more information
Search within Results:

Select All    Deselect All
 |   | 
  Records Links
Author (up) Alapin, I.; Fichten, C.S.; Libman, E.; Creti, L.; Bailes, S.; Wright, J. file  url
  Title How is good and poor sleep in older adults and college students related to daytime sleepiness, fatigue, and ability to concentrate? Type Journal Article
  Year 2000 Publication Journal of Psychosomatic Research Abbreviated Journal J Psychosom Res  
  Volume 49 Issue 5 Pages 381-390  
  Keywords Adaptation, Psychological; Adult; Aged; Attention; Circadian Rhythm--physiology; Cognition Disorders--diagnosis, etiology; Disorders of Excessive Somnolence--diagnosis, etiology; Fatigue--diagnosis, etiology; Female; Humans; Male; Middle Aged; Severity of Illness Index; Sleep--physiology; Sleep Initiation and Maintenance Disorders--complications, diagnosis; Students; Universities; Wakefulness--physiology  
  Abstract We compared good sleepers with minimally and highly distressed poor sleepers on three measures of daytime functioning: self-reported fatigue, sleepiness, and cognitive inefficiency. In two samples (194 older adults, 136 college students), we tested the hypotheses that (1) poor sleepers experience more problems with daytime functioning than good sleepers, (2) highly distressed poor sleepers report greater impairment in functioning during the day than either good sleepers or minimally distressed poor sleepers, (3) daytime symptoms are more closely related to psychological adjustment and to psychologically laden sleep variables than to quantitative sleep parameters, and (4) daytime symptoms are more closely related to longer nocturnal wake times than to shorter sleep times. Results in both samples indicated that poor sleepers reported more daytime difficulties than good sleepers. While low- and high-distress poor sleepers did not differ on sleep parameters, highly distressed poor sleepers reported consistently more difficulty in functioning during the day and experienced greater tension and depression than minimally distressed poor sleepers. Severity of all three daytime problems was generally significantly and positively related to poor psychological adjustment, psychologically laden sleep variables, and, with the exception of sleepiness, to quantitative sleep parameters. Results are used to discuss discrepancies between experiential and quantitative measures of daytime functioning.  
  Call Number Serial 216  
Permanent link to this record

Author (up) Anderson, R.P.; Degano, P.; Godkin, A.J.; Jewell, D.P.; Hill, A.V. file  url
  Title In vivo antigen challenge in celiac disease identifies a single transglutaminase-modified peptide as the dominant A-gliadin T-cell epitope Type Journal Article
  Year 2000 Publication Nature Medicine Abbreviated Journal Nat Med  
  Volume 6 Issue 3 Pages 337-342  
  Abstract Celiac disease (CD) is an increasingly diagnosed enteropathy (prevalence, 1:200-1:300) that is induced by dietary exposure to wheat gliadins (as well as related proteins in rye and barley) and is strongly associated with HLA-DQ2 (alpha1*0501, beta1*0201), which is present in over 90% of CD patients. Because a variety of gliadin peptides have been identified as epitopes for gliadin-specific T-cell clones and as bioactive sequences in feeding studies and in ex vivo CD intestinal biopsy challenge, it has been unclear whether a 'dominant' T-cell epitope is associated with CD. Here, we used fresh peripheral blood lymphocytes from individual subjects undergoing short-term antigen challenge and tissue transglutaminase-treated, overlapping synthetic peptides spanning A-gliadin to demonstrate a transient, disease-specific, DQ2-restricted, CD4 T-cell response to a single dominant epitope. Optimal gamma interferon release in an ELISPOT assay was elicited by a 17-amino-acid peptide corresponding to the partially deamidated peptide of A-gliadin amino acids 57-73 (Q65E). Consistent with earlier reports indicating that host tissue transglutaminase modification of gliadin enhances gliadin-specific CD T-cell responses, tissue transglutaminase specifically deamidated Q65 in the peptide of A-gliadin amino acids 56-75. Discovery of this dominant epitope may allow development of antigen-specific immunotherapy for CD.

Subject Headings: Adult; Age of Onset; Amino Acid Sequence; Celiac Disease/epidemiology/genetics/*immunology; Cells, Cultured; Epitopes/chemistry/*immunology; Female; Gliadin/chemistry/*immunology/pharmacology; HLA-DQ Antigens/genetics/immunology; Humans; Interferon-gamma/biosynthesis; Interleukin-10/biosynthesis; Lymphocyte Activation; Lymphocytes/drug effects/immunology; Male; Middle Aged; Molecular Sequence Data; Peptide Fragments/*immunology/pharmacology; Prevalence; T-Lymphocytes/*immunology; Transglutaminases/*metabolism; United Kingdom/epidemiology

Keywords: In vivo antigen challenge in celiac disease identifies a single transglutaminase-modified peptide as the dominant A-gliadin T-cell epitope
  Call Number Serial 2522  
Permanent link to this record

Author (up) Baselga, J.; Pfister, D.; Cooper, M.R.; Cohen, R.; Burtness, B.; Bos, M.; D'Andrea, G.; Seidman, A.; Norton, L.; Gunnett, K.; Falcey, J.; Anderson, V.; Waksal, H.; Mendelsohn, J. file  url
  Title Phase I studies of anti-epidermal growth factor receptor chimeric antibody C225 alone and in combination with cisplatin Type Journal Article
  Year 2000 Publication Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology Abbreviated Journal J Clin Oncol  
  Volume 18 Issue 4 Pages 904-914  
  Keywords Adult; Antibodies, Monoclonal/adverse effects/pharmacokinetics/*therapeutic use; Antibodies, Monoclonal, Humanized; Antineoplastic Agents/adverse effects/pharmacokinetics/*therapeutic use; Area Under Curve; Carcinoma, Non-Small-Cell Lung/drug therapy/therapy; Carcinoma, Squamous Cell/drug therapy/therapy; Cetuximab; Cisplatin/*therapeutic use; Dose-Response Relationship, Drug; Drug Administration Schedule; Female; Gene Expression Regulation, Neoplastic; Head and Neck Neoplasms/drug therapy/therapy; Humans; Infusions, Intravenous; Lung Neoplasms/drug therapy/therapy; Male; Neoplasms, Glandular and Epithelial/drug therapy/*therapy; Receptor, Epidermal Growth Factor/*antagonists & inhibitors/genetics; Recombinant Fusion Proteins/adverse effects/pharmacokinetics/*therapeutic use; Remission Induction; Safety  
  Abstract PURPOSE: The epidermal growth factor (EGF) receptor is frequently overexpressed in epithelial tumors. C225 is a human-to-murine chimeric monoclonal antibody that binds to the receptor and inhibits growth of cancer cells expressing the receptor. We evaluated the pharmacokinetics and toxicity of C225 in patients with advanced tumors overexpressing EGF receptors. PATIENTS AND METHODS: We treated 52 patients in three successive phase I clinical trials of C225 as a single dose (n = 13), weekly multiple dose (n = 17), and weekly multiple dose with cisplatin (n = 22). C225 dose levels were 5, 20, 50, and 100 mg/m(2). In the study combining C225 with cisplatin, limited to patients with either head and neck or non-small-cell lung cancer, C225 was further escalated to 200 and 400 mg/m(2). Cisplatin was given at a dose of 60 mg/m(2) once every 4 weeks, and treatment was continued for up to 12 weeks if no disease progression occurred. RESULTS: C225 displayed nonlinear pharmacokinetics, with antibody doses in the range of 200 to 400 mg/m(2) being associated with complete saturation of systemic clearance. C225 clearance did not change with repeated administration or with coadministration of cisplatin. Antibodies against C225 were detected in only one patient, and C225-associated toxicity was minimal. Patients experiencing disease stabilization were seen in all studies. In the study combining C225 and cisplatin, nine (69%) of 13 patients treated with antibody doses >/= 50 mg/m(2) completed 12 weeks of therapy, and two partial responses were observed. CONCLUSION: C225 has dose-dependent pharmacokinetics, and doses that achieve saturation of systemic clearance are well tolerated. C225 given in combination with cisplatin has biologic activity at pharmacologically relevant doses.  
  Call Number Serial 2015  
Permanent link to this record

Author (up) Bechara, A. file  url
  Title Emotion, Decision Making and the Orbitofrontal Cortex Type Journal Article
  Year 2000 Publication Cerebral Cortex Abbreviated Journal  
  Volume 10 Issue 3 Pages 295-307  
  Keywords emotion; decision making; gambling; memory, short-term; orbitofrontal cortex  
  Abstract The somatic marker hypothesis provides a systems-level neuroanatomical and cognitive framework for decision making and the influence on it by emotion. The key idea of this hypothesis is that decision making is a process that is influenced by marker signals that arise in bioregulatory processes, including those that express themselves in emotions and feelings. This influence can occur at multiple levels of operation, some of which occur consciously and some of which occur non-consciously. Here we review studies that confirm various predictions from the hypothesis. The orbitofrontal cortex represents one critical structure in a neural system subserving decision making. Decision making is not mediated by the orbitofrontal cortex alone, but arises from large-scale systems that include other cortical and subcortical components. Such structures include the amygdala, the somatosensory/insular cortices and the peripheral nervous system. Here we focus only on the role of the orbitofrontal cortex in decision making and emotional processing, and the relationship between emotion, decision making and other cognitive functions of the frontal lobe, namely working memory.  
  Call Number Serial 1975  
Permanent link to this record

Author (up) Bennett, J.W.; Bentley, R. file  url
  Title Seeing red: the story of prodigiosin Type Journal Article
  Year 2000 Publication Advances in Applied Microbiology Abbreviated Journal Adv Appl Microbiol  
  Volume 47 Issue Pages 1-32  
  Keywords Bacteriology/history; Bread/microbiology; History, 18th Century; History, 19th Century; History, 20th Century; Pigments, Biological/*chemistry/history/metabolism/pharmacology; Prodigiosin/*chemistry/metabolism/pharmacology; Serratia marcescens/*chemistry/metabolism  
  Abstract S. marcescens has played an important role in the history of bacterial taxonomy, in research on the transmission of bacterial aerosols, in the study of emerging nosocomial infections, and in the understanding of secondary metabolite biosynthesis. The prodigiosin pigments have intrigued organic chemists and pharmacologists, and play roles in the treatment of infectious diseases such as malaria, and perhaps as immunosuppressant agents. Undecylprodiginine played an important role in the first cloning of a gene, playing a defined role in the biosynthesis of an antibiotic. An O-methyltransferase gene was isolated by complementation and the color of undecylprodiginine was used as the selectable phenotype. The regulation of prodigiosin biosynthesis is complex, being influenced by increased glucose levels and decreased by increased phosphate level. The antibiotic resistance of many strains of S. marcescens is a serious problem with rapid horizontal transfer of drug resistance by plasmids.  
  Call Number Serial 1639  
Permanent link to this record

Author (up) Bickerdike, A.J.; Littlefield, L. file  url
  Title Divorce adjustment and mediation: Theoretically grounded process research Type Journal Article
  Year 2000 Publication Conflict Resolution Quarterly Abbreviated Journal Conflict Resolution Quarterly  
  Volume 18 Issue 2 Pages 181-201  
  Keywords Divorce; Adjustment; Mediation; Outcome; Behavior  
  Abstract Drawing on models of the divorce adjustment process, conflict theory, and previous research, a number of hypotheses were derived about the influence of divorce process variables on disputant behavior in mediation and mediation outcome. Premediation levels of attachment, anger, and sadness were assessed in 112 couples and the mediation sessions of fifty of these were videotaped. An existing coding instrument was modified to quantify disputant behaviors. Specific behaviors in mediation were found to be predictive of mediation outcome. Antecedent attachment and anger were found to be predictive of behavior in mediation and mediation outcome. In this article, the implications for mediation practice are discussed.  
  Call Number Serial 567  
Permanent link to this record

Author (up) Bolling, J.D.; Walker, L.R. file  url
  Title Plant and soil recovery along a series of abandoned desert roads Type Journal Article
  Year 2000 Publication Journal of Arid Environments Abbreviated Journal Journal of Arid Environments  
  Volume 46 Issue 1 Pages 1-24  
  Keywords disturbance; Larrea; Mojave Desert; revegetation; soil recovery  
  Abstract Soil and vegetation dynamics were examined along roads abandoned for 5, 10, 21, 31, 55 and 88 years in southern Nevada in an attempt to elucidate factors controlling desert succession. None of the measured soil or vegetation parameters varied significantly with road age. Differences were found, however, between soils and vegetation on roads vs. nearby controls, and soils differed between roads created by surface vehicular traffic and bulldozing. Studies of recovery following disturbance in deserts must take into account natural patterns of plant and soil heterogeneity and initial disturbance type.  
  Call Number Serial 1616  
Permanent link to this record

Author (up) Burke, T.A.; Litt, J.S.; Fox, M.A. file  url
  Title Linking public health and the health of the Chesapeake Bay Type Journal Article
  Year 2000 Publication Environmental Research Abbreviated Journal Environ Res  
  Volume 82 Issue 2 Pages 143-149  
  Keywords *Environmental Health; Humans; Maryland; *Public Health; *Risk Management; Seawater; Water Pollution/*prevention & control  
  Abstract The Chesapeake Bay has a profound impact on the lives of all who reside in the 64,000 square miles of its watershed. From crab cakes to sail-boats, drinking water to naval ships, the Bay touches virtually every aspect of life in the region. The Bay has inspired literature, driven the regional economy, and shaped political decision making and development patterns for homes, industry, agriculture, and transportation. As population demands increase and urban boundaries expand into pristine landscapes, the sustainability of the Chesapeake Bay and its resources face unprecedented pressures. Consequently, the public's health also is vulnerable to Bay pollution and other stresses stemming from development activities and widespread growth occurring throughout the Chesapeake Bay watershed. This paper will examine the linkages between the environmental quality of the Bay and the population health status, recommend ways to bridge ecological and human health concerns in the context of the Bay, and finally present a framework for developing a public health report card for the Bay.  
  Call Number Serial 923  
Permanent link to this record

Author (up) Burton, D.L. file  url
  Title Were adolescent sexual offenders children with sexual behavior problems? Type Journal Article
  Year 2000 Publication Sexual Abuse : a Journal of Research and Treatment Abbreviated Journal Sex Abuse  
  Volume 12 Issue 1 Pages 37-48  
  Abstract This article compares responses of three groups of incarcerated adolescents who admitted to sexual offending in an anonymous survey project on measures of trauma, sexual offending, the relationship between trauma and perpetration, and adjudication status. The first group admitted to sexual offending before the age of 12 only (n = 48), the second after the age of 12 only (n = 130), and the third before and after the age of 12 (n = 65). More than 46% of the sexually aggressive adolescents began their deviant behaviors before the age of 12. Level and complexity of perpetration acts were more severe for the continuous offenders than for the other groups. Victimization and perpetration were significantly correlated for all three groups. This study supports a social learning hypothesis for the development of sexual offending by adolescents. Implications for research and clinical practice are drawn.

Subject Headings: Adolescent; Adolescent Behavior/*psychology; Adult; Child; Child Abuse, Sexual/*psychology; Child Behavior/*psychology; Crime Victims/*psychology; Cross-Sectional Studies; Humans; Male; Sex Offenses/*psychology; Surveys and Questionnaires; Trauma Severity Indices
  Call Number Serial 2195  
Permanent link to this record

Author (up) Bush; Luu; Posner file  url
  Title Cognitive and emotional influences in anterior cingulate cortex Type Journal Article
  Year 2000 Publication Trends in Cognitive Sciences Abbreviated Journal Trends Cogn Sci  
  Volume 4 Issue 6 Pages 215-222  
  Keywords Error monitoring; EEG; Affective division; Cognitive division; Error-related negativity  
  Abstract Anterior cingulate cortex (ACC) is a part of the brain's limbic system. Classically, this region has been related to affect, on the basis of lesion studies in humans and in animals. In the late 1980s, neuroimaging research indicated that ACC was active in many studies of cognition. The findings from EEG studies of a focal area of negativity in scalp electrodes following an error response led to the idea that ACC might be the brain's error detection and correction device. In this article, these various findings are reviewed in relation to the idea that ACC is a part of a circuit involved in a form of attention that serves to regulate both cognitive and emotional processing. Neuroimaging studies showing that separate areas of ACC are involved in cognition and emotion are discussed and related to results showing that the error negativity is influenced by affect and motivation. In addition, the development of the emotional and cognitive roles of ACC are discussed, and how the success of this regulation in controlling responses might be correlated with cingulate size. Finally, some theories are considered about how the different subdivisions of ACC might interact with other cortical structures as a part of the circuits involved in the regulation of mental and emotional activity.  
  Call Number Serial 547  
Permanent link to this record
Select All    Deselect All
 |   | 

Save Citations: