Niederl, J. B., & Vogel, H. J. (1940). Aldehyde--Resorcinol Condensations1. J. Am. Chem. Soc., 62(9), 2512–2514.
Abstract: A crystalline condensation product of acetaldehyde with resorcinol has been reported by several investigators but the statements relative to the constitution of this compound are conflicting. The conventional alkylidene-diphenol as well as the acetal structure has been suggested. It is the purpose of the present investigation to contribute to the elucidation of the structure of not only this disputed compound ...
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Roberts, B. A., Cave, G. W. V., Raston, C. L., & Scott, J. L. (2001). Solvent-free synthesis of calix[4]resorcinarenes. Green Chemistry, 3(6), 280–284.
Abstract: Calix[4]resorcinarenes may be prepared in high yield and purity by direct reaction of resorcinol and benzaldehyde derivatives in the presence of a catalytic amount of solid acid and at ambient temperature under solvent-free conditions. This represents a viable alternative to traditional solution phase methodology. The solvent-free method measures up well with respect to energy usage, solvent wastes and associated hazards, reaction time and yield. In addition, the relevant benzaldehyde derivatives are prepared in polypropylene glycol, which is readily recycled.
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Fliss, H., & Menard, M. (1991). Hypochlorous acid-induced mobilization of zinc from metalloproteins. Arch Biochem Biophys, 287(1), 175–179.
Abstract: Hypochlorous acid (HOCl), a neutrophil oxidant, can contribute to tissue injury at sites of inflammation by its reactivity with protein sulfhydryls. The present study shows that physiological concentrations (50-200 microM) of HOCl can displace Zn2+ from metalloproteins, such as metallothionein and alcohol dehydrogenase, in which the metal is bound to sulfhydryls by means of thiolate (S-Zn) bonds. No mobilization of Zn2+ was observed from superoxide dismutase in which the metal is not bound to cysteine, suggesting that HOCl reacts selectively with thiolate bonds. Zn2+ mobilization, measured spectrophotometrically with the metallochromic indicator 4-(2-pyridylazo)resorcinol, was also observed from complexes of this metal with other thiol-containing compounds such as 2,3-dimercaptopropanol and metallothionein fragment 56-61. HOCl cleavage of the thiolate bonds was confirmed by the decrease in absorbance at 250 nm. This study shows for the first time that HOCl can mobilize protein-bound Zn2+ and suggests that neutrophil oxidant injury may be partially mediated by the mobilization of cellular Zn2+.
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