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   Grimm, J.B.; Heckman, L.M.; Lavis, L.D.
   Chemical fluorophores find wide use in biology to detect and visualize different phenomena. A key advantage of small-molecule dyes is the ability to construct compounds where fluorescence is activated by chemical or biochemical processes. Fluorogenic molecules, in which fluorescence is activated by enzymatic activity, light, or environmental changes, enable advanced bioassays and sophisticated imaging experiments. Here, we detail the collection of fluorophores and highlight both general strategies and unique approaches that are employed to control fluorescence using chemistry.

Subject headings: Boron Compounds/chemistry; Calcium/chemistry; Coumarins/chemistry; Fluorescence Resonance Energy Transfer/instrumentation; Fluorescent Dyes/*analysis/chemistry; Hydrogen-Ion Concentration; Hydrolysis; Ions; Light; Photochemistry/methods; Rhodamines/chemistry

Keywords: The chemistry of small-molecule fluorogenic probes
   The chemistry of small-molecule fluorogenic probes
   Progress in Molecular Biology and Translational Science
   Journal Article

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