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Author (up) A/Rahman, S.H.; Mohamedani, A.A.; Mirgani, E.M.; Ibrahim, A.M. file  url
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  Title Gender aspects and women's participation in the control and management of malaria in central Sudan Type Journal Article
  Year 1996 Publication Social Science & Medicine (1982) Abbreviated Journal Soc Sci Med  
  Volume 42 Issue 10 Pages 1433-1446  
  Keywords Adolescent; Adult; Animals; Consumer Participation--methods, psychology, statistics & numerical data; Cost of Illness; Developing Countries--economics, statistics & numerical data; Diarrhea--epidemiology, prevention & control; Female; Health Education--manpower, methods; Humans; Insecticides--adverse effects; Malaria, Falciparum--economics, epidemiology, prevention & control; Male; Medicine, Traditional; Middle Aged; Mosquito Control--methods; Prevalence; Program Evaluation; Sanitation; Schistosomiasis--epidemiology, prevention & control; Sudan--epidemiology; Superstitions; Treatment Outcome; Women; Women's Health  
  Abstract This work was designed to study the contribution of women in central Sudan in the control and management of malaria with particular emphasis on gender-related aspects that define women's role and participation. The Blue Nile Health Project (BNHP 1980-1990) was launched in 1980 mainly for control of water associated diseases in central Sudan. The BNHP model was chosen to conduct this work. The study showed that women were actively involved in the implementation of the BNHP strategies as health instructors (murshidat) who constituted 75% of the staff of BNHP unit of health education, as members of village health committees (VHC) where they constituted 40% of the VHC members and also as recipients of the project services. All murshidat were interviewed whereas multistage random sampling for VHC members and recipient women in 40 villages was used to select a sample which was interviewed. The results showed that the murshidat and VHC women members played a major role in the motivation, organization and health education of local communities prior to campaigns of environmental sanitation and vector control. Household commitments and difficulties in communication with the public were the main gender-related factors that contributed negatively to women's activities. Cases of malaria have more considerable socio-economic impact than other common diseases, especially with regard to women's household commitments and work. Recipient women were more concerned with aspects of self protection, management of family cases of malaria and health education programmes. They were less involved in drying mosquito breeding sites and spraying activities of insecticides which had been reluctantly accepted because of allergy and bad odour. Although the majority of women considered antimalarials to be less harmful than effects of malaria itself on pregnancy, they did not realize the role of malaria chemoprophylaxis during pregnancy. This needs more health education. The study showed that the BNHP programme was very successful in recruiting women in control and management programmes. Therefore, health planners are urged to persuade the subordinated communities of women in many African countries like Sudan to play a more active role in the health programmes and welfare of their communities.  
  Call Number Serial 169  
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Author (up) Akhurst, R.J.; Hata, A. file  url
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  Title Targeting the TGFbeta signalling pathway in disease Type Journal Article
  Year 2012 Publication Nature Reviews. Drug Discovery Abbreviated Journal Nat Rev Drug Discov  
  Volume 11 Issue 10 Pages 790-811  
  Keywords Animals; Drug Delivery Systems/*methods; Humans; Protein Binding/physiology; Receptors, Transforming Growth Factor beta/antagonists & inhibitors/metabolism; Signal Transduction/drug effects/*physiology; Transforming Growth Factor beta/*antagonists & inhibitors/*physiology  
  Abstract Many drugs that target transforming growth factor-beta (TGFbeta) signalling have been developed, some of which have reached Phase III clinical trials for a number of disease applications. Preclinical and clinical studies indicate the utility of these agents in fibrosis and oncology, particularly in augmentation of existing cancer therapies, such as radiation and chemotherapy, as well as in tumour vaccines. There are also reports of specialized applications, such as the reduction of vascular symptoms of Marfan syndrome. Here, we consider why the TGFbeta signalling pathway is a drug target, the potential clinical applications of TGFbeta inhibition, the issues arising with anti-TGFbeta therapy and how these might be tackled using personalized approaches to dosing, monitoring of biomarkers as well as brief and/or localized drug-dosing regimens.  
  Call Number Serial 1548  
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Author (up) Akiskal, H.S. file  url
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  Title The prevalent clinical spectrum of bipolar disorders: beyond DSM-IV Type Journal Article
  Year 1996 Publication Journal of Clinical Psychopharmacology Abbreviated Journal J Clin Psychopharmacol  
  Volume 16 Issue 2 Suppl 1 Pages 4s-14s  
  Keywords Bipolar Disorder/classification/*diagnosis/psychology; Cyclothymic Disorder/classification/diagnosis/psychology; Depressive Disorder/classification/diagnosis/psychology; Diagnosis, Differential; Humans; *Psychiatric Status Rating Scales; Psychotic Disorders/classification/diagnosis/psychology  
  Abstract Based on the author's work and that of collaborators, as well as other contemporaneous research, this article reaffirms the existence of a broad bipolar spectrum between the extremes of psychotic manic-depressive illness and strictly defined unipolar depression. The alternation of mania and melancholia beginning in the juvenile years is one of the most classic descriptions in clinical medicine that has come to us from Greco-Roman times. French alienists in the middle of the nineteenth century and Kraepelin at the turn of that century formalized it into manic-depressive psychosis. In the pre-DSM-III era during the 1960s and 1970s, North American psychiatrists rarely diagnosed the psychotic forms of the disease; now, there is greater recognition that most excited psychoses with a biphasic course, including many with schizo-affective features, belong to the bipolar spectrum. Current data also support Kraepelin's delineation of mixed states, which frequently take on psychotic proportions. However, full syndromal intertwining of depressive and manic states into dysphoric or mixed mania--as emphasized in DSM-IV--is relatively uncommon; depressive symptoms in the midst of mania are more representative of mixed states. DSM-IV also does not formally recognize hypomanic symptomatology that intrudes into major depressive episodes and gives rise to agitated depressive and/or anxious, dysphoric, restless depressions with flight of ideas. Many of these mixed depressive states arise within the setting of an attenuated bipolar spectrum characterized by major depressive episodes and soft signs of bipolarity. DSM-IV conventions are most explicit for the bipolar II subtype with major depressive and clear-cut spontaneous hypomanic episodes; temperamental cyclothymia and hyperthymia receive insufficient recognition as potential factors that could lead to switching from depression to bipolar I disorder and, in vulnerable subjects, to predominantly depressive cycling. In the main, rapid-cycling and mixed states are distinct. Nonetheless, there exist ultrarapid-cycling forms where morose, labile moods with irritable, mixed features constitute patients' habitual self and, for that reason, are often mistaken for “borderline” personality disorder. Clearly, more formal research needs to be conducted in this temperamental interface between more classic bipolar and unipolar disorders. The clinical stakes, however, are such that a narrow concept of bipolar disorder would deprive many patients with lifelong temperamental dysregulation and depressive episodes of the benefits of mood-regulating agents.  
  Call Number Serial 1728  
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Author (up) Alapin, I.; Fichten, C.S.; Libman, E.; Creti, L.; Bailes, S.; Wright, J. file  url
openurl 
  Title How is good and poor sleep in older adults and college students related to daytime sleepiness, fatigue, and ability to concentrate? Type Journal Article
  Year 2000 Publication Journal of Psychosomatic Research Abbreviated Journal J Psychosom Res  
  Volume 49 Issue 5 Pages 381-390  
  Keywords Adaptation, Psychological; Adult; Aged; Attention; Circadian Rhythm--physiology; Cognition Disorders--diagnosis, etiology; Disorders of Excessive Somnolence--diagnosis, etiology; Fatigue--diagnosis, etiology; Female; Humans; Male; Middle Aged; Severity of Illness Index; Sleep--physiology; Sleep Initiation and Maintenance Disorders--complications, diagnosis; Students; Universities; Wakefulness--physiology  
  Abstract We compared good sleepers with minimally and highly distressed poor sleepers on three measures of daytime functioning: self-reported fatigue, sleepiness, and cognitive inefficiency. In two samples (194 older adults, 136 college students), we tested the hypotheses that (1) poor sleepers experience more problems with daytime functioning than good sleepers, (2) highly distressed poor sleepers report greater impairment in functioning during the day than either good sleepers or minimally distressed poor sleepers, (3) daytime symptoms are more closely related to psychological adjustment and to psychologically laden sleep variables than to quantitative sleep parameters, and (4) daytime symptoms are more closely related to longer nocturnal wake times than to shorter sleep times. Results in both samples indicated that poor sleepers reported more daytime difficulties than good sleepers. While low- and high-distress poor sleepers did not differ on sleep parameters, highly distressed poor sleepers reported consistently more difficulty in functioning during the day and experienced greater tension and depression than minimally distressed poor sleepers. Severity of all three daytime problems was generally significantly and positively related to poor psychological adjustment, psychologically laden sleep variables, and, with the exception of sleepiness, to quantitative sleep parameters. Results are used to discuss discrepancies between experiential and quantitative measures of daytime functioning.  
  Call Number Serial 216  
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Author (up) Albuquerque, E.X.; Pereira, E.F.R.; Alkondon, M.; Rogers, S.W. file  url
openurl 
  Title Mammalian nicotinic acetylcholine receptors: from structure to function Type Journal Article
  Year 2009 Publication Physiological Reviews Abbreviated Journal Physiol Rev  
  Volume 89 Issue 1 Pages 73-120  
  Keywords Alzheimer Disease/physiopathology; Animals; Brain/physiology; Disease Models, Animal; Gene Expression Regulation/physiology; Humans; Parkinson Disease/physiopathology; Receptors, Nicotinic/*chemistry/*physiology  
  Abstract The classical studies of nicotine by Langley at the turn of the 20th century introduced the concept of a “receptive substance,” from which the idea of a “receptor” came to light. Subsequent studies aided by the Torpedo electric organ, a rich source of muscle-type nicotinic receptors (nAChRs), and the discovery of alpha-bungarotoxin, a snake toxin that binds pseudo-irreversibly to the muscle nAChR, resulted in the muscle nAChR being the best characterized ligand-gated ion channel hitherto. With the advancement of functional and genetic studies in the late 1980s, the existence of nAChRs in the mammalian brain was confirmed and the realization that the numerous nAChR subtypes contribute to the psychoactive properties of nicotine and other drugs of abuse and to the neuropathology of various diseases, including Alzheimer's, Parkinson's, and schizophrenia, has since emerged. This review provides a comprehensive overview of these findings and the more recent revelations of the impact that the rich diversity in function and expression of this receptor family has on neuronal and nonneuronal cells throughout the body. Despite these numerous developments, our understanding of the contributions of specific neuronal nAChR subtypes to the many facets of physiology throughout the body remains in its infancy.  
  Call Number Serial 1876  
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Author (up) Alcock, J.; Maley, C.C.; Aktipis, C.A. file  url
openurl 
  Title Is eating behavior manipulated by the gastrointestinal microbiota? Evolutionary pressures and potential mechanisms Type Journal Article
  Year 2014 Publication BioEssays : News and Reviews in Molecular, Cellular and Developmental Biology Abbreviated Journal Bioessays  
  Volume 36 Issue 10 Pages 940-949  
  Keywords Animals; *Biological Evolution; *Feeding Behavior; Gastrointestinal Tract/*microbiology; Humans; *Microbiota; Models, Biological; Obesity/etiology; Cravings; Evolutionary conflict; Host manipulation; Microbiome; Obesity  
  Abstract Microbes in the gastrointestinal tract are under selective pressure to manipulate host eating behavior to increase their fitness, sometimes at the expense of host fitness. Microbes may do this through two potential strategies: (i) generating cravings for foods that they specialize on or foods that suppress their competitors, or (ii) inducing dysphoria until we eat foods that enhance their fitness. We review several potential mechanisms for microbial control over eating behavior including microbial influence on reward and satiety pathways, production of toxins that alter mood, changes to receptors including taste receptors, and hijacking of the vagus nerve, the neural axis between the gut and the brain. We also review the evidence for alternative explanations for cravings and unhealthy eating behavior. Because microbiota are easily manipulatable by prebiotics, probiotics, antibiotics, fecal transplants, and dietary changes, altering our microbiota offers a tractable approach to otherwise intractable problems of obesity and unhealthy eating.  
  Call Number Serial 2002  
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Author (up) Allen, S.L.; Lundberg, A.S. file  url
openurl 
  Title Amonafide: a potential role in treating acute myeloid leukemia Type Journal Article
  Year 2011 Publication Expert Opinion on Investigational Drugs Abbreviated Journal Expert Opin Investig Drugs  
  Volume 20 Issue 7 Pages 995-1003  
  Keywords Animals; Antineoplastic Agents--pharmacokinetics, therapeutic use; Clinical Trials as Topic--methods; DNA Topoisomerases, Type II--metabolism; Drug Resistance, Neoplasm; Enzyme Inhibitors--pharmacokinetics, therapeutic use; Humans; Leukemia, Myeloid, Acute--drug therapy, enzymology, mortality; Naphthalimides--pharmacokinetics, therapeutic use; Survival Rate--trends; Treatment Outcome  
  Abstract INTRODUCTION: Amonafide is a novel topoisomerase II (Topo II) inhibitor and DNA intercalator that induces apoptotic signaling by blocking the binding of Topo II to DNA. Amonafide retains cytotoxic activity even in the presence of P-glycoprotein (Pgp)-mediated multi-drug resistance (MDR), a major contributor to clinical treatment failure. AREAS COVERED: In vitro, Pgp-mediated transport (efflux) of amonafide from myeloblasts obtained from patients with secondary acute myeloid leukemia (sAML) was significantly less than efflux of daunorubicin. Amonafide has shown efficacy in patients with sAML, as well as in patients with poor prognostic characteristics such as older age and unfavorable cytogenetics, all associated with MDR. Improved antileukemic activity is observed when amonafide is given together with cytarabine, rather than as monotherapy, with a complete remission rate of approximately 40% in a recent Phase II trial in sAML. The efficacy of amonafide was maintained among poor-risk subsets of patients, including older patients and patients who had previous myelodysplastic syndrome or previous leukemogenic therapy. The safety profile was acceptable and manageable. EXPERT OPINION: Amonafide plus cytarabine may have clinical utility in patients with sAML and in other poor-risk subgroups of acute myeloid leukemia (AML). Ongoing trials will help define the role for amonafide in the treatment of poor-risk AML.  
  Call Number Serial 199  
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Author (up) Altman, S.E.; Shankman, S.A. file  url
openurl 
  Title What is the association between obsessive-compulsive disorder and eating disorders? Type Journal Article
  Year 2009 Publication Clinical Psychology Review Abbreviated Journal Clin Psychol Rev  
  Volume 29 Issue 7 Pages 638-646  
  Keywords Anorexia Nervosa/diagnosis/epidemiology/genetics/psychology; Bulimia Nervosa/diagnosis/epidemiology/genetics/psychology; Causality; Comorbidity; Cross-Sectional Studies; Diseases in Twins/genetics/psychology; Feeding and Eating Disorders/diagnosis/epidemiology/genetics/*psychology; Genotype; Humans; Longitudinal Studies; Obsessive-Compulsive Disorder/diagnosis/epidemiology/genetics/*psychology; Personality Disorders/diagnosis/epidemiology/genetics/psychology  
  Abstract Because eating disorders (EDs) and obsessive compulsive disorder (OCD) co-occur at high rates and can have functionally similar clinical presentations, it has been suggested that both constructs might be part of a common spectrum of disorders. Identifying the relationship between EDs and OCD may lead to the discovery of important shared core disease processes and/or mechanisms for maintenance. The objective of this paper is to understand the relationship between EDs and OCD by systematically reviewing epidemiological, longitudinal and family studies guided by five models of comorbidity posited by Klein and Riso (1993) and others. Though this literature is relatively small, the preponderance of evidence from these studies largely suggests that OCD/ED co-occur because of a shared etiological relationship. Limitations to extant literature, and suggestions for future research are discussed.  
  Call Number Serial 1824  
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Author (up) Amaku, M.; Coutinho, F.A.B.; Massad, E. file  url
openurl 
  Title Why dengue and yellow fever coexist in some areas of the world and not in others? Type Journal Article
  Year 2011 Publication Bio Systems Abbreviated Journal Biosystems  
  Volume 106 Issue 2-3 Pages 111-120  
  Keywords Adaptive Immunity/*immunology; Aedes/*virology; Africa/epidemiology; Animals; Asia/epidemiology; Computer Simulation; *Demography; Dengue/*epidemiology/immunology/transmission; Humans; Insect Vectors/*virology; *Models, Biological; South America/epidemiology; Species Specificity; Yellow Fever/*epidemiology/immunology/transmission  
  Abstract Urban yellow fever and dengue coexist in Africa but not in Asia and South America. In this paper, we examine four hypotheses (and various combinations thereof) to explain the absence of yellow fever in urban areas of Asia and South America. In addition, we examine an additional hypothesis that offers an explanation of the coexistence of the infections in Africa while at the same time explaining their lack of coexistence in Asia. The hypotheses we tested to explain the nonexistence of yellow fever in Asia are the following: (1) the Asian Aedes aegypti is relatively incompetent to transmit yellow fever; (2) there would exist a competition between dengue and yellow fever viruses within the mosquitoes, as suggested by in vitro studies in which the dengue virus always wins; (3) when an A. aegypti mosquito that is infected by or latent for yellow fever acquires dengue, it becomes latent for dengue due to internal competition within the mosquito between the two viruses; (4) there is an important cross-immunity between yellow fever and other flaviviruses, dengue in particular, such that a person recovered from a bout of dengue exhibits a diminished susceptibility to yellow fever. This latter hypothesis is referred to below as the “Asian hypothesis.” Finally, we hypothesize that: (5) the coexistence of the infections in Africa is due to the low prevalence of the mosquito Aedes albopictus in Africa, as it competes with A. aegypti. We will refer to this latter hypothesis as the “African hypothesis.” We construct a model of transmission that allows all of the above hypotheses to be tested. We conclude that the Asian and the African hypotheses can explain the observed phenomena, whereas other hypotheses fail to do so.  
  Call Number Serial 1532  
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Author (up) Amato, P.R. file  url
openurl 
  Title Children of divorce in the 1990s: an update of the Amato and Keith (1991) meta-analysis Type Journal Article
  Year 2001 Publication Journal of Family Psychology : JFP : Journal of the Division of Family Psychology of the American Psychological Association (Division 43) Abbreviated Journal J Fam Psychol  
  Volume 15 Issue 3 Pages 355-370  
  Keywords Adolescent; Adult; Age Factors; Child; Child Psychology; Child, Preschool; Divorce--psychology; Educational Status; Female; Humans; Male; Marriage--psychology; Mental Health; Research Design; Self Concept; Sex Factors; Social Adjustment; United States--epidemiology  
  Abstract The present study updates the P. R. Amato and B. Keith (1991) meta-analysis of children and divorce with a new analysis of 67 studies published in the 1990s. Compared with children with continuously married parents, children with divorced parents continued to score significantly lower on measures of academic achievement, conduct, psychological adjustment, self-concept, and social relations. After controlling for study characteristics, curvilinear trends with respect to decade of publication were present for academic achievement, psychological well-being, self-concept, and social relations. For these outcomes, the gap between children with divorced and married parents decreased during the 1980s and increased again during the 1990s.  
  Call Number Serial 276  
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