Amyloid-Beta pores

A new way of looking at Alzheimer’s Disease?

A different perspective on the factors that cause Alzheimer’s disease? Will it help bring about successful treatments? Featured article: *Pannuzzo, M. (2021, May 29). Beta-amyloid pore linked to controlled calcium influx into the cell: A new paradigm for Alzheimer’s disease. Alzheimer’s & Dementia : The Journal of the Alzheimer’s Association. [PDF] “Despite tremendous worldwide efforts, clinical trials assessing Alzheimer’s disease (AD)-related therapeutics have been relentlessly…

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Brown fat

Brown adipose tissue/brown fat

Brown adipose tissue, or brown fat, is a type of fat cell that converts energy into body heat when food is eaten and digested, as opposed to white adipose tissue, or white fat, that is more plentiful and accumulates in noticeable parts of the body (for example, the belly) when too many calories are consumed and too few are expended through exercise. White fat is…

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Drought in California

Water, drought, and the western United States

The western United States (including parts of the Great Plains) is going through an historic period of drought–a level of extended drought that the region has not seen in potentially hundreds of years. “All told, nearly 85% of the West is suffering through drought conditions right now, according to the US Drought Monitor. Almost half the region is now in an extreme or exceptional drought,…

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Diels-Alder reaction

The Diels-Alder reaction: a mainstay of organic chemistry

The Diels-Alder reaction is one of the most important in Organic Chemistry and plays a role in the synthesis and manufacture of many products including pharmaceutical ingredients (including vitamins and drugs), agrochemicals (including fungicides), flavors, fragrances, and more. The reaction is also found in nature, in the synthesis of natural products. Background: *Boger, D. & Weinreb, S. (1987). Hetero Diels-Alder Methodology in Organic Synthesis. Organic…

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Climate change and human migration

Background: Hundreds of millions of climate migrants likely by 2050 Lustgarten, Abrahm (2020, July 23). The Great Climate Migration. New York Times Magazine. [Cited by] Migration due to climate change is already happening in the United States The research: *Koubi, V., Böhmelt, T., Spilker, G., & Schaffer, L. (2018). The determinants of environmental migrants’ conflict perception. International Organization, 72(4), 905-936. [PDF] [Cited by] “Migration is…

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Opioids: addiction and overdose — update

An update to the Opioids, addiction, and overdose bibliography; these articles have been added to the bibliography and to the Science Primary Literature Database. Featured articles: *Chalhoub, R. M., & Kalivas, P. W. (2020). Non‑Opioid treatments for opioid use disorder: Rationales and data to date. Drugs, 80(15), 1509-1524. “Opioid use disorder (OUD) represents a major public health problem that affects millions of people in the…

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