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Author (up) Driscoll, M.; Gerstbrein, B. file  url
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  Title Dying for a cause: invertebrate genetics takes on human neurodegeneration Type Journal Article
  Year 2003 Publication Nature Reviews. Genetics Abbreviated Journal Nat Rev Genet  
  Volume 4 Issue 3 Pages 181-194  
  Keywords Alzheimer Disease/genetics/pathology; Animals; Animals, Genetically Modified; Caenorhabditis elegans/cytology/genetics; Cell Death; Drosophila melanogaster/cytology/genetics; Humans; Hypoxia/genetics/pathology; Invertebrates/cytology/*genetics; Ion Channels/metabolism; Models, Neurological; Mutation; Nerve Degeneration/*genetics/*pathology; Neurons/drug effects/pathology; Parkinson Disease/genetics/pathology; Peptides/genetics  
  Abstract If invertebrate neurons are injured by hostile environments or aberrant proteins they die much like human neurons, indicating that the powerful advantages of invertebrate molecular genetics might be successfully used for testing specific hypotheses about human neurological diseases, for drug discovery and for non-biased screens for suppressors and enhancers of neurodegeneration. Recent molecular dissection of the genetic requirements for hypoxia, excitotoxicity and death in models of Alzheimer disease, polyglutamine-expansion disorders, Parkinson disease and more, is providing mechanistic insights into neurotoxicity and suggesting new therapeutic interventions. An emerging theme is that neuronal crises of distinct origins might converge to disrupt common cellular functions, such as protein folding and turnover.  
  Call Number Serial 1706  
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