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Author (up) Curtis, A.; Lyons, V.; Fink, G. file  url
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  Title The human hypothalamic LHRH precursor is the same size as that in rat and mouse hypothalamus Type Journal Article
  Year 1983 Publication Biochemical and Biophysical Research Communications Abbreviated Journal Biochem Biophys Res Commun  
  Volume 117 Issue 3 Pages 872-877  
  Keywords Aged; Animals; Female; Gonadotropin-Releasing Hormone/*biosynthesis; Humans; Hypothalamus/*metabolism; Male; Mice; Molecular Weight; Protein Biosynthesis; Protein Precursors/*isolation & purification; Rats; Species Specificity  
  Abstract The synthesis of the decapeptide luteinizing hormone releasing hormone (LHRH) in human, rat and mouse brain has been investigated by studying the in vitro translation products of Poly A+ mRNA extracts from the hypothalamus. The translation products of all three species contained a single 28000 MW polypeptide which immunoprecipitated with a specific anti-LHRH serum. This polypeptide was not present in the translation products of Poly A+ mRNA extracts from the hypothalamus of the hypogonadal mouse, a mutant strain totally deficient in LHRH. These results show that in the human, rat and normal mouse, LHRH is synthesized as a component of a precursor peptide with a molecular weight of 28000.  
  Call Number Serial 325  
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