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Author (up) Adachi, R.; Wakabayashi, T.; Oda, N.; Shingai, R. file  url
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  Title Modulation of Caenorhabditis elegans chemotaxis by cultivation and assay temperatures Type Journal Article
  Year 2008 Publication Neuroscience Research Abbreviated Journal Neurosci Res  
  Volume 60 Issue 3 Pages 300-306  
  Keywords Ammonium Chloride; Animals; Behavior, Animal/*physiology; Caenorhabditis elegans/*physiology; Chemoreceptor Cells/physiology; Chemotaxis/*physiology; Neurons, Afferent/*physiology; Sodium Acetate; Stimulation, Chemical; *Temperature  
  Abstract The chemotaxis behaviors of the nematode Caenorhabditis elegans cultivated at various temperatures (15 degrees C, 20 degrees C and 25 degrees C) were examined at various temperatures (10 degrees C, 15 degrees C, 20 degrees C and 25 degrees C) to determine the multi-sensory integration of physical (thermal) and chemical sensory information within its nervous system. Chemotaxis behavior toward sodium acetate and ammonium chloride were differently affected by both assay and cultivation temperatures, suggesting that the temperature effect on chemotaxis is not general, but rather distinctive for each chemosensory pathway. Since thermosensory cues are likely encountered constantly in C. elegans, we supposed that the chemotaxis behaviors of worms are achieved by the integration of chemo- and thermosensory information. To verify the possible contribution of thermosensory function in chemotaxis, we examined the chemotaxis behaviors of ttx-1(p767) mutant worms with defective AFD thermosensory neurons. The chemotaxis behaviors toward sodium acetate or ammonium chloride of mutant worms cultivated at 20 degrees C and 25 degrees C were reduced relative to those of wild-type worms. These results indicate the important role of multi-sensory integration of chemosensory and thermosensory information in chemotaxis behavior of the C. elegans.  
  Call Number Serial 1025  
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Author (up) Marriott, A.S. file  url
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  Title The effects of amphetamine, caffeine and methylphenidate on the locomotor activity of rats in an unfamiliar environment Type Journal Article
  Year 1968 Publication International Journal of Neuropharmacology Abbreviated Journal Int J Neuropharmacol  
  Volume 7 Issue 6 Pages 487-491  
  Keywords Amphetamine/administration & dosage/*pharmacology; Animals; Caffeine/administration & dosage/*pharmacology; Learning/*drug effects; Male; Methylphenidate/administration & dosage/*pharmacology; Motor Activity/*drug effects; Rats; Stimulation, Chemical  
  Abstract The effects of amphetamine, methylphenidate and caffeine were investigated on the locomotor activity of rats in a novel Y-maze situation. Parallel studies were made using locomotor wheels. Neither amphetamine nor caffeine increased Y-maze activity at doses which increased locomotor wheel activity. In contrast methylphenidate greatly increased activity in the Y-maze indicating a qualitative difference in the effects of this drug.  
  Call Number Serial 1577  
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