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Author (up) Flores-Mireles, A.L.; Walker, J.N.; Caparon, M.; Hultgren, S.J. file  url
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  Title Urinary tract infections: epidemiology, mechanisms of infection and treatment options Type Journal Article
  Year 2015 Publication Nature Reviews. Microbiology Abbreviated Journal Nat Rev Microbiol  
  Volume 13 Issue 5 Pages 269-284  
  Keywords Anti-Bacterial Agents/therapeutic use; Bacterial Infections/*drug therapy/economics/*epidemiology/microbiology; Humans; Risk Factors; Urinary Tract Infections/*drug therapy/economics/*epidemiology/microbiology  
  Abstract Urinary tract infections (UTIs) are a severe public health problem and are caused by a range of pathogens, but most commonly by Escherichia coli, Klebsiella pneumoniae, Proteus mirabilis, Enterococcus faecalis and Staphylococcus saprophyticus. High recurrence rates and increasing antimicrobial resistance among uropathogens threaten to greatly increase the economic burden of these infections. In this Review, we discuss how basic science studies are elucidating the molecular details of the crosstalk that occurs at the host-pathogen interface, as well as the consequences of these interactions for the pathophysiology of UTIs. We also describe current efforts to translate this knowledge into new clinical treatments for UTIs.  
  Call Number Serial 1181  
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