p53 and cancer
p53 is a tumor suppressor protein that is the most commonly mutated gene in tumor/cancer cells. p53 is the most important and most widely studied of the tumor suppressor genes. Mutations in p53 are found in approximately 50% of all human cancers. The most studied tumor suppressor function of p53 is tied to apoptosis (programmed cell death). Cancer therapies that involve mutated tumor suppressor genes…
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