstract The heritability of self-reported personality traits related to impulsiveness, irritability, and the inhibition of assertive or aggressive behavior was examined in up to 500 healthy monozygotic and dizygotic twin pairs raised together or apart. Two factors related to “(lack of) assertiveness/aggression” (Factor I) and “impulsive irritability” (Factor II) were examined using traditional and model-fitting procedures. Results of model-fitting procedures were consistent with a genetic, but not a shared environmental, influence for both factors. Further analysis suggested a nonadditive genetic influence for Factor II and an additive influence for Factor I. Bivariate model-fitting analyses suggest that self-reported “irritable impulsiveness” and “(lack of) assertiveness/aggressiveness” show substantial, though different, genetic influences.  
  Call Number Serial 315  
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Author (up) Davis, J. file  url
  Title The effect of qualifying language on perceptions of drug appeal, drug experience, and estimates of side-effect incidence in DTC advertising Type Journal Article
  Year 2007 Publication Journal of Health Communication Abbreviated Journal J Health Commun  
  Volume 12 Issue 7 Pages 607-622  
  Keywords Adult; Advertising as Topic/*standards; Analysis of Variance; Drug Industry/*standards; Drug-Related Side Effects and Adverse Reactions; Female; Humans; Likelihood Functions; Male; Patient Satisfaction/*statistics & numerical data; *Persuasive Communication; *Pharmaceutical Preparations; Risk Assessment/*standards; Surveys and Questionnaires; *Terminology as Topic; United States; United States Food and Drug Administration  
  Abstract This study examined how the use of qualifying language in direct-to-consumer (DTC) pharmaceutical advertising affects consumers' perceptions of drug appeal, anticipated pleasantness of drug usage, and the expected incidence of side-effect occurrence. A sample of 669 individuals participated in a 2 x 8 complete factorial design. The design manipulated the number of side effects associated with drug use and the type of qualifying language used to describe the side effects. The eight experimental qualifying language cells represented one control condition (no qualifying language), three cells where each of three types of qualifying language were presented individually, and four cells where qualifying language was combined. The results indicate that qualifying language has a profound effect on drug perceptions, especially when used in combination. Drug appeal and the anticipated drug-using experience almost always were more positive in the presence of qualifying language. Qualifying language appears to exert its influence by causing individuals to reduce their estimate of the likelihood of experiencing individual side effects. Policy implications of the research, particularly for evaluation of “fair balance” and the reporting of side effects, are presented.  
  Call Number Serial 1390  
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Author (up) Ege, M.J.; Mayer, M.; Normand, A.-C.; Genuneit, J.; Cookson, W.O.C.M.; Braun-Fahrlander, C.; Heederik, D.; Piarroux, R.; von Mutius, E. file  url
  Title Exposure to environmental microorganisms and childhood asthma Type Journal Article
  Year 2011 Publication The New England Journal of Medicine Abbreviated Journal N Engl J Med  
  Volume 364 Issue 8 Pages 701-709  
  Keywords Adolescent; *Agriculture; Asthma/*epidemiology/immunology; Bacteria/*isolation & purification; Biodiversity; Child; Cross-Sectional Studies; Dust/analysis; Environmental Exposure/*analysis; Female; Fungi/*isolation & purification; Humans; Hypersensitivity/*epidemiology/immunology; Immunoglobulin E/blood; Logistic Models; Male; Microbiome; Polymorphism, Single-Stranded Conformational; Prevalence; Risk Factors; Surveys and Questionnaires  
  Abstract BACKGROUND: Children who grow up in environments that afford them a wide range of microbial exposures, such as traditional farms, are protected from childhood asthma and atopy. In previous studies, markers of microbial exposure have been inversely related to these conditions. METHODS: In two cross-sectional studies, we compared children living on farms with those in a reference group with respect to the prevalence of asthma and atopy and to the diversity of microbial exposure. In one study--PARSIFAL (Prevention of Allergy-Risk Factors for Sensitization in Children Related to Farming and Anthroposophic Lifestyle)--samples of mattress dust were screened for bacterial DNA with the use of single-strand conformation polymorphism (SSCP) analyses to detect environmental bacteria that cannot be measured by means of culture techniques. In the other study--GABRIELA (Multidisciplinary Study to Identify the Genetic and Environmental Causes of Asthma in the European Community [GABRIEL] Advanced Study)--samples of settled dust from children's rooms were evaluated for bacterial and fungal taxa with the use of culture techniques. RESULTS: In both studies, children who lived on farms had lower prevalences of asthma and atopy and were exposed to a greater variety of environmental microorganisms than the children in the reference group. In turn, diversity of microbial exposure was inversely related to the risk of asthma (odds ratio for PARSIFAL, 0.62; 95% confidence interval [CI], 0.44 to 0.89; odds ratio for GABRIELA, 0.86; 95% CI, 0.75 to 0.99). In addition, the presence of certain more circumscribed exposures was also inversely related to the risk of asthma; this included exposure to species in the fungal taxon eurotium (adjusted odds ratio, 0.37; 95% CI, 0.18 to 0.76) and to a variety of bacterial species, including Listeria monocytogenes, bacillus species, corynebacterium species, and others (adjusted odds ratio, 0.57; 95% CI, 0.38 to 0.86). CONCLUSIONS: Children living on farms were exposed to a wider range of microbes than were children in the reference group, and this exposure explains a substantial fraction of the inverse relation between asthma and growing up on a farm. (Funded by the Deutsche Forschungsgemeinschaft and the European Commission.).  
  Call Number Serial 1983  
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Author (up) Foote, H.W.; Hamer, J.D.; Roland, M.M.; Landy, S.R.; Smitherman, T.A. file  url
  Title Psychological flexibility in migraine: A study of pain acceptance and values-based action Type Journal Article
  Year 2016 Publication Cephalalgia : an International Journal of Headache Abbreviated Journal Cephalalgia  
  Volume 36 Issue 4 Pages 317-324  
  Keywords *Adaptation, Psychological; Adult; Chronic Pain/psychology; Cross-Sectional Studies; Female; Humans; Male; Migraine Disorders/*psychology; Surveys and Questionnaires; Migraine; acceptance; acceptance and commitment therapy; disability; headache; psychological flexibility  
  Abstract BACKGROUND: Studies of musculoskeletal pain patients confirm that acceptance of pain and values-based action are strong predictors of pain-related disability and that interventions fostering “psychological flexibility” confer positive outcomes. However, data on these processes in migraine remain limited. This cross-sectional study examined relations between components of psychological flexibility and headache among treatment-seeking migraineurs. METHODS: A total of 103 adults (M age = 41.5 (11.9) years; 88.2% female) with ICHD-confirmed migraine (71.8% episodic, 28.2% chronic) across three clinics completed measures of psychological flexibility and headache-related disability. Hierarchical regressions quantified relations between acceptance/values-based action and headache variables after first controlling for pain severity and gender. RESULTS: Acceptance of pain and values-based action accounted for 10% of unique variance in headache severity (DeltaR(2) p = 0.006) and up to 20% in headache-related disability (DeltaR(2) ps = 0.02 and < 0.001) but were weakly related to headache frequency. Psychological flexibility was more strongly associated with MIDAS-measured disability than was headache severity or headache frequency. Significant effects were typically of medium-to-large size and driven primarily by values-based action. CONCLUSIONS: Paralleling results from the broader chronic pain literature, pain acceptance and values-based action play significant roles in headache pain and disability. Further study of interventions targeting these processes may enhance existing treatments.  
  Call Number Serial 2062  
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Author (up) Hetherington, M.M.; Anderson, A.S.; Norton, G.N.M.; Newson, L. file  url
  Title Situational effects on meal intake: A comparison of eating alone and eating with others Type Journal Article
  Year 2006 Publication Physiology & Behavior Abbreviated Journal Physiol Behav  
  Volume 88 Issue 4-5 Pages 498-505  
  Keywords Adult; Affect/physiology; Appetite; Dietary Fats; Eating/physiology/*psychology; Energy Intake/physiology; Female; Food; Humans; Hunger/physiology; Male; Memory/physiology; *Social Environment; Social Facilitation; Surveys and Questionnaires; Television  
  Abstract Eating in competition with other tasks has been shown to increase food intake, particularly when tasks are cognitively demanding. To test the hypothesis that social facilitation of eating occurs, in part, as a function of distraction which impairs the ability to self-monitor, eating with others was compared with eating alone or in front of the television. Using a repeated measure within-subjects design, thirty-seven participants (21 males) visited the laboratory 4 times to eat a buffet-style lunch ad libitum. All eating episodes were filmed. Energy intake (EI) was measured when participants ate alone (A), ate alone while watching TV (B), ate with two same sex strangers (C), and ate with two same sex friends (D) in a counterbalanced order. EI was significantly enhanced by presence of familiar others (D: 4565+/-272 kJ, p < 0.001) and watching TV (B: 4350+/-252 kJ, p < 0.05) compared to baseline (A: 3861+/-200 kJ). Length of eating episode correlated significantly (p < 0.05) with EI, however, amount of time spent eating and looking at food differed by condition with a greater percentage of time focussed on food during baseline (p < 0.001). Eating with friends increased EI by 18% and eating in front of the TV increased EI by 14% relative to baseline. Engaging in conversation or watching TV draws attention away from the eaten food and can stimulate food intake. However, since eating with strangers also drew attention away from food but did not result in increased intake, social facilitation effects are not simply due to distraction. Thus food intake can be enhanced when attention to food and self-monitoring are impaired during distraction, however, this effect is moderated when eating with strangers.  
  Call Number Serial 1645  
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Author (up) Horstmann, A.; Dietrich, A.; Mathar, D.; Possel, M.; Villringer, A.; Neumann, J. file  url
  Title Slave to habit? Obesity is associated with decreased behavioural sensitivity to reward devaluation Type Journal Article
  Year 2015 Publication Appetite Abbreviated Journal Appetite  
  Volume 87 Issue Pages 175-183  
  Keywords Adaptation, Physiological; Adult; Body Mass Index; Body Weight; Energy Intake; Feeding Behavior/*psychology; Health Behavior; Humans; Hunger; Hyperphagia/psychology; Linear Models; Male; Models, Biological; Motivation; Obesity/*psychology; *Reward; Satiation; Surveys and Questionnaires; Young Adult; Control of food intake; Devaluation; Goal-directed; Habitual; Obesity; Reward sensitivity  
  Abstract The motivational value of food is lower during satiety compared to fasting. Dynamic changes in motivational value promote food seeking or meal cessation. In obesity this mechanism might be compromised since obese subjects ingest energy beyond homeostatic needs. Thus, lower adaptation of eating behaviour with respect to changes in motivational value might cause food overconsumption in obesity. To test this hypothesis, we implemented a selective satiation procedure to investigate the relationship between obesity and the size of the behavioural devaluation effect in humans. Lean to obese men (mean age 25.9, range 19-30 years; mean BMI 29.1, range 19.2-45.1 kg/m(2)) were trained on a free operant paradigm and learned to associate cues with the possibility to win different food rewards by pressing a button. After the initial training phase, one of the rewards was devalued by consumption. Response rates for and wanting of the different rewards were measured pre and post devaluation. Behavioural sensitivity to reward devaluation, measured as the magnitude of difference between pre and post responses, was regressed against BMI. Results indicate that (1) higher BMI compared to lower BMI in men led to an attenuated behavioural adjustment to reward devaluation, and (2) the decrease in motivational value was associated with the decrease in response rate between pre and post. Change in explicitly reported motivational value, however, was not affected by BMI. Thus, we conclude that high BMI in men is associated with lower behavioural adaptation with respect to changes in motivational value of food, possibly resulting in automatic overeating patterns that are hard to control in daily life.  
  Call Number Serial 1264  
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Author (up) Hurling, R.; Shepherd, R. file  url
  Title Eating with your eyes: effect of appearance on expectations of liking Type Journal Article
  Year 2003 Publication Appetite Abbreviated Journal Appetite  
  Volume 41 Issue 2 Pages 167-174  
  Keywords Animals; Cooking; Female; Fishes; Food; Food Preferences/*psychology; Hot Temperature; Humans; Questionnaires; *Visual Perception  
  Abstract It was hypothesised that consumers' expectations of liking for a food would be affected by its appearance both when raw and when cooked and that the impact of these expectations on actual liking for the product after eating would vary with consumer awareness of internal body states (private body consciousness). We found that consumers' expectations of liking for the food generated by the appearance of the cooked product was related to expectation of liking from viewing the raw product. Under some conditions, consumers liked a food less after consumption if a raw product that generated low expectation of liking had been presented beforehand. There was no evidence that private body consciousness modified the consumers' susceptibility to expectation effects. It was concluded that expectations of liking for a food generated by appearance both when raw and cooked influenced final evaluation of the product during consumption.  
  Call Number Serial 159  
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Author (up) Jansen, E.; Mulkens, S.; Emond, Y.; Jansen, A. file  url
  Title From the Garden of Eden to the land of plenty. Restriction of fruit and sweets intake leads to increased fruit and sweets consumption in children Type Journal Article
  Year 2008 Publication Appetite Abbreviated Journal Appetite  
  Volume 51 Issue 3 Pages 570-575  
  Keywords Analysis of Variance; Body Mass Index; Child; Child Nutritional Physiological Phenomena/physiology; Child, Preschool; Dietary Sucrose/*administration & dosage; Eating/*psychology; Energy Intake/physiology; Female; *Fruit; Humans; *Inhibition (Psychology); Male; Obesity/epidemiology/etiology/psychology; Parent-Child Relations; Parents/*psychology; Psychology, Child; Surveys and Questionnaires  
  Abstract Overweight is increasing rapidly in children, compelling researchers to seek for determinants of adverse food intake. In a previous experiment it was found that manipulating the restriction of attractive snacks increased the desirability and intake of these snacks. In the present study, we tested whether this paradoxical restricting effect is also seen in relatively less attractive but healthy food, i.e. fruit. Will fruit become more desirable through restriction, and will children eat more forbidden fruit than non-forbidden fruit? Two groups of young children were forbidden to eat fruits and sweets, respectively, whereas a control group was invited to eat everything. Desire for sweets remained high in the sweets-prohibition condition, whereas it decreased in the fruit-prohibition and no-prohibition conditions. No group differences were found regarding the desire for fruit. With respect to intake, children in both the fruit- and the sweets-prohibition condition consumed more of the formerly forbidden food during a taste session as compared to the no-prohibition condition. In addition, total food intake was higher in the two prohibition conditions than in the no-prohibition condition. These data indicate that the adverse effects of restriction apply to both attractive unhealthy and relatively less attractive but healthy food.  
  Call Number Serial 1691  
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