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Author (up) Rescigno, M. file  url
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  Title Dendritic cell functions: Learning from microbial evasion strategies Type Journal Article
  Year 2015 Publication Seminars in Immunology Abbreviated Journal Semin Immunol  
  Volume 27 Issue 2 Pages 119-124  
  Keywords Animals; Bacteria/immunology; Dendritic Cells/cytology/*immunology; Humans; Immune Evasion; Immune Tolerance; Macrophages/immunology; Phagocytosis; T-Lymphocytes/immunology; Dendritic cells; Immune evasion; Pathogens; Tolerance  
  Abstract Dendritic cells (DCs) are specialized antigen presenting cells (APC) that are fundamental to initiate both immunity and tolerance. DCs play a 'sentinel' role to protect our body from potential pathogens and induce tolerogenic responses toward harmless antigens. The flexibility of DCs or macrophages to adapt to the environment and to respond accordingly can be hijacked by pathogens for their own interest to transform a potentially immunogenic APC into a tolerogenic cell with clear consequences in pathogen clearance. While these immune evasion mechanisms can be detrimental for the host, they can highlight important molecular pathways in DCs necessary for their function. In this review we will mention several mechanisms employed by pathogens to evade DC patrolling function.  
  Call Number Serial 1703  
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