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Author (up) Campbell, C.R.; Voyles, J.; Cook, D.I.; Dinudom, A. file  url
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  Title Frog skin epithelium: electrolyte transport and chytridiomycosis Type Journal Article
  Year 2012 Publication The International Journal of Biochemistry & Cell Biology Abbreviated Journal Int J Biochem Cell Biol  
  Volume 44 Issue 3 Pages 431-434  
  Keywords Animals; Anura/*metabolism/*microbiology; Biological Transport; *Chytridiomycota; Dermis/metabolism/microbiology/pathology; Electrolytes/metabolism; Epidermis/metabolism/microbiology/pathology; Skin/*metabolism/*microbiology/pathology; Sodium Channels/metabolism; *Water-Electrolyte Balance; Xenopus  
  Abstract One unique physiological characteristic of frogs is that their main route for intake of water is across the skin. In these animals, the skin acts in concert with the kidney and urinary bladder to maintain electrolyte homeostasis. Water absorption across the skin is driven by the osmotic gradient that develops as a consequence of solute transport. Our recent study demonstrated that chytridiomycosis, an infection of amphibian skin by the fungal pathogen, Batrachochytrium dendrobatidis, inhibits epithelial Na(+) channels, attenuating Na(+) absorption through the skin. In frogs that become severely affected by this fungus, systemic depletion of Na(+), K(+) and Cl(-) is thought to cause deterioration of cardiac electrical function, leading to cardiac arrest. Here we review the ion transport mechanisms of frog skin, and discuss the effect of chytridiomycosis on these mechanisms.  
  Call Number Serial 2153  
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