Amyloid-Beta pores

A new way of looking at Alzheimer’s Disease?

A different perspective on the factors that cause Alzheimer’s disease? Will it help bring about successful treatments? Featured article: *Pannuzzo, M. (2021, May 29). Beta-amyloid pore linked to controlled calcium influx into the cell: A new paradigm for Alzheimer’s disease. Alzheimer’s & Dementia : The Journal of the Alzheimer’s Association. [PDF] “Despite tremendous worldwide efforts, clinical trials assessing Alzheimer’s disease (AD)-related therapeutics have been relentlessly…

See more
Diels-Alder reaction

The Diels-Alder reaction: a mainstay of organic chemistry

The Diels-Alder reaction is one of the most important in Organic Chemistry and plays a role in the synthesis and manufacture of many products including pharmaceutical ingredients (including vitamins and drugs), agrochemicals (including fungicides), flavors, fragrances, and more. The reaction is also found in nature, in the synthesis of natural products. Background: *Boger, D. & Weinreb, S. (1987). Hetero Diels-Alder Methodology in Organic Synthesis. Organic…

See more

Opioids: addiction and overdose — update

An update to the Opioids, addiction, and overdose bibliography; these articles have been added to the bibliography and to the Science Primary Literature Database. Featured articles: *Chalhoub, R. M., & Kalivas, P. W. (2020). Non‑Opioid treatments for opioid use disorder: Rationales and data to date. Drugs, 80(15), 1509-1524. “Opioid use disorder (OUD) represents a major public health problem that affects millions of people in the…

See more

T cells and autoimmune disease

An update to the Autoimmune diseases–prevention and control bibliography; this article has been added to the bibliography and to the Science Primary Literature Database. Featured article: *Lee, D. J. (2020). The relationship between TIGIT+ regulatory T cells and autoimmune disease. International Immunopharmacology, 83, 1. [Cited by] “The role of regulatory T cells (Treg cell) in controlling autoimmune disease is an area of intense study. As…

See more

Parent influence on child obesity

How do parents influence the development of obesity in their children? Conversely, how can parents prevent child obesity? An update to the Childhood obesity and parents’ influence bibliography. Featured articles (these articles have been added to the bibliography): *Benton, D. (2004). Role of parents in the determination of the food preferences of children and the development of obesity. International Journal of Obesity and Related Disorders,…

See more

High-sugar diets: Discovering human impacts through animal models

High-sugar diets can have many negative effects. One way to pinpoint the physical changes they can cause in humans is to test their effects on animal models that share similarities with humans. Featured articles (these articles have been added to the Science Primary Literature database): *Alcántar-Fernández, J., González-Maciel, A., Reynoso-Robles, R., Martha Elva Pérez Andrade, de J Hernández-Vázquez, A., Velázquez-Arellano, A., & Miranda-Ríos, J. (2019)….

See more