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Author (up) Bhadra, K.; Kumar, G.S. file  url
  Title Therapeutic potential of nucleic acid-binding isoquinoline alkaloids: binding aspects and implications for drug design Type Journal Article
  Year 2011 Publication Medicinal Research Reviews Abbreviated Journal Med Res Rev  
  Volume 31 Issue 6 Pages 821-862  
  Keywords Alkaloids/*chemistry; Animals; Benzophenanthridines/chemistry; Berberine/analogs & derivatives/chemistry; Berberine Alkaloids/chemistry; Calorimetry/methods; Chemistry, Pharmaceutical/*methods; DNA/chemistry; *Drug Design; Humans; Isoquinolines/*chemistry; Mice; Models, Chemical; Nucleic Acids/*chemistry; RNA/chemistry; Spectrophotometry/methods; Temperature  
  Abstract Isoquinoline alkaloids represent a group of natural products with remarkable importance in the contemporary biomedical research and drug discovery programs. Several members of this group exhibit immense pharmacological and biological properties, including potential anticancer properties. Although the molecular targets of these alkaloids are not yet clearly delineated, extensive research in this area continues to build up new data that are clinically exploitable. The gross structural features of many of the members DNA interaction are more or less clear, but the mystery still remains on many aspects of their binding, including specificity and energetics. RNA-binding aspects of these alkaloids are being elucidated. More recent advancements in analytical instrumentation have enabled clearer elucidation and correlation of the structural and energetic aspects of the interaction. In this review, we report up-to-date details of the interaction of berberine, palmatine, and jatrorrhizine of the protoberberine group, sanguinarine from the benzophananthridine group, and several of their synthetic derivatives, such as coralyne, berberrubine, palmatrubine, and jatrorubin with nucleic acids have been reviewed. These studies, taken together up to now, have led to interesting knowledge on the mode, mechanism, specificity of binding, and correlation between structural aspects and energetics enabling a complete set of guidelines for design of new drugs. In contemporary research, several derivatives of these natural alkaloids are being prepared and investigated in several laboratories for ultimate discovery of new compounds that can be used as effective therapeutic agents.  
  Call Number Serial 400  
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Author (up) Cefola, M.; Amodio, M.L.; Cornacchia, R.; Rinaldi, R.; Vanadia, S.; Colelli, G. url  doi
  Title Effect of atmosphere composition on the quality of ready-to-use broccoli raab (Brassica rapa L.) Type Journal Article
  Year 2010 Publication Journal of the Science of Food and Agriculture Abbreviated Journal J Sci Food Agric  
  Volume 90 Issue 5 Pages 789-797  
  Keywords Antioxidants--analysis; Ascorbic Acid--analysis; Brassica rapa--anatomy, histology, chemistry; Carbon Dioxide--chemistry; Cell Respiration; Chlorophyll--analysis; Fast Foods; Food Handling--methods; Nutritive Value; Odors; Oxygen--chemistry; Phenols--analysis; Pigmentation; Plant Shoots--anatomy, histology, chemistry; Quality Control; Refrigeration; Seasons; Spectrophotometry; Time Factors  
  Abstract BACKGROUND: Many leafy brassicas are widely used for ready-to-use salads. Broccoli raab (Brassica rapa L.), also called turnip top, or rapini, is extensively cultivated in southern Italy. The edible portion is made up of the green, immature inflorescences and the stem with its most tender leaves. Recently, interest in this crop has increased among European consumers; moreover, a substantial increase in consumption could come from the ready-to-use product. RESULTS: The effects of four different atmosphere compositions (air, 3% O(2) in nitrogen, 3% O(2) + 10% CO(2) in air, and 10% CO(2) in air) on quality attributes of ready-to-use broccoli raab were studied. Controlled atmosphere affected appearance, composition, respiration rate, weight loss, and presence of off-odours. Storage of broccoli raab florets under low oxygen conditions delayed post-cutting deterioration during storage at 5 degrees C and preserved appearance and typical odour, up to 17 days. Moreover, respiration rate as well as loss of green colour, chlorophyll and vitamin C were also slowed down in this condition. Finally, in this study no effect of controlled atmosphere storage was found on total phenols content and antioxidant activity. CONCLUSION: Results showed that cold storage in 3% O(2) can be beneficial in order to maintain quality of ready-to-use, broccoli raab for up to 17 days.  
  Call Number Serial 41  
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Author (up) Lapenda, J.C.; Silva, P.A.; Vicalvi, M.C.; Sena, K.X.F.R.; Nascimento, S.C. file  url
  Title Antimicrobial activity of prodigiosin isolated from Serratia marcescens UFPEDA 398 Type Journal Article
  Year 2015 Publication World Journal of Microbiology & Biotechnology Abbreviated Journal World J Microbiol Biotechnol  
  Volume 31 Issue 2 Pages 399-406  
  Keywords Acinetobacter/drug effects; Anti-Bacterial Agents/chemistry/*pharmacology; Bacteria/*drug effects/growth & development; Disk Diffusion Antimicrobial Tests; Enterococcus faecalis/drug effects; Escherichia coli/drug effects; Prodigiosin/chemistry/*pharmacology; Pseudomonas aeruginosa/drug effects; Serratia marcescens/*chemistry; Spectrophotometry; Staphylococcus aureus/drug effects; Streptococcus pyogenes/drug effects  
  Abstract Prodigiosin is an alkaloid and natural red pigment produced by Serratia marcescens. Prodigiosin has antimicrobial, antimalarial and antitumor properties and induces apoptosis in T and B lymphocytes. These properties have piqued the interest of researchers in the fields of medicine, pharmaceutics and different industries. The aim of the present study was to evaluate the antimicrobial activity of prodigiosin against pathogenic micro-organisms. The red pigments produced by S. marcescens exhibited absorption at 534 nm, Rf of 0.59 and molecular weight of 323 m/z. Antimicrobial activity was tested against oxacillin-resistant Escherichia coli, Pseudomonas aeruginosa, Staphylococcus aureus, Enterococcus faecalis, Streptococcus pyogenes, Acinetobacter sp. and oxacillin-resistant S. aureus. The standard antibiotics employed were ampicillin, chloramphenicol, gentamicin and oxacillin. The disc-diffusion tests demonstrated significant inhibition zones for S. aureus (35 +/- 0.6), E. faecalis (22 +/- 1.0) and S. pyogenes (14 +/- 0.6). However, prodigiosin showed resistance to E. coli, P. aeruginosa and acinetobacter, where no significant formation of inhibitory halos were observed. We determined the inhibitory minimum concentrations and bactericidal for 20 strains of oxacillin-resistant S. aureus (ORSA). The pattern was the antibiotic oxacillin. The minimum inhibitory concentrations observed ranged from 1, 2 and 4.0 mug/mL, respectively, while the minimum bactericidal concentrations ranged from 2, 4, 8 and 16 mug/mL. The S. marcescens prodigiosin produced by showed bactericidal and bacteriostatic effect showing promising antimicrobial activity and suggesting future studies regarding its applicability in antibiotics therapies directed ORSA.  
  Call Number Serial 1672  
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Author (up) Schechter, A.N.; Epstein, C.J. file  url
  Title Spectral studies on the denaturation of myoglobin Type Journal Article
  Year 1968 Publication Journal of Molecular Biology Abbreviated Journal J Mol Biol  
  Volume 35 Issue 3 Pages 567-589  
  Keywords Animals; Cetacea; Chemical Phenomena; Chemistry; Fluorometry; *Guanidines; Horses; Myoglobin/*analysis; Optical Rotatory Dispersion; *Protein Denaturation; Spectrophotometry; Spectrum Analysis; *Urea  
  Abstract Absorption and fluorescence spectroscopy and optical rotation measurements have been used to follow the denaturation of sperm whale skeletal muscle and horse heart myoglobins by urea and guanidine hydrochloride. The spectral properties of the metmyoglobin forms of each of these proteins change concomitantly during denaturation, and the transitions are compatible with a one-step, cooperative denaturation process. The apomyoglobins from sperm whale and horse undergo transitions at lower concentrations of denaturants than do their respective metmyoglobins, and the data are again compatible with a one-step process. For both metmyoglobins and apomyoglobins, the protein from the sperm whale is significantly more stable than that from the horse. These results are discussed with respect to the chemical bases of the spectral properties, the location and relationship of the chromophores in the atomic model of the protein, and the forces which lead to structural stability.  
  Call Number Serial 380  
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Author (up) Thaker, B.T.; Barvalia, R.S. file  url
doi  openurl
  Title Microwave assisted synthesis and characterization of unsymmetrical tetradentate Schiff base complexes of VO(IV) and MoO(V) Type Journal Article
  Year 2011 Publication Spectrochimica Acta. Part A, Molecular and Biomolecular Spectroscopy Abbreviated Journal Spectrochim Acta A Mol Biomol Spectrosc  
  Volume 84 Issue 1 Pages 51-61  
  Keywords Electron Spin Resonance Spectroscopy; Electrons; Ligands; Magnetic Phenomena; Magnetic Resonance Spectroscopy; Mass Spectrometry; *Microwaves; Molybdenum/*chemistry; Oxides/*chemistry; Physical Phenomena; Powders; Schiff Bases/*chemical synthesis/*chemistry; Spectrophotometry, Ultraviolet; Spectroscopy, Fourier Transform Infrared; Stereoisomerism; Temperature; Thermogravimetry; Vanadates/*chemistry  
  Abstract Microwave synthesis, is green chemical method, simple, sensitive, reducing solvent amount and reaction time. The attempt was made to synthesize the unsymmetrical tetradentate N(2)O(2) ligands and their VO(IV) and MoO(V) unsymmetrical tetradentate Schiff base complexes by classical and microwave techniques using domestic microwave oven. The resulting unsymmetrical Schiff base ligands L(1)-L(3) characterized by different spectral methods. Their complexes with oxocations of VO(IV) and MoO(V) have been synthesized and characterized by elemental analyses, conductometric measurements, infrared and electronic absorption, (1)H NMR spectra, mass spectrometry, ESR spectra, magnetic susceptibility measurement and thermal study. The study suggests that the oxo metal ion is bonded to the ligand through the oxygen and imino nitrogen and the geometry around metal ion is distorted octahedral.  
  Call Number Serial 426  
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