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Author Henriksen, T.E.G.; Skrede, S.; Fasmer, O.B.; Hamre, B.; Gronli, J.; Lund, A. file  url
Title Blocking blue light during mania – markedly increased regularity of sleep and rapid improvement of symptoms: a case report Type Journal Article
Year 2014 Publication Bipolar Disorders Abbreviated Journal Bipolar Disord  
Volume 16 Issue 8 Pages 894-898  
Abstract OBJECTIVE: Available pharmacological treatment of mania is insufficient. Virtual darkness therapy (blue light-blocking treatment by means of orange-tinted glasses) is a promising new treatment option for mania. The basis for this might be the recently identified blue light-sensitive retinal photoreceptor, which is solely responsible for light stimulus to the circadian master clock. This is the first case report describing the clinical course of a closely monitored, hospitalized patient in a manic episode first receiving clear-lensed, and then blue light-blocking glasses. METHODS: A 58-year-old Caucasian man, with bipolar I disorder and three previous manic episodes, was hospitalized during a manic episode. In addition to pharmacological treatment, he was treated with clear-lensed glasses for seven days, then one day without glasses, followed by six days of blue light-blocking glasses. During the entire observational period, he wore an actigraph with internal light sensors. RESULTS: Manic symptoms were unaltered during the first seven days. The transition to the blue-blocking regime was followed by a rapid and sustained decline in manic symptoms accompanied by a reduction in total sleep, a reduction in motor activity during sleep intervals, and markedly increased regularity of sleep intervals. The patient's total length of hospital stay was 20 days shorter than the average time during his previous manic episodes. CONCLUSIONS: The unusually rapid decline in symptoms, accompanied by uniform sleep parameter changes toward markedly increased regularity, suggest that blue-blockers might be targeting a central mechanism in the pathophysiology of mania that needs to be explored both in clinical research and in basic science.

Subject headings: Bipolar Disorder/*therapy; *Color Therapy; Eyeglasses; Humans; *Light; Male; Middle Aged; Photoreceptor Cells, Vertebrate/physiology; *Sensory Deprivation; Sleep/*radiation effects; actigraphy; blue-blockers; case report; mania; sleep; virtual darkness
Call Number Serial 2363  
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Author Kotiyal, S.; Bhattacharya, S. file  url
Title Breast cancer stem cells, EMT and therapeutic targets Type Journal Article
Year 2014 Publication Biochemical and Biophysical Research Communications Abbreviated Journal Biochem Biophys Res Commun  
Volume 453 Issue 1 Pages 112-116  
Abstract A small heterogeneous population of breast cancer cells acts as seeds to induce new tumor growth. These seeds or breast cancer stem cells (BCSCs) exhibit great phenotypical plasticity which allows them to undergo “epithelial to mesenchymal transition” (EMT) at the site of primary tumor and a future reverse transition. Apart from metastasis they are also responsible for maintaining the tumor and conferring it with drug and radiation resistance and a tendency for post-treatment relapse. Many of the signaling pathways involved in induction of EMT are involved in CSC generation and regulation. Here we are briefly reviewing the mechanism of TGF-beta, Wnt, Notch, TNF-alpha, NF-kappaB, RTK signalling pathways which are involved in EMT as well as BCSCs maintenance. Therapeutic targeting or inhibition of the key/accessory players of these pathways could control growth of BCSCs and hence malignant cancer. Additionally several miRNAs are dysregulated in cancer stem cells indicating their roles as oncogenes or tumor suppressors. This review also lists the miRNA interactions identified in BCSCs and discusses on some newly identified targets in the BCSC regulatory pathways like SHIP2, nicastrin, Pin 1, IGF-1R, pro-inflammatory cytokines and syndecan which can be targeted for therapeutic achievements.

Subject headings: Breast Neoplasms/metabolism/*pathology/therapy; Epithelial-Mesenchymal Transition; Female; Humans; MicroRNAs/genetics/metabolism; Neoplastic Stem Cells/metabolism/*pathology; RNA, Neoplasm/genetics/metabolism; Signal Transduction; Bcsc; EMT signalling pathways; Therapeutic targets; miRNA
Call Number Serial 2361  
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Author Mahmoud, E.; Watson, D.A.; Lobo, R.F. file  url
Title Renewable production of phthalic anhydride from biomass-derived furan and maleic anhydride Type Journal Article
Year 2014 Publication Green Chem. Abbreviated Journal Green Chem.  
Volume 16 Issue 1 Pages 167-175  
Abstract A route to renewable phthalic anhydride (2-benzofuran-1,3-dione) from biomass-derived furan and maleic anhydride (furan-2,5-dione) is investigated. Furan and maleic anhydride were converted to phthalic anhydride in two reaction steps: Diels-Alder cycloaddition followed by dehydration. Excellent yields for the Diels-Alder reaction between furan and maleic-anhydride were obtained at room temperature and solvent-free conditions (SFC) yielding 96% exo-4,10-dioxa-tricyclo[]dec-8-ene-3,5-dione (oxanorbornene dicarboxylic anhydride) after 4 h of reaction. It is shown that this reaction is resistant to thermal runaway because of its reversibility and exothermicity. The dehydration of the oxanorbornene was investigated using mixed-sulfonic carboxylic anhydrides in methanesulfonic acid (MSA). An 80% selectivity to phthalic anhydride (87% selectivity to phthalic anhydride and phthalic acid) was obtained after running the reaction for 2 h at 298 K to form a stable intermediate followed by 4 h at 353 K to drive the reaction to completion. The structure of the intermediate was determined. This result is much better than the 11% selectivity obtained in neat MSA using similar reaction conditions.

Subject headings: Renewable; Phthalic anhydride; Furan; Maleic anhydride; Biomass
Call Number Serial 2347  
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Author Grzanka, P.R.; Mann, E.S. file  url
Title Queer youth suicide and the psychopolitics of “It Gets Better” Type Journal Article
Year 2014 Publication Sexualities Abbreviated Journal Sexualities  
Volume 17 Issue 4 Pages 369-393  
Abstract This article investigates a mass-mediated campaign against a perceived increase in suicides among gay (or presumed-to-be-gay) youth in the USA since September 2010. “It Gets Better” (IGB) became a rallying cry for “anti-bullying” activists, politicians, celebrities and ordinary people who created YouTube videos addressed to gay, lesbian, bisexual and transgender (LGBT) youth who might be considering suicide. A critical discourse analysis of a sample of IGB videos reveals a neoliberal frame that places the burden of a “better” life onto the emotional lives of LGBT youth, who are instructed to endure suffering in the interest of inevitable happiness. Drawing on Foucault and Orr's work on the construction and management of mental illness, we use the concept of “psychopower” to explore how these IGB videos render queer youth suicide both a psychological disorder and a sociological crisis for which the only viable solution is “homonormative” subjectivity.

Subject headings: Homonormativity: Mental health; Neoliberalism; Suicide; Youth
Call Number Serial 2338  
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Author Martinez-Alier, J. file  url
Title The environmentalism of the poor Type Journal Article
Year 2014 Publication Geoforum Abbreviated Journal Geoforum  
Volume 54 Issue Pages 239-241  
Abstract There are several varieties of environmentalism. Here the focus is on the environmentalism of poor or indigenous populations involved in resource extraction conflicts around the world. In their struggle to preserve their own livelihoods against mining companies, hydroelectric dams, biomass extraction and land grabbing, and oil and gas exploitation, peasant and indigenous communities have been since the 1980s and 1990s the backbone of the global environmental justice movement.

Subject Headings: Environmentalism; Poor; Conflicts; Valuation; Indigenous peoples; Environmental justice
Call Number Serial 2331  
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