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Author Gajer, P.; Brotman, R.M.; Bai, G.; Sakamoto, J.; Schutte, U.M.E.; Zhong, X.; Koenig, S.S.K.; Fu, L.; Ma, Z.S.; Zhou, X.; Abdo, Z.; Forney, L.J.; Ravel, J. file  url
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Title Temporal dynamics of the human vaginal microbiota Type Journal Article
Year 2012 Publication Science Translational Medicine Abbreviated Journal Sci Transl Med  
Volume 4 Issue 132 Pages 132ra52  
Keywords Bacteria/classification/genetics; Female; Humans; Magnetic Resonance Spectroscopy; Metabolome; Metabolomics; Metagenome/genetics/*physiology; Models, Biological; Phylogeny; Time Factors; Vagina/*microbiology; Microbiome  
Abstract Elucidating the factors that impinge on the stability of bacterial communities in the vagina may help in predicting the risk of diseases that affect women's health. Here, we describe the temporal dynamics of the composition of vaginal bacterial communities in 32 reproductive-age women over a 16-week period. The analysis revealed the dynamics of five major classes of bacterial communities and showed that some communities change markedly over short time periods, whereas others are relatively stable. Modeling community stability using new quantitative measures indicates that deviation from stability correlates with time in the menstrual cycle, bacterial community composition, and sexual activity. The women studied are healthy; thus, it appears that neither variation in community composition per se nor higher levels of observed diversity (co-dominance) are necessarily indicative of dysbiosis.  
Call Number Serial 2175  
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Author Solt, I. file  url
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Title The human microbiome and the great obstetrical syndromes: a new frontier in maternal-fetal medicine Type Journal Article
Year 2015 Publication Best Practice & Research. Clinical Obstetrics & Gynaecology Abbreviated Journal Best Pract Res Clin Obstet Gynaecol  
Volume 29 Issue 2 Pages 165-175  
Keywords Chorioamnionitis/microbiology; Diabetes, Gestational/microbiology; Female; Fetal Growth Retardation/microbiology; Humans; Maternal-Fetal Exchange; *Microbiota; Placenta/microbiology; Pre-Eclampsia/microbiology; Pregnancy; Pregnancy Complications/*microbiology; Premature Birth/microbiology; Syndrome; Uterus/*microbiology; Vagina/*microbiology; bacteria; infection; inflammation; maternal-fetal medicine; microbiome; pregnancy  
Abstract The emergence of the concept of the microbiome, together with the development of molecular-based techniques, particularly polymerase chain reaction (PCR) amplification using the 16S ribosomal RNA (rRNA) gene, has dramatically increased the detection of microorganisms, the number of known species, and the understanding of bacterial communities that are relevant to maternal-fetal medicine in health and disease. Culture-independent methods enable characterization of the microbiomes of the reproductive tract of pregnant and nonpregnant women, and have increased our understanding of the role of the uterine microbiome in adverse obstetric outcomes. While bacterial ascent from the vaginal tract is recognized as the primary cause of intrauterine infection, the microbiomes of the gastrointestinal, oral, and respiratory tracts are shown to be involved by means of hematogenous spread. The transmission of maternal microbiomes to the neonate, by vaginal delivery or cesarean section, is shown to affect health from birth to adulthood.  
Call Number Serial 2079  
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