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Author (up) Gitter, A.H.; Zenner, H.P.; Fromter, E. file  url
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  Title Membrane potential and ion channels in isolated outer hair cells of guinea pig cochlea Type Journal Article
  Year 1986 Publication ORL; Journal for oto-Rhino-Laryngology and its Related Specialties Abbreviated Journal ORL J Otorhinolaryngol Relat Spec  
  Volume 48 Issue 2 Pages 68-75  
  Keywords Animals; Cells, Cultured; Chlorine/metabolism; Guinea Pigs; Hair Cells, Auditory/*physiology/ultrastructure; Ion Channels/*physiology; Membrane Potentials; Potassium/metabolism  
  Abstract Single outer hair cells from guinea pig cochlea were prepared by microdissection and cultured for several hours in a modified Hanks' medium. Cells, which were viable, judged by morphological criteria, were investigated with the patch-clamp technique. Membrane potentials up to -70 mV could be measured in the cultured cells. Ion channels were found in the basolateral membrane and in the cuticular region of the hair cells. These ion channels could play an important role in transducing sound-induced sterociliary motion into membrane depolarizations, thereby regulating the contractile state of the outer hair cells and in turn the resonance properties of the cochlear amplifier.  
  Call Number Serial 1998  
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