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Strategian Classic R. Brookmeyer, S. Gray, and C. Kawas

Projections of Alzheimer's Disease in the United States and the Public Health Impact of Delaying Disease Onset. (... the authors set out to project the future prevalence and incidence of Alzheimer's disease in the United States and the potential impact of interventions to delay the onset of the disease. Constructing a model that used age-specific incidence rates summarized from several epidemiological studies, US [United States] mortality rates, and US Bureau of the Census projections, the authors estimated the numbers of individuals in the United States with Alzheimer's disease and the numbers of newly diagnosed cases that can be expected over the next 50 years [to approximately the year 2050]. Based on their estimates, the authors reported that in 1997, the prevalence of Alzheimer's disease in the United States was 2.32 million [range: 1.09 to 4.58 million]; of these individuals, 68% were female. It is projected that the prevalence will nearly quadruple in the next 50 years, by which time approximately 1 in 45 Americans will be afflicted with the disease. Currently, the annual number of new incident cases [of Alzheimer's disease] is 360,000. If interventions could delay onset of the disease by 2 years, after 50 years there would be nearly 2 million fewer cases than projected; if onset could be delayed by 1 year, there would be nearly 800,000 fewer prevalent cases. Based on these estimated numbers and the significant social and economic cost of coping with the disease, the authors concluded that as the US population ages, Alzheimer's disease will become an enormous public health problem. Interventions that could delay disease onset even modestly would have a major public health impact. Other keywords and phrases -- AD -- from the text of the abstract)

American Journal of Public Health Volume 88, Number 9 (September 1998): 1337-1342.

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